Effect of different water-soluble forms of fullerene C^sub 60^ on the metabolic activity and ultrastructure of cells in culture
In view of contradictory data on the toxicity of fullerenes for living organisms we studied the effect of water-soluble complexes of C^sub 60^ with N-polyvinylpyrrolidone (C^sub 60^/PVP) and γ-cyclodextrin (C^sub 60^/γ-CD) on MA-104 cells in culture. Both complexes proved to be nontoxic for cultured...
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| Veröffentlicht in: | Biophysics (Oxford) 2012-05, Vol.57 (3), p.343 |
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| container_title | Biophysics (Oxford) |
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| creator | Eropkina, E M Ilyinskaya, E V Litasova, E V Eropkin, M Yu Piotrovsky, L B Dumpis, M A Kiselev, O I |
| description | In view of contradictory data on the toxicity of fullerenes for living organisms we studied the effect of water-soluble complexes of C^sub 60^ with N-polyvinylpyrrolidone (C^sub 60^/PVP) and γ-cyclodextrin (C^sub 60^/γ-CD) on MA-104 cells in culture. Both complexes proved to be nontoxic for cultured cells in the dark in a wide range of concentrations. Both complexes provoke changes of cell ultrastructure that reflect enhancement of metabolic activity. At the same time only the exposition with C^sub 60^/PVP leads to substantial growth of the number and size of mitochondria. However, the effect of two studied water-soluble forms of C^sub 60^ under intense UV irradiation of cells proved to be opposite: C^sub 60^/PVP had a cytoprotective action while C^sub 60^/γ-CD caused a significant growth of phototoxicity. Possible reasons of the differences in the action of different forms of C^sub 60^ on living organisms are discussed.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1134/S0006350912030074 |
| format | Article |
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Both complexes proved to be nontoxic for cultured cells in the dark in a wide range of concentrations. Both complexes provoke changes of cell ultrastructure that reflect enhancement of metabolic activity. At the same time only the exposition with C^sub 60^/PVP leads to substantial growth of the number and size of mitochondria. However, the effect of two studied water-soluble forms of C^sub 60^ under intense UV irradiation of cells proved to be opposite: C^sub 60^/PVP had a cytoprotective action while C^sub 60^/γ-CD caused a significant growth of phototoxicity. 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| subjects | Biophysics Cell culture Cellular biology Fullerenes Metabolism Toxicity |
| title | Effect of different water-soluble forms of fullerene C^sub 60^ on the metabolic activity and ultrastructure of cells in culture |
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