Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1–DTX2 chimera

The RUNX1 gene is frequently rearranged in acute leukemia. We cloned a novel RUNX1 chimeric gene generated by t(7;21)(q11.2;q22) in a patient with acute myeloid leukemia. 3′-rapid amplification of cDNA ends analysis showed a tail-to-tail fusion between RUNX1 on 21q22 and DTX2 on 7q11.2, with an inse...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of hematology 2012-08, Vol.96 (2), p.268-273
Hauptverfasser:	Maki, Kazuhiro, Sasaki, Ko, Sugita, Fusako, Nakamura, Yuka, Mitani, Kinuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Aged, 80 and over Biological and medical sciences Case Report Chromosome aberrations Chromosome Banding Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 7 Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Female Gene Expression Gene Order Hematologic and hematopoietic diseases Hematology Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical genetics Medical sciences Medicine Medicine & Public Health Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Translocation, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!