Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy
Aim To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels. Subjects and methods Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls (P = 0.18) were tested for HGF concentratio...
Gespeichert in:
| Veröffentlicht in: | Proteomics insights 2010, Vol.2010 (3), p.71 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 71 |
| container_title | Proteomics insights |
| container_volume | 2010 |
| creator | Russo, A.J. deVito, Robert |
| description | Aim
To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels.
Subjects and methods
Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls (P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry.
Results
HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls (P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy (P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety (P = 0.03), improved significantly after therapy.
Discussion
These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms. |
| doi_str_mv | 10.4137/PRI.S6145 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1035228967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A390189274</galeid><sage_id>10.4137_PRI.S6145</sage_id><sourcerecordid>A390189274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3205-1e42243587e377e9b4ca4b12a2bb90b11db1b218803d5c519e3c0c2f4a6178673</originalsourceid><addsrcrecordid>eNptkctq3DAUhk1poSHJom8gKJRm4YlutuRNIU0zFwhN6aSbbsSxfJxRGFuu5EmYPH2UTijTptJCB53vPxf-LHvH6EQyoU6_fV9MliWTxavsgDGl81Iy_Xovfpsdx3hLn46iSouD7O4L2oAQsSFLDJuOzHGA0dvtiGQW_P24IlOwow_k43w2PSGuJ4u-cXeu2cA6knuXgKVduQc_rAL2DshXHzpYuweMBNoRA_npekugb8jnvCTXKwwwbI-yN23S4_Hze5j9mF5cn8_zy6vZ4vzsMreC0yJnKDmXotAKhVJY1dKCrBkHXtcVrRlralZzpjUVTWELVqGw1PJWQplWLpU4zN7v6g7B_9pgHM2t34Q-tTSMioJzXe1TN7BG4_rWjwFs56I1Z6KiTFdcyURN_kOl22DnrO-xden_L8HJTmCDjzFga4bgOgjb1Ns8GWaSYea3YYn9sGMj3OD-kC_BTztw7WoMI8TnAeBPcQ_O_JO0YKzvDBdai0egFajK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035228967</pqid></control><display><type>article</type><title>Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Russo, A.J. ; deVito, Robert</creator><creatorcontrib>Russo, A.J. ; deVito, Robert</creatorcontrib><description>Aim
To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels.
Subjects and methods
Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls (P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry.
Results
HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls (P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy (P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety (P = 0.03), improved significantly after therapy.
Discussion
These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms.</description><identifier>ISSN: 1178-6418</identifier><identifier>EISSN: 1178-6418</identifier><identifier>DOI: 10.4137/PRI.S6145</identifier><language>eng</language><publisher>London, England: SAGE Publishing</publisher><subject>Care and treatment ; Growth factors ; Health aspects ; Liver cells ; Physiological aspects ; Psychological aspects ; Schizophrenia ; Vitamin B6 ; Zinc in the body</subject><ispartof>Proteomics insights, 2010, Vol.2010 (3), p.71</ispartof><rights>2010 SAGE Publications.</rights><rights>COPYRIGHT 2010 Sage Publications Ltd. (UK)</rights><rights>Copyright Libertas Academica Ltd 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3205-1e42243587e377e9b4ca4b12a2bb90b11db1b218803d5c519e3c0c2f4a6178673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>Russo, A.J.</creatorcontrib><creatorcontrib>deVito, Robert</creatorcontrib><title>Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy</title><title>Proteomics insights</title><description>Aim
To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels.
Subjects and methods
Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls (P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry.
Results
HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls (P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy (P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety (P = 0.03), improved significantly after therapy.
Discussion
These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms.</description><subject>Care and treatment</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Liver cells</subject><subject>Physiological aspects</subject><subject>Psychological aspects</subject><subject>Schizophrenia</subject><subject>Vitamin B6</subject><subject>Zinc in the body</subject><issn>1178-6418</issn><issn>1178-6418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkctq3DAUhk1poSHJom8gKJRm4YlutuRNIU0zFwhN6aSbbsSxfJxRGFuu5EmYPH2UTijTptJCB53vPxf-LHvH6EQyoU6_fV9MliWTxavsgDGl81Iy_Xovfpsdx3hLn46iSouD7O4L2oAQsSFLDJuOzHGA0dvtiGQW_P24IlOwow_k43w2PSGuJ4u-cXeu2cA6knuXgKVduQc_rAL2DshXHzpYuweMBNoRA_npekugb8jnvCTXKwwwbI-yN23S4_Hze5j9mF5cn8_zy6vZ4vzsMreC0yJnKDmXotAKhVJY1dKCrBkHXtcVrRlralZzpjUVTWELVqGw1PJWQplWLpU4zN7v6g7B_9pgHM2t34Q-tTSMioJzXe1TN7BG4_rWjwFs56I1Z6KiTFdcyURN_kOl22DnrO-xden_L8HJTmCDjzFga4bgOgjb1Ns8GWaSYea3YYn9sGMj3OD-kC_BTztw7WoMI8TnAeBPcQ_O_JO0YKzvDBdai0egFajK</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Russo, A.J.</creator><creator>deVito, Robert</creator><general>SAGE Publishing</general><general>SAGE Publications</general><general>Sage Publications Ltd. (UK)</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2010</creationdate><title>Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy</title><author>Russo, A.J. ; deVito, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3205-1e42243587e377e9b4ca4b12a2bb90b11db1b218803d5c519e3c0c2f4a6178673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Care and treatment</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Liver cells</topic><topic>Physiological aspects</topic><topic>Psychological aspects</topic><topic>Schizophrenia</topic><topic>Vitamin B6</topic><topic>Zinc in the body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russo, A.J.</creatorcontrib><creatorcontrib>deVito, Robert</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Australia & New Zealand Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Proteomics insights</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russo, A.J.</au><au>deVito, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy</atitle><jtitle>Proteomics insights</jtitle><date>2010</date><risdate>2010</risdate><volume>2010</volume><issue>3</issue><spage>71</spage><pages>71-</pages><issn>1178-6418</issn><eissn>1178-6418</eissn><abstract>Aim
To assess serum HGF concentration in individuals with schizophrenia and investigate the efficacy of zinc and B-6 therapy on these levels.
Subjects and methods
Serum from 18 individuals diagnosed with schizophrenia and 19 age and gender similar controls (P = 0.18) were tested for HGF concentration using ELISAs, and tested for copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry.
Results
HGF serum levels of individuals with schizophrenia, before zinc and B-6 therapy, were significantly lower than age and gender similar controls (P = 0.016), and significantly lower in schizophrenia patients pre-therapy compared to post therapy (P = 0.028). HGF levels normalized (reached levels similar to controls) post-therapy. Zinc levels in these same individuals also normalized, and perceived symptoms, particularly anxiety (P = 0.03), improved significantly after therapy.
Discussion
These results suggest an association between low HGF levels and schizophrenia and demonstrate that zinc and B-6 therapy may be associated with the normalization of HGF levels and perceived improvement in symptoms.</abstract><cop>London, England</cop><pub>SAGE Publishing</pub><doi>10.4137/PRI.S6145</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1178-6418 |
| ispartof | Proteomics insights, 2010, Vol.2010 (3), p.71 |
| issn | 1178-6418 1178-6418 |
| language | eng |
| recordid | cdi_proquest_journals_1035228967 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Care and treatment Growth factors Health aspects Liver cells Physiological aspects Psychological aspects Schizophrenia Vitamin B6 Zinc in the body |
| title | Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Schizophrenia Normalizes after Zinc and B-6 Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T03%3A36%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20Serum%20Hepatocyte%20Growth%20Factor%20(HGF)%20in%20Individuals%20with%20Schizophrenia%20Normalizes%20after%20Zinc%20and%20B-6%20Therapy&rft.jtitle=Proteomics%20insights&rft.au=Russo,%20A.J.&rft.date=2010&rft.volume=2010&rft.issue=3&rft.spage=71&rft.pages=71-&rft.issn=1178-6418&rft.eissn=1178-6418&rft_id=info:doi/10.4137/PRI.S6145&rft_dat=%3Cgale_proqu%3EA390189274%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1035228967&rft_id=info:pmid/&rft_galeid=A390189274&rft_sage_id=10.4137_PRI.S6145&rfr_iscdi=true |