Association of hormone replacement therapy with bronchial hyper-responsiveness
Postmenopausal hormone replacement therapy (HRT) has been linked to asthma in women, however, with inconsistent conclusions. This study examined the association of HRT with bronchial hyper-responsiveness (BHR). Eighty-five postmenopausal women completed a women-specific questionnaire and underwent m...
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| Veröffentlicht in: | Respiratory medicine 2003-08, Vol.97 (8), p.990-992 |
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| creator | Mueller, Judith E Frye, Christian Brasche, Sabine Heinrich, Joachim |
| description | Postmenopausal hormone replacement therapy (HRT) has been linked to asthma in women, however, with inconsistent conclusions. This study examined the association of HRT with bronchial hyper-responsiveness (BHR). Eighty-five postmenopausal women completed a women-specific questionnaire and underwent methacholine challenge testing according to the protocol of the European community respiratory health survey. Associations of HRT use with BHR (based on a 20% fall in FEV
1), mild BHR (10% fall in FEV
1) or dichotomized dose–response slopes were analyzed by logistic regression, controlling for age, education, smoking and overweight. The 27 HRT users were less likely to show BHR compared to the 58 non-users (11% vs. 41%), multiply adjusted odds ratio (95% confidence interval) 0.12 (0.03, 0.55). Results for dose–response slopes were similar, while mild BHR showed no association with HRT use. These results point to a relaxing effect of estrogens on bronchial smooth muscle. |
| doi_str_mv | 10.1016/S0954-6111(03)00128-8 |
| format | Article |
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1), mild BHR (10% fall in FEV
1) or dichotomized dose–response slopes were analyzed by logistic regression, controlling for age, education, smoking and overweight. The 27 HRT users were less likely to show BHR compared to the 58 non-users (11% vs. 41%), multiply adjusted odds ratio (95% confidence interval) 0.12 (0.03, 0.55). Results for dose–response slopes were similar, while mild BHR showed no association with HRT use. These results point to a relaxing effect of estrogens on bronchial smooth muscle.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/S0954-6111(03)00128-8</identifier><identifier>PMID: 12924529</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Angina pectoris ; Asthma ; Biological and medical sciences ; Bronchial hyper-responsiveness ; Bronchial Hyperreactivity - chemically induced ; Bronchial Hyperreactivity - physiopathology ; Cardiovascular disease ; Chronic obstructive pulmonary disease, asthma ; Confidence intervals ; Estrogen Replacement Therapy - adverse effects ; Female ; Forced Expiratory Volume - drug effects ; Hormone replacement therapy ; Humans ; Logistic Models ; Medical sciences ; Menopause ; Middle Aged ; Pneumology ; Postmenopausal hormone replacement therapy ; Regression Analysis ; Smooth muscle ; Studies ; Womens health</subject><ispartof>Respiratory medicine, 2003-08, Vol.97 (8), p.990-992</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d8d1520dca479047635406caa4fe7c53caac292775972b67ea1b55defe8acb1b3</citedby><cites>FETCH-LOGICAL-c466t-d8d1520dca479047635406caa4fe7c53caac292775972b67ea1b55defe8acb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0954-6111(03)00128-8$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15265770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12924529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mueller, Judith E</creatorcontrib><creatorcontrib>Frye, Christian</creatorcontrib><creatorcontrib>Brasche, Sabine</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><title>Association of hormone replacement therapy with bronchial hyper-responsiveness</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Postmenopausal hormone replacement therapy (HRT) has been linked to asthma in women, however, with inconsistent conclusions. This study examined the association of HRT with bronchial hyper-responsiveness (BHR). Eighty-five postmenopausal women completed a women-specific questionnaire and underwent methacholine challenge testing according to the protocol of the European community respiratory health survey. Associations of HRT use with BHR (based on a 20% fall in FEV
1), mild BHR (10% fall in FEV
1) or dichotomized dose–response slopes were analyzed by logistic regression, controlling for age, education, smoking and overweight. The 27 HRT users were less likely to show BHR compared to the 58 non-users (11% vs. 41%), multiply adjusted odds ratio (95% confidence interval) 0.12 (0.03, 0.55). Results for dose–response slopes were similar, while mild BHR showed no association with HRT use. These results point to a relaxing effect of estrogens on bronchial smooth muscle.</description><subject>Angina pectoris</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Bronchial hyper-responsiveness</subject><subject>Bronchial Hyperreactivity - chemically induced</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Confidence intervals</subject><subject>Estrogen Replacement Therapy - adverse effects</subject><subject>Female</subject><subject>Forced Expiratory Volume - drug effects</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Postmenopausal hormone replacement therapy</subject><subject>Regression Analysis</subject><subject>Smooth muscle</subject><subject>Studies</subject><subject>Womens health</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKUggh6qkzYf7UlE_ALRg3oOaTqlkd2kJt2V_fdGd9Gjp5nD874zPIQcUjinQMXFC9Sc5YJSegrlGQAtqrzaIBPKyyIvQbBNMvlFdshujO8AUDMG22SHFnXBeFFPyNNVjN5YPVrvMt9lvQ8z7zALOEy1wRm6MRt7DHpYZp927LMmeGd6q6dZvxww5AHj4F20C3QY4z7Z6vQ04sF67pG325vX6_v88fnu4frqMTdMiDFvq5byAlqjmayBSVFyBsJozTqUhpdpM-lFKXkti0ZI1LThvMUOK20a2pR75HjVOwT_Mcc4qnc_Dy6dVBRKDqyiok4UX1Em-BgDdmoIdqbDMkHq26L6sai-FSko1Y9FVaXc0bp93syw_UuttSXgZA3oaPS0C9oZG_84XgguJSTucsVhcrGwGFQ0Fp3B1gY0o2q9_eeVL71aj1o</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Mueller, Judith E</creator><creator>Frye, Christian</creator><creator>Brasche, Sabine</creator><creator>Heinrich, Joachim</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>20030801</creationdate><title>Association of hormone replacement therapy with bronchial hyper-responsiveness</title><author>Mueller, Judith E ; Frye, Christian ; Brasche, Sabine ; Heinrich, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d8d1520dca479047635406caa4fe7c53caac292775972b67ea1b55defe8acb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Angina pectoris</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Bronchial hyper-responsiveness</topic><topic>Bronchial Hyperreactivity - chemically induced</topic><topic>Bronchial Hyperreactivity - physiopathology</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Confidence intervals</topic><topic>Estrogen Replacement Therapy - adverse effects</topic><topic>Female</topic><topic>Forced Expiratory Volume - drug effects</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Postmenopausal hormone replacement therapy</topic><topic>Regression Analysis</topic><topic>Smooth muscle</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller, Judith E</creatorcontrib><creatorcontrib>Frye, Christian</creatorcontrib><creatorcontrib>Brasche, Sabine</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller, Judith E</au><au>Frye, Christian</au><au>Brasche, Sabine</au><au>Heinrich, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of hormone replacement therapy with bronchial hyper-responsiveness</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>97</volume><issue>8</issue><spage>990</spage><epage>992</epage><pages>990-992</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Postmenopausal hormone replacement therapy (HRT) has been linked to asthma in women, however, with inconsistent conclusions. This study examined the association of HRT with bronchial hyper-responsiveness (BHR). Eighty-five postmenopausal women completed a women-specific questionnaire and underwent methacholine challenge testing according to the protocol of the European community respiratory health survey. Associations of HRT use with BHR (based on a 20% fall in FEV
1), mild BHR (10% fall in FEV
1) or dichotomized dose–response slopes were analyzed by logistic regression, controlling for age, education, smoking and overweight. The 27 HRT users were less likely to show BHR compared to the 58 non-users (11% vs. 41%), multiply adjusted odds ratio (95% confidence interval) 0.12 (0.03, 0.55). Results for dose–response slopes were similar, while mild BHR showed no association with HRT use. These results point to a relaxing effect of estrogens on bronchial smooth muscle.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12924529</pmid><doi>10.1016/S0954-6111(03)00128-8</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angina pectoris Asthma Biological and medical sciences Bronchial hyper-responsiveness Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - physiopathology Cardiovascular disease Chronic obstructive pulmonary disease, asthma Confidence intervals Estrogen Replacement Therapy - adverse effects Female Forced Expiratory Volume - drug effects Hormone replacement therapy Humans Logistic Models Medical sciences Menopause Middle Aged Pneumology Postmenopausal hormone replacement therapy Regression Analysis Smooth muscle Studies Womens health |
| title | Association of hormone replacement therapy with bronchial hyper-responsiveness |
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