The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma
Background: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attentio...
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| Veröffentlicht in: | Respiratory medicine 2003-10, Vol.97 (10), p.1120-1125 |
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| creator | Weiner, Paltiel Beckerman, Marinella Berar-Yanay, Noa Magadle, Rasmi |
| description | Background: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators.
Study objective: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance.
Methods: The POD was measured in 26 mild–moderate asthmatic patients following bronchodilation, using
β
2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude.
Results: The increase in forced expiratory volume in 1
s (FEV
1), 30
min after the inhalation of
β
2-agonist (mean±SEM 22.3±0.8%), was associated with a statistically significant decrease (
P |
| doi_str_mv | 10.1016/S0954-6111(03)00161-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1035047855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0954611103001616</els_id><sourcerecordid>2745012291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-48a14a34df6e7bdafb9208ab4bbdd081240a698b0127c4ca3ea6a72fc9e9d9e83</originalsourceid><addsrcrecordid>eNqFkMFq3DAQhkVoaTZpHyHBUALJwenIlmX7VEpI08JCDt2exVgaswq7kiNpU_bto-xukmNPI36--Ud8jJ1xuObA5bc_0DeilJzzS6ivIEe8lEdsxpu6KmuQ4gObvSHH7CTGBwDohYBP7JiLRuaWfsbUYknFREHTlKx3hR8Ls42TIyxwTBSKIXinl157F1OwegehM6-5sSvcZdYVU36RS7H4Z9OywJiWa_zMPo64ivTlME_Z35-3i5tf5fz-7vfNj3mphZSpFB1ygbUwo6R2MDgOfQUdDmIYjIGOVwJQ9t0AvGq10FgTSmyrUffUm566-pR93fdOwT9uKCb14DfB5ZOKQ92AaLumyVSzp3TwMQYa1RTsGsM2Q-pFq9ppVS_OFNRqp1XJvHd-aN8MazLvWwePGbg4ABg1rsaATtv4zjWct5VsM_d9z1F28WQpqKizM03GBtJJGW__85VnRryVsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035047855</pqid></control><display><type>article</type><title>The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Weiner, Paltiel ; Beckerman, Marinella ; Berar-Yanay, Noa ; Magadle, Rasmi</creator><creatorcontrib>Weiner, Paltiel ; Beckerman, Marinella ; Berar-Yanay, Noa ; Magadle, Rasmi</creatorcontrib><description>Background: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators.
Study objective: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance.
Methods: The POD was measured in 26 mild–moderate asthmatic patients following bronchodilation, using
β
2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude.
Results: The increase in forced expiratory volume in 1
s (FEV
1), 30
min after the inhalation of
β
2-agonist (mean±SEM 22.3±0.8%), was associated with a statistically significant decrease (
P<0.005) in the POD. The mean decrease in FEV
1 following methacoline challenge, was 23±0.7% and was followed by a statistically significant increase (
P<0.005) in the POD. The magnitude of the decrease in the POD following albuterol was almost identical to the magnitude of the increase in the POD following methacholine.
Conclusions: In stable mild–moderate asthmatic patients, the changes in the magnitude of dyspnea, perceived by a subject, is independent on the direction of the change in the FEV
1.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/S0954-6111(03)00161-6</identifier><identifier>PMID: 14561019</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adrenergic beta-2 Receptor Antagonists ; Adult ; Airway management ; Airway systems ; Asthma ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Provocation Tests ; Bronchoconstriction - drug effects ; Bronchoconstriction - physiology ; Bronchoconstrictor Agents - adverse effects ; Bronchodilator Agents - adverse effects ; Chronic obstructive pulmonary disease, asthma ; Dyspnea - chemically induced ; Dyspnea - psychology ; Female ; Forced Expiratory Volume - drug effects ; Humans ; Influence of bronchoconstriction and bronchodilation ; Male ; Medical sciences ; Methacholine Chloride ; Mortality ; Perception ; Perception of dyspnea ; Pneumology</subject><ispartof>Respiratory medicine, 2003-10, Vol.97 (10), p.1120-1125</ispartof><rights>2003 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-48a14a34df6e7bdafb9208ab4bbdd081240a698b0127c4ca3ea6a72fc9e9d9e83</citedby><cites>FETCH-LOGICAL-c466t-48a14a34df6e7bdafb9208ab4bbdd081240a698b0127c4ca3ea6a72fc9e9d9e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611103001616$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15117267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14561019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiner, Paltiel</creatorcontrib><creatorcontrib>Beckerman, Marinella</creatorcontrib><creatorcontrib>Berar-Yanay, Noa</creatorcontrib><creatorcontrib>Magadle, Rasmi</creatorcontrib><title>The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Background: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators.
Study objective: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance.
Methods: The POD was measured in 26 mild–moderate asthmatic patients following bronchodilation, using
β
2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude.
Results: The increase in forced expiratory volume in 1
s (FEV
1), 30
min after the inhalation of
β
2-agonist (mean±SEM 22.3±0.8%), was associated with a statistically significant decrease (
P<0.005) in the POD. The mean decrease in FEV
1 following methacoline challenge, was 23±0.7% and was followed by a statistically significant increase (
P<0.005) in the POD. The magnitude of the decrease in the POD following albuterol was almost identical to the magnitude of the increase in the POD following methacholine.
Conclusions: In stable mild–moderate asthmatic patients, the changes in the magnitude of dyspnea, perceived by a subject, is independent on the direction of the change in the FEV
1.</description><subject>Adrenergic beta-2 Receptor Antagonists</subject><subject>Adult</subject><subject>Airway management</subject><subject>Airway systems</subject><subject>Asthma</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Bronchoconstriction - drug effects</subject><subject>Bronchoconstriction - physiology</subject><subject>Bronchoconstrictor Agents - adverse effects</subject><subject>Bronchodilator Agents - adverse effects</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Dyspnea - chemically induced</subject><subject>Dyspnea - psychology</subject><subject>Female</subject><subject>Forced Expiratory Volume - drug effects</subject><subject>Humans</subject><subject>Influence of bronchoconstriction and bronchodilation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Chloride</subject><subject>Mortality</subject><subject>Perception</subject><subject>Perception of dyspnea</subject><subject>Pneumology</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVoaTZpHyHBUALJwenIlmX7VEpI08JCDt2exVgaswq7kiNpU_bto-xukmNPI36--Ud8jJ1xuObA5bc_0DeilJzzS6ivIEe8lEdsxpu6KmuQ4gObvSHH7CTGBwDohYBP7JiLRuaWfsbUYknFREHTlKx3hR8Ls42TIyxwTBSKIXinl157F1OwegehM6-5sSvcZdYVU36RS7H4Z9OywJiWa_zMPo64ivTlME_Z35-3i5tf5fz-7vfNj3mphZSpFB1ygbUwo6R2MDgOfQUdDmIYjIGOVwJQ9t0AvGq10FgTSmyrUffUm566-pR93fdOwT9uKCb14DfB5ZOKQ92AaLumyVSzp3TwMQYa1RTsGsM2Q-pFq9ppVS_OFNRqp1XJvHd-aN8MazLvWwePGbg4ABg1rsaATtv4zjWct5VsM_d9z1F28WQpqKizM03GBtJJGW__85VnRryVsw</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Weiner, Paltiel</creator><creator>Beckerman, Marinella</creator><creator>Berar-Yanay, Noa</creator><creator>Magadle, Rasmi</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>20031001</creationdate><title>The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma</title><author>Weiner, Paltiel ; Beckerman, Marinella ; Berar-Yanay, Noa ; Magadle, Rasmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-48a14a34df6e7bdafb9208ab4bbdd081240a698b0127c4ca3ea6a72fc9e9d9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenergic beta-2 Receptor Antagonists</topic><topic>Adult</topic><topic>Airway management</topic><topic>Airway systems</topic><topic>Asthma</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Bronchoconstriction - drug effects</topic><topic>Bronchoconstriction - physiology</topic><topic>Bronchoconstrictor Agents - adverse effects</topic><topic>Bronchodilator Agents - adverse effects</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Dyspnea - chemically induced</topic><topic>Dyspnea - psychology</topic><topic>Female</topic><topic>Forced Expiratory Volume - drug effects</topic><topic>Humans</topic><topic>Influence of bronchoconstriction and bronchodilation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Chloride</topic><topic>Mortality</topic><topic>Perception</topic><topic>Perception of dyspnea</topic><topic>Pneumology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiner, Paltiel</creatorcontrib><creatorcontrib>Beckerman, Marinella</creatorcontrib><creatorcontrib>Berar-Yanay, Noa</creatorcontrib><creatorcontrib>Magadle, Rasmi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiner, Paltiel</au><au>Beckerman, Marinella</au><au>Berar-Yanay, Noa</au><au>Magadle, Rasmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>97</volume><issue>10</issue><spage>1120</spage><epage>1125</epage><pages>1120-1125</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Background: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators.
Study objective: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance.
Methods: The POD was measured in 26 mild–moderate asthmatic patients following bronchodilation, using
β
2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude.
Results: The increase in forced expiratory volume in 1
s (FEV
1), 30
min after the inhalation of
β
2-agonist (mean±SEM 22.3±0.8%), was associated with a statistically significant decrease (
P<0.005) in the POD. The mean decrease in FEV
1 following methacoline challenge, was 23±0.7% and was followed by a statistically significant increase (
P<0.005) in the POD. The magnitude of the decrease in the POD following albuterol was almost identical to the magnitude of the increase in the POD following methacholine.
Conclusions: In stable mild–moderate asthmatic patients, the changes in the magnitude of dyspnea, perceived by a subject, is independent on the direction of the change in the FEV
1.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14561019</pmid><doi>10.1016/S0954-6111(03)00161-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Respiratory medicine, 2003-10, Vol.97 (10), p.1120-1125 |
| issn | 0954-6111 1532-3064 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenergic beta-2 Receptor Antagonists Adult Airway management Airway systems Asthma Asthma - physiopathology Biological and medical sciences Bronchial Provocation Tests Bronchoconstriction - drug effects Bronchoconstriction - physiology Bronchoconstrictor Agents - adverse effects Bronchodilator Agents - adverse effects Chronic obstructive pulmonary disease, asthma Dyspnea - chemically induced Dyspnea - psychology Female Forced Expiratory Volume - drug effects Humans Influence of bronchoconstriction and bronchodilation Male Medical sciences Methacholine Chloride Mortality Perception Perception of dyspnea Pneumology |
| title | The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma |
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