Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats
The moxidectin (MXD) is an antiparasitic drug used in domestic animals. The mechanism of action, in mammals, involves GABA, a neurotransmitter with an important role in the sexual behavior control. Presently, the effects of 0.2 mg/kg therapeutic dose were studied on sexual behavior, sexual motivatio...
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| Veröffentlicht in: | Research in veterinary science 2008-02, Vol.84 (1), p.100-106 |
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| creator | Rodrigues-Alves, Patricia S.B. Lebrun, Ivo Flório, Jorge Camilo Bernardi, Maria M. Spinosa, Helenice de S. |
| description | The moxidectin (MXD) is an antiparasitic drug used in domestic animals. The mechanism of action, in mammals, involves GABA, a neurotransmitter with an important role in the sexual behavior control. Presently, the effects of 0.2
mg/kg therapeutic dose were studied on sexual behavior, sexual motivation, penile erection and central GABA levels. Sexual behavior results showed increased latencies to the first mount and intromission as well as in inter-intromission interval; a reduction in total mounts was detected on the drug post-treatment. No difference was observed between sexual motivation of control and experimental animals. MXD treatment reduced penile erection and hypothalamic GABA levels. The results suggest that MXD reduced sexual behavior and penile erection by an action on the hypothalamic GABA system. Probably, the lack of effects in the motivational test and the increased mount and intromission latencies as well as decreased total mounts could be explained as a consequence of reduced male rat erection process. |
| doi_str_mv | 10.1016/j.rvsc.2007.04.003 |
| format | Article |
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mg/kg therapeutic dose were studied on sexual behavior, sexual motivation, penile erection and central GABA levels. Sexual behavior results showed increased latencies to the first mount and intromission as well as in inter-intromission interval; a reduction in total mounts was detected on the drug post-treatment. No difference was observed between sexual motivation of control and experimental animals. MXD treatment reduced penile erection and hypothalamic GABA levels. The results suggest that MXD reduced sexual behavior and penile erection by an action on the hypothalamic GABA system. Probably, the lack of effects in the motivational test and the increased mount and intromission latencies as well as decreased total mounts could be explained as a consequence of reduced male rat erection process.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2007.04.003</identifier><identifier>PMID: 17559896</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>adrenergic receptors ; adverse effects ; animal models ; Animals ; Anthelmintics - adverse effects ; chemical concentration ; copulation ; dosage ; Drug dosages ; drug evaluation ; Female ; Females ; GABA ; GABAergic receptors ; gamma-aminobutyric acid ; gamma-Aminobutyric Acid - metabolism ; hypothalamus ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Laboratory animals ; Macrolides - adverse effects ; Male ; male reproductive system ; mechanism of action ; motivation ; Moxidectin ; Nematodes ; neurophysiology ; neurotransmitters ; pathophysiology ; Penile erection ; Penile Erection - drug effects ; Rats ; Rodents ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; veterinary drugs ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2008-02, Vol.84 (1), p.100-106</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-af1e8494525fef1b513d08f504e02e014efe2426b387637a19556a506814555d3</citedby><cites>FETCH-LOGICAL-c472t-af1e8494525fef1b513d08f504e02e014efe2426b387637a19556a506814555d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2007.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17559896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues-Alves, Patricia S.B.</creatorcontrib><creatorcontrib>Lebrun, Ivo</creatorcontrib><creatorcontrib>Flório, Jorge Camilo</creatorcontrib><creatorcontrib>Bernardi, Maria M.</creatorcontrib><creatorcontrib>Spinosa, Helenice de S.</creatorcontrib><title>Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The moxidectin (MXD) is an antiparasitic drug used in domestic animals. The mechanism of action, in mammals, involves GABA, a neurotransmitter with an important role in the sexual behavior control. Presently, the effects of 0.2
mg/kg therapeutic dose were studied on sexual behavior, sexual motivation, penile erection and central GABA levels. Sexual behavior results showed increased latencies to the first mount and intromission as well as in inter-intromission interval; a reduction in total mounts was detected on the drug post-treatment. No difference was observed between sexual motivation of control and experimental animals. MXD treatment reduced penile erection and hypothalamic GABA levels. The results suggest that MXD reduced sexual behavior and penile erection by an action on the hypothalamic GABA system. Probably, the lack of effects in the motivational test and the increased mount and intromission latencies as well as decreased total mounts could be explained as a consequence of reduced male rat erection process.</description><subject>adrenergic receptors</subject><subject>adverse effects</subject><subject>animal models</subject><subject>Animals</subject><subject>Anthelmintics - adverse effects</subject><subject>chemical concentration</subject><subject>copulation</subject><subject>dosage</subject><subject>Drug dosages</subject><subject>drug evaluation</subject><subject>Female</subject><subject>Females</subject><subject>GABA</subject><subject>GABAergic receptors</subject><subject>gamma-aminobutyric acid</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>hypothalamus</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Laboratory animals</subject><subject>Macrolides - adverse effects</subject><subject>Male</subject><subject>male reproductive system</subject><subject>mechanism of action</subject><subject>motivation</subject><subject>Moxidectin</subject><subject>Nematodes</subject><subject>neurophysiology</subject><subject>neurotransmitters</subject><subject>pathophysiology</subject><subject>Penile erection</subject><subject>Penile Erection - drug effects</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>veterinary drugs</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EFr2zAUwHFROtqs6xfooRPsOntPsp5sQy9Z2bpBxw5bz0KxnxoFx8okJ7TffjIJ7DYQCMTvSeLP2I2AUoDQnzZlPKSulAB1CaoEqM7YQmAlC6m1OGeLfKIKlE1zyd6mtAEAJUR9wS5Fjdg2rV4w-hFefE_d5Efux4mio0hjRzyMPNHL3g58RWt78CF-5Dsa_UA8i-wzsGPP16-7MK3tYLe-4w_Lz0s-0IGGxIPjW5t1tFN6x944OyS6Pu1X7Onrl9_334rHnw_f75ePRadqORXWCWpUq1CiIydWKKoeGoegCCSBUORIKqlXVVPrqraiRdQWQTdCIWJfXbEPx3t3MfzZU5rMJuzjmJ80AirMS2mZlTyqLoaUIjmzi35r42tGZi5rNmYua-ayBpTJHfPQ7enq_WpL_b-RU8oM3h-Bs8HY5-iTefolQVQAjcK2xSzujiLnoYOnaFLn59i9n4uaPvj__eAv6nGSUg</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Rodrigues-Alves, Patricia S.B.</creator><creator>Lebrun, Ivo</creator><creator>Flório, Jorge Camilo</creator><creator>Bernardi, Maria M.</creator><creator>Spinosa, Helenice de S.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20080201</creationdate><title>Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats</title><author>Rodrigues-Alves, Patricia S.B. ; Lebrun, Ivo ; Flório, Jorge Camilo ; Bernardi, Maria M. ; Spinosa, Helenice de S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-af1e8494525fef1b513d08f504e02e014efe2426b387637a19556a506814555d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adrenergic receptors</topic><topic>adverse effects</topic><topic>animal models</topic><topic>Animals</topic><topic>Anthelmintics - adverse effects</topic><topic>chemical concentration</topic><topic>copulation</topic><topic>dosage</topic><topic>Drug dosages</topic><topic>drug evaluation</topic><topic>Female</topic><topic>Females</topic><topic>GABA</topic><topic>GABAergic receptors</topic><topic>gamma-aminobutyric acid</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>hypothalamus</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Laboratory animals</topic><topic>Macrolides - adverse effects</topic><topic>Male</topic><topic>male reproductive system</topic><topic>mechanism of action</topic><topic>motivation</topic><topic>Moxidectin</topic><topic>Nematodes</topic><topic>neurophysiology</topic><topic>neurotransmitters</topic><topic>pathophysiology</topic><topic>Penile erection</topic><topic>Penile Erection - drug effects</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>veterinary drugs</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigues-Alves, Patricia S.B.</creatorcontrib><creatorcontrib>Lebrun, Ivo</creatorcontrib><creatorcontrib>Flório, Jorge Camilo</creatorcontrib><creatorcontrib>Bernardi, Maria M.</creatorcontrib><creatorcontrib>Spinosa, Helenice de S.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues-Alves, Patricia S.B.</au><au>Lebrun, Ivo</au><au>Flório, Jorge Camilo</au><au>Bernardi, Maria M.</au><au>Spinosa, Helenice de S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>84</volume><issue>1</issue><spage>100</spage><epage>106</epage><pages>100-106</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The moxidectin (MXD) is an antiparasitic drug used in domestic animals. The mechanism of action, in mammals, involves GABA, a neurotransmitter with an important role in the sexual behavior control. Presently, the effects of 0.2
mg/kg therapeutic dose were studied on sexual behavior, sexual motivation, penile erection and central GABA levels. Sexual behavior results showed increased latencies to the first mount and intromission as well as in inter-intromission interval; a reduction in total mounts was detected on the drug post-treatment. No difference was observed between sexual motivation of control and experimental animals. MXD treatment reduced penile erection and hypothalamic GABA levels. The results suggest that MXD reduced sexual behavior and penile erection by an action on the hypothalamic GABA system. Probably, the lack of effects in the motivational test and the increased mount and intromission latencies as well as decreased total mounts could be explained as a consequence of reduced male rat erection process.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>17559896</pmid><doi>10.1016/j.rvsc.2007.04.003</doi><tpages>7</tpages></addata></record> |
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| subjects | adrenergic receptors adverse effects animal models Animals Anthelmintics - adverse effects chemical concentration copulation dosage Drug dosages drug evaluation Female Females GABA GABAergic receptors gamma-aminobutyric acid gamma-Aminobutyric Acid - metabolism hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Laboratory animals Macrolides - adverse effects Male male reproductive system mechanism of action motivation Moxidectin Nematodes neurophysiology neurotransmitters pathophysiology Penile erection Penile Erection - drug effects Rats Rodents Sexual behavior Sexual Behavior, Animal - drug effects veterinary drugs Veterinary medicine |
| title | Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats |
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