Pharmacokinetic and pharmacodynamic interactions of tolfenamic acid and marbofloxacin in goats

Pharmacokinetic and pharmacodynamic properties in goats of the non-steroidal anti-inflammatory drug tolfenamic acid (TA), administered both alone and in combination with the fluoroquinolone marbofloxacin (MB), were established in a tissue cage model of acute inflammation. Both drugs were injected in...

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Veröffentlicht in:	Research in veterinary science 2006-02, Vol.80 (1), p.79-90
Hauptverfasser:	Sidhu, P.K., Landoni, M.F., Lees, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve biosynthesis blood serum combination drug therapy Cross-Over Studies Dinoprostone - metabolism Drug dosages Drug Interactions Drug therapy Enzyme Inhibitors - blood Enzyme Inhibitors - pharmacokinetics Exudates and Transudates - metabolism exudation Female Fluoroquinolones - blood Fluoroquinolones - pharmacokinetics Goat Goats Goats - metabolism inflammation Inflammation - drug therapy intramuscular injection leukocyte count Leukocytes - drug effects Marbofloxacin nonsteroidal anti-inflammatory agents ortho-Aminobenzoates - blood ortho-Aminobenzoates - pharmacokinetics Pharmacodynamics Pharmacokinetics PK–PD modeling Pneumonia Prostaglandin E 2 prostaglandins quinolones Quinolones - blood Quinolones - pharmacokinetics Ratios skin temperature Thromboxane B 2 thromboxanes Tolfenamic acid Veterinary medicine
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