Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy
Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exc...
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| Veröffentlicht in: | Human pathology 2009-07, Vol.40 (7), p.1040-1044 |
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| creator | Rossi, Sabrina, MD Canal, Fabio, MD Licci, Stefano, MD Zanatta, Lucia, BSc Laurino, Licia, MD Gottardi, Michele, MD Gherlinzoni, Filippo, MD Dei Tos, Angelo Paolo, MD |
| description | Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exceptional case of metastatic myxoid liposarcoma of the spine associated with therapy-related refractory anemia with excess of blasts in a 37-year-old woman who underwent multi-agent chemotherapy for a myxoid liposarcoma of the left thigh. Microscopic examination of the bone marrow biopsy revealed dysplastic features, with abnormal localization of immature precursors and micromegakaryocytes, and islands of undifferentiated oval small/medium-size cells, suggestive of acute myeloid leukemia arising in the setting of a myelodysplastic syndrome. Immunohistochemistry was not discriminant. Cytogenetic analyses of bone marrow aspirate disclosed the presence of 2 different rearrangements, subsequently confirmed by fluorescent in situ hybridization and was crucial in making the correct diagnosis. |
| doi_str_mv | 10.1016/j.humpath.2008.12.020 |
| format | Article |
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Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exceptional case of metastatic myxoid liposarcoma of the spine associated with therapy-related refractory anemia with excess of blasts in a 37-year-old woman who underwent multi-agent chemotherapy for a myxoid liposarcoma of the left thigh. Microscopic examination of the bone marrow biopsy revealed dysplastic features, with abnormal localization of immature precursors and micromegakaryocytes, and islands of undifferentiated oval small/medium-size cells, suggestive of acute myeloid leukemia arising in the setting of a myelodysplastic syndrome. Immunohistochemistry was not discriminant. Cytogenetic analyses of bone marrow aspirate disclosed the presence of 2 different rearrangements, subsequently confirmed by fluorescent in situ hybridization and was crucial in making the correct diagnosis.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2008.12.020</identifier><identifier>PMID: 19439345</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anemia, Refractory - pathology ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biological and medical sciences ; Bone Marrow Cells - pathology ; Bone metastasis ; Chromosomes, Human, Pair 11 ; Combined Modality Therapy - adverse effects ; cytogenetics ; Diseases of the osteoarticular system ; Female ; FISH ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemia, Myeloid, Acute - pathology ; Liposarcoma, Myxoid - pathology ; Liposarcoma, Myxoid - secondary ; Medical sciences ; Myelodysplastic Syndromes - pathology ; Myxoid liposarcoma ; Neoplasms, Second Primary - pathology ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; RAEB ; Soft Tissue Neoplasms - pathology ; Therapy-related myelodysplastic syndrome ; Thigh - pathology ; Tumors of striated muscle and skeleton</subject><ispartof>Human pathology, 2009-07, Vol.40 (7), p.1040-1044</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-6e687c757b9cbdd176cd33b11d7e9f45ce42bf79aeee6e30b693b8b2a177c8933</citedby><cites>FETCH-LOGICAL-c476t-6e687c757b9cbdd176cd33b11d7e9f45ce42bf79aeee6e30b693b8b2a177c8933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817709000471$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21694623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19439345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rossi, Sabrina, MD</creatorcontrib><creatorcontrib>Canal, Fabio, MD</creatorcontrib><creatorcontrib>Licci, Stefano, MD</creatorcontrib><creatorcontrib>Zanatta, Lucia, BSc</creatorcontrib><creatorcontrib>Laurino, Licia, MD</creatorcontrib><creatorcontrib>Gottardi, Michele, MD</creatorcontrib><creatorcontrib>Gherlinzoni, Filippo, MD</creatorcontrib><creatorcontrib>Dei Tos, Angelo Paolo, MD</creatorcontrib><title>Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exceptional case of metastatic myxoid liposarcoma of the spine associated with therapy-related refractory anemia with excess of blasts in a 37-year-old woman who underwent multi-agent chemotherapy for a myxoid liposarcoma of the left thigh. Microscopic examination of the bone marrow biopsy revealed dysplastic features, with abnormal localization of immature precursors and micromegakaryocytes, and islands of undifferentiated oval small/medium-size cells, suggestive of acute myeloid leukemia arising in the setting of a myelodysplastic syndrome. Immunohistochemistry was not discriminant. Cytogenetic analyses of bone marrow aspirate disclosed the presence of 2 different rearrangements, subsequently confirmed by fluorescent in situ hybridization and was crucial in making the correct diagnosis.</description><subject>Adult</subject><subject>Anemia, Refractory - pathology</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - pathology</subject><subject>Bone metastasis</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Combined Modality Therapy - adverse effects</subject><subject>cytogenetics</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>FISH</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Liposarcoma, Myxoid - pathology</subject><subject>Liposarcoma, Myxoid - secondary</subject><subject>Medical sciences</subject><subject>Myelodysplastic Syndromes - pathology</subject><subject>Myxoid liposarcoma</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>RAEB</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Therapy-related myelodysplastic syndrome</subject><subject>Thigh - pathology</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklur1DAUhYsonvHoT1AC4mNrLm3SvCgyeIMDPqjPIZddJ2Pb1CRztP56U2bwgC8-JYRv7b32yq6qpwQ3BBP-8tgcTtOi86GhGPcNoQ2m-F61Ix2jdc8kvV_tMG553RMhrqpHKR0xJqRru4fVFZEtk6ztdtXv_ZrDN5ghe4vg1juYLaAwoAmyTllvz9P6K3iHRr-EpKMNk0Z6digfIOplrSOMOoMrGIzBrWkZi7DI0jq7GCZAfkYamTADmnSM4ScyPixpfVw9GPSY4MnlvK6-vnv7Zf-hvvn0_uP-zU1tW8FzzYH3wopOGGmNc0Rw6xgzhDgBcmg7Cy01g5AaADgwbLhkpjdUl7ltLxm7rp6f6y4x_DhByuoYTnEuLRXBrO1F37GN6s6UjSGlCINaoi9-1wKpLXF1VJfE1Za4IlSVxIvu2aX6yUzg7lSXiAvw4gLoZPU4RD1bn_5ylHDZcroZeH3moGRx6yGqZP32G85HsFm54P9r5dU_FezoZ1-afocV0t3UKhWB-rytx7YdWOJyFYT9AVLbuag</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Rossi, Sabrina, MD</creator><creator>Canal, Fabio, MD</creator><creator>Licci, Stefano, MD</creator><creator>Zanatta, Lucia, BSc</creator><creator>Laurino, Licia, MD</creator><creator>Gottardi, Michele, MD</creator><creator>Gherlinzoni, Filippo, MD</creator><creator>Dei Tos, Angelo Paolo, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20090701</creationdate><title>Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy</title><author>Rossi, Sabrina, MD ; Canal, Fabio, MD ; Licci, Stefano, MD ; Zanatta, Lucia, BSc ; Laurino, Licia, MD ; Gottardi, Michele, MD ; Gherlinzoni, Filippo, MD ; Dei Tos, Angelo Paolo, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-6e687c757b9cbdd176cd33b11d7e9f45ce42bf79aeee6e30b693b8b2a177c8933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anemia, Refractory - pathology</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - pathology</topic><topic>Bone metastasis</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Combined Modality Therapy - adverse effects</topic><topic>cytogenetics</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>FISH</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Liposarcoma, Myxoid - pathology</topic><topic>Liposarcoma, Myxoid - secondary</topic><topic>Medical sciences</topic><topic>Myelodysplastic Syndromes - pathology</topic><topic>Myxoid liposarcoma</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>RAEB</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Therapy-related myelodysplastic syndrome</topic><topic>Thigh - pathology</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossi, Sabrina, MD</creatorcontrib><creatorcontrib>Canal, Fabio, MD</creatorcontrib><creatorcontrib>Licci, Stefano, MD</creatorcontrib><creatorcontrib>Zanatta, Lucia, BSc</creatorcontrib><creatorcontrib>Laurino, Licia, MD</creatorcontrib><creatorcontrib>Gottardi, Michele, MD</creatorcontrib><creatorcontrib>Gherlinzoni, Filippo, MD</creatorcontrib><creatorcontrib>Dei Tos, Angelo Paolo, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rossi, Sabrina, MD</au><au>Canal, Fabio, MD</au><au>Licci, Stefano, MD</au><au>Zanatta, Lucia, BSc</au><au>Laurino, Licia, MD</au><au>Gottardi, Michele, MD</au><au>Gherlinzoni, Filippo, MD</au><au>Dei Tos, Angelo Paolo, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>40</volume><issue>7</issue><spage>1040</spage><epage>1044</epage><pages>1040-1044</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Myxoid liposarcoma exhibits a peculiar clinical behavior, with a tendency to spread to serosal membranes, distant soft tissues, and bones, even in the absence of lung metastases. Therapy-related hematological neoplasms are well-known side effects of cytotoxic chemotherapy. We describe an exceptional case of metastatic myxoid liposarcoma of the spine associated with therapy-related refractory anemia with excess of blasts in a 37-year-old woman who underwent multi-agent chemotherapy for a myxoid liposarcoma of the left thigh. Microscopic examination of the bone marrow biopsy revealed dysplastic features, with abnormal localization of immature precursors and micromegakaryocytes, and islands of undifferentiated oval small/medium-size cells, suggestive of acute myeloid leukemia arising in the setting of a myelodysplastic syndrome. Immunohistochemistry was not discriminant. Cytogenetic analyses of bone marrow aspirate disclosed the presence of 2 different rearrangements, subsequently confirmed by fluorescent in situ hybridization and was crucial in making the correct diagnosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19439345</pmid><doi>10.1016/j.humpath.2008.12.020</doi><tpages>5</tpages></addata></record> |
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| ispartof | Human pathology, 2009-07, Vol.40 (7), p.1040-1044 |
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| subjects | Adult Anemia, Refractory - pathology Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Bone Marrow Cells - pathology Bone metastasis Chromosomes, Human, Pair 11 Combined Modality Therapy - adverse effects cytogenetics Diseases of the osteoarticular system Female FISH Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Myeloid, Acute - pathology Liposarcoma, Myxoid - pathology Liposarcoma, Myxoid - secondary Medical sciences Myelodysplastic Syndromes - pathology Myxoid liposarcoma Neoplasms, Second Primary - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RAEB Soft Tissue Neoplasms - pathology Therapy-related myelodysplastic syndrome Thigh - pathology Tumors of striated muscle and skeleton |
| title | Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy |
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