Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression
Summary Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies. To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarr...
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| Veröffentlicht in: | Human pathology 2007-08, Vol.38 (8), p.1248-1255 |
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| creator | Yu, Miao, MD, PhD Zheng, Huachuan, MD, PhD Tsuneyama, Koichi, MD, PhD Takahashi, Hiroyuki, MD, PhD Nomoto, Kazuhiro, MD, PhD Xu, Huimian, MD, PhD Takano, Yasuo, MD, PhD |
| description | Summary Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies. To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarrays containing gastric carcinoma (n = 237 ), normal gastric mucosa (n = 23 ), intestinal metaplasia (n = 38), and adenoma (n = 42); and the findings were compared with clinicopathological parameters. Furthermore, maspin expression in the gastric carcinoma cell lines (HCG-27, MKN28, and MKN45) was examined by immunohistochemistry and Western blotting. We found that cytoplasmic and nuclear maspin expression paralleled each other ( P < .05) and decreased from intestinal metaplasia, adenoma, and carcinoma to normal gastric mucosa ( P < .05). A significant positive association was noted with depth of invasion, lymphatic invasion, lymph node metastasis, and TNM stage ( P < .05) but not with sex or Lauren's classification ( P > .05). Univariate and multivariate analyses indicated that expression of maspin correlated negatively with cumulative patient survival in gastric carcinoma ( P < .05) but was not an independent factor in the prognosis. The 2 independent factors, depth of invasion and lymphatic invasion, influenced the relation between nuclear maspin expression and survival, whereas only depth of invasion correlated with cytoplasmic maspin. Our study indicated that maspin expression experiences upregulation in gastric precancerous lesions and then slight downregulation with malignant transformation. High expression may paradoxically promote invasion and metastasis of gastric carcinomas and could be considered a good marker for the pathobiological behaviors of gastric carcinomas. |
| doi_str_mv | 10.1016/j.humpath.2006.11.025 |
| format | Article |
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To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarrays containing gastric carcinoma (n = 237 ), normal gastric mucosa (n = 23 ), intestinal metaplasia (n = 38), and adenoma (n = 42); and the findings were compared with clinicopathological parameters. Furthermore, maspin expression in the gastric carcinoma cell lines (HCG-27, MKN28, and MKN45) was examined by immunohistochemistry and Western blotting. We found that cytoplasmic and nuclear maspin expression paralleled each other ( P < .05) and decreased from intestinal metaplasia, adenoma, and carcinoma to normal gastric mucosa ( P < .05). A significant positive association was noted with depth of invasion, lymphatic invasion, lymph node metastasis, and TNM stage ( P < .05) but not with sex or Lauren's classification ( P > .05). Univariate and multivariate analyses indicated that expression of maspin correlated negatively with cumulative patient survival in gastric carcinoma ( P < .05) but was not an independent factor in the prognosis. The 2 independent factors, depth of invasion and lymphatic invasion, influenced the relation between nuclear maspin expression and survival, whereas only depth of invasion correlated with cytoplasmic maspin. Our study indicated that maspin expression experiences upregulation in gastric precancerous lesions and then slight downregulation with malignant transformation. High expression may paradoxically promote invasion and metastasis of gastric carcinomas and could be considered a good marker for the pathobiological behaviors of gastric carcinomas.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2006.11.025</identifier><identifier>PMID: 17490717</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - secondary ; Adenoma - metabolism ; Adenoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinogenesis ; Cell Nucleus - metabolism ; Cell Nucleus - pathology ; Confidence intervals ; Cytoplasm - metabolism ; Cytoplasm - pathology ; Disease Progression ; Female ; Fluorescent Antibody Technique, Direct ; Gastric carcinoma ; Gastroenterology. Liver. Pancreas. Abdomen ; Genes ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymph Nodes - pathology ; Male ; Maspin ; Medical sciences ; Metaplasia ; Middle Aged ; Multivariate analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Precancerous Conditions - metabolism ; Precancerous Conditions - pathology ; Proteins ; Serpins - metabolism ; Stomach - metabolism ; Stomach - pathology ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Tissue Array Analysis ; Tumors</subject><ispartof>Human pathology, 2007-08, Vol.38 (8), p.1248-1255</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-4c66dd193d642a0adc14c915db11f5236168adc0c531249302b17f97f0e1b3f3</citedby><cites>FETCH-LOGICAL-c476t-4c66dd193d642a0adc14c915db11f5236168adc0c531249302b17f97f0e1b3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2006.11.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18948651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17490717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Miao, MD, PhD</creatorcontrib><creatorcontrib>Zheng, Huachuan, MD, PhD</creatorcontrib><creatorcontrib>Tsuneyama, Koichi, MD, PhD</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki, MD, PhD</creatorcontrib><creatorcontrib>Nomoto, Kazuhiro, MD, PhD</creatorcontrib><creatorcontrib>Xu, Huimian, MD, PhD</creatorcontrib><creatorcontrib>Takano, Yasuo, MD, PhD</creatorcontrib><title>Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies. To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarrays containing gastric carcinoma (n = 237 ), normal gastric mucosa (n = 23 ), intestinal metaplasia (n = 38), and adenoma (n = 42); and the findings were compared with clinicopathological parameters. Furthermore, maspin expression in the gastric carcinoma cell lines (HCG-27, MKN28, and MKN45) was examined by immunohistochemistry and Western blotting. We found that cytoplasmic and nuclear maspin expression paralleled each other ( P < .05) and decreased from intestinal metaplasia, adenoma, and carcinoma to normal gastric mucosa ( P < .05). A significant positive association was noted with depth of invasion, lymphatic invasion, lymph node metastasis, and TNM stage ( P < .05) but not with sex or Lauren's classification ( P > .05). Univariate and multivariate analyses indicated that expression of maspin correlated negatively with cumulative patient survival in gastric carcinoma ( P < .05) but was not an independent factor in the prognosis. The 2 independent factors, depth of invasion and lymphatic invasion, influenced the relation between nuclear maspin expression and survival, whereas only depth of invasion correlated with cytoplasmic maspin. Our study indicated that maspin expression experiences upregulation in gastric precancerous lesions and then slight downregulation with malignant transformation. High expression may paradoxically promote invasion and metastasis of gastric carcinomas and could be considered a good marker for the pathobiological behaviors of gastric carcinomas.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinogenesis</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Confidence intervals</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoplasm - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Direct</subject><subject>Gastric carcinoma</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genes</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Maspin</subject><subject>Medical sciences</subject><subject>Metaplasia</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Precancerous Conditions - metabolism</subject><subject>Precancerous Conditions - pathology</subject><subject>Proteins</subject><subject>Serpins - metabolism</subject><subject>Stomach - metabolism</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Tissue Array Analysis</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkm2L1DAQgIMo3t7pT1AK4sfWmby2flDk8A0OFLzvIZuku1l305p0z7t_b8pWFvwiBAKZZ2aSJ0PIC4QGAeWbXbM9HkYzbRsKIBvEBqh4RFYoGK1b1tHHZAXAZd2iUhfkMucdAKLg4im5QMU7UKhWZPPdJOOG-2DNvvL3Y_I5hyFWQ18dTB5DrMramDylYCtrkg1xKIG3lR1S8nszzfDvMG3_Bjc--hxyZaKrxjRsloLPyJPe7LN_vuxX5PbTx9vrL_XNt89frz_c1JYrOdXcSukcdsxJTg0YZ5HbDoVbI_aCMomyLYdgBUPKOwZ0jarvVA8e16xnV-TVqWxp_evo86R3wzHF0lEjMN4qypUqlDhRNg05J9_rMYWDSQ8F0rNdvdOLXT3b1Yi62C15L5fqx_XBu3PWorMArxfA5CK0TybakM9c2_FWCizc-xPni4q74JPONvhovQvJ20m7Ifz3Ku_-qWD3Ic6_-NM_-Hx-tc5Ug_4xj8I8CaAAQHSK_QFiNLEd</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Yu, Miao, MD, PhD</creator><creator>Zheng, Huachuan, MD, PhD</creator><creator>Tsuneyama, Koichi, MD, PhD</creator><creator>Takahashi, Hiroyuki, MD, PhD</creator><creator>Nomoto, Kazuhiro, MD, PhD</creator><creator>Xu, Huimian, MD, PhD</creator><creator>Takano, Yasuo, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20070801</creationdate><title>Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression</title><author>Yu, Miao, MD, PhD ; Zheng, Huachuan, MD, PhD ; Tsuneyama, Koichi, MD, PhD ; Takahashi, Hiroyuki, MD, PhD ; Nomoto, Kazuhiro, MD, PhD ; Xu, Huimian, MD, PhD ; Takano, Yasuo, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-4c66dd193d642a0adc14c915db11f5236168adc0c531249302b17f97f0e1b3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinogenesis</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Nucleus - pathology</topic><topic>Confidence intervals</topic><topic>Cytoplasm - metabolism</topic><topic>Cytoplasm - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Direct</topic><topic>Gastric carcinoma</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genes</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Maspin</topic><topic>Medical sciences</topic><topic>Metaplasia</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Precancerous Conditions - metabolism</topic><topic>Precancerous Conditions - pathology</topic><topic>Proteins</topic><topic>Serpins - metabolism</topic><topic>Stomach - metabolism</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Tissue Array Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Miao, MD, PhD</creatorcontrib><creatorcontrib>Zheng, Huachuan, MD, PhD</creatorcontrib><creatorcontrib>Tsuneyama, Koichi, MD, PhD</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki, MD, PhD</creatorcontrib><creatorcontrib>Nomoto, Kazuhiro, MD, PhD</creatorcontrib><creatorcontrib>Xu, Huimian, MD, PhD</creatorcontrib><creatorcontrib>Takano, Yasuo, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Miao, MD, PhD</au><au>Zheng, Huachuan, MD, PhD</au><au>Tsuneyama, Koichi, MD, PhD</au><au>Takahashi, Hiroyuki, MD, PhD</au><au>Nomoto, Kazuhiro, MD, PhD</au><au>Xu, Huimian, MD, PhD</au><au>Takano, Yasuo, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>38</volume><issue>8</issue><spage>1248</spage><epage>1255</epage><pages>1248-1255</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Maspin, a serine protease inhibitor related to the serpin family, can suppress invasion and metastasis of malignancies. To clarify the role of maspin in the genesis and progression of gastric carcinomas, its expression pattern and level were studied by immunohistochemistry on tissue microarrays containing gastric carcinoma (n = 237 ), normal gastric mucosa (n = 23 ), intestinal metaplasia (n = 38), and adenoma (n = 42); and the findings were compared with clinicopathological parameters. Furthermore, maspin expression in the gastric carcinoma cell lines (HCG-27, MKN28, and MKN45) was examined by immunohistochemistry and Western blotting. We found that cytoplasmic and nuclear maspin expression paralleled each other ( P < .05) and decreased from intestinal metaplasia, adenoma, and carcinoma to normal gastric mucosa ( P < .05). A significant positive association was noted with depth of invasion, lymphatic invasion, lymph node metastasis, and TNM stage ( P < .05) but not with sex or Lauren's classification ( P > .05). Univariate and multivariate analyses indicated that expression of maspin correlated negatively with cumulative patient survival in gastric carcinoma ( P < .05) but was not an independent factor in the prognosis. The 2 independent factors, depth of invasion and lymphatic invasion, influenced the relation between nuclear maspin expression and survival, whereas only depth of invasion correlated with cytoplasmic maspin. Our study indicated that maspin expression experiences upregulation in gastric precancerous lesions and then slight downregulation with malignant transformation. High expression may paradoxically promote invasion and metastasis of gastric carcinomas and could be considered a good marker for the pathobiological behaviors of gastric carcinomas.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17490717</pmid><doi>10.1016/j.humpath.2006.11.025</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Adenoma - metabolism Adenoma - pathology Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinogenesis Cell Nucleus - metabolism Cell Nucleus - pathology Confidence intervals Cytoplasm - metabolism Cytoplasm - pathology Disease Progression Female Fluorescent Antibody Technique, Direct Gastric carcinoma Gastroenterology. Liver. Pancreas. Abdomen Genes Humans Investigative techniques, diagnostic techniques (general aspects) Lymph Nodes - pathology Male Maspin Medical sciences Metaplasia Middle Aged Multivariate analysis Neoplasm Invasiveness Neoplasm Staging Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Precancerous Conditions - metabolism Precancerous Conditions - pathology Proteins Serpins - metabolism Stomach - metabolism Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tissue Array Analysis Tumors |
| title | Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression |
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