Segmental determination of ethyl glucuronide in hair: A pilot study
Abstract Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abus...
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| Veröffentlicht in: | Forensic science international 2007-12, Vol.173 (2), p.87-92 |
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| creator | Appenzeller, Brice M.R Agirman, Resmi Neuberg, Paul Yegles, Michel Wennig, Robert |
| description | Abstract Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation ( rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake. |
| doi_str_mv | 10.1016/j.forsciint.2007.01.025 |
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Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation ( rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2007.01.025</identifier><identifier>PMID: 17337139</identifier><identifier>CODEN: FSINDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Alanine Transaminase - blood ; Alcohol consumption ; Alcohol use ; Alcoholism - diagnosis ; Alcoholism - metabolism ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers ; Biomarkers - metabolism ; Ethanol ; Ethyl glucuronide ; Female ; Forensic medicine ; Forensic sciences ; Forensic Toxicology ; gamma-Glutamyltransferase - blood ; Gas Chromatography-Mass Spectrometry ; General aspects ; Glucuronates - metabolism ; Hair ; Hair - metabolism ; Hair segmental analysis ; Hospitalization ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Metabolites ; Middle Aged ; Pathology ; Pilot Projects ; Public health. 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Hygiene-occupational medicine ; Studies ; Substance Abuse Detection - methods</subject><ispartof>Forensic science international, 2007-12, Vol.173 (2), p.87-92</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-2071ab2bf264055cea8efeb541f57d4fdb4c6992eabbb5442dd8c7a61cb895dd3</citedby><cites>FETCH-LOGICAL-c548t-2071ab2bf264055cea8efeb541f57d4fdb4c6992eabbb5442dd8c7a61cb895dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0379073807000618$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19219330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17337139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Appenzeller, Brice M.R</creatorcontrib><creatorcontrib>Agirman, Resmi</creatorcontrib><creatorcontrib>Neuberg, Paul</creatorcontrib><creatorcontrib>Yegles, Michel</creatorcontrib><creatorcontrib>Wennig, Robert</creatorcontrib><title>Segmental determination of ethyl glucuronide in hair: A pilot study</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Abstract Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation ( rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Alcohol consumption</subject><subject>Alcohol use</subject><subject>Alcoholism - diagnosis</subject><subject>Alcoholism - metabolism</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Ethanol</subject><subject>Ethyl glucuronide</subject><subject>Female</subject><subject>Forensic medicine</subject><subject>Forensic sciences</subject><subject>Forensic Toxicology</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General aspects</subject><subject>Glucuronates - metabolism</subject><subject>Hair</subject><subject>Hair - metabolism</subject><subject>Hair segmental analysis</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Pilot Projects</subject><subject>Public health. 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Hygiene-occupational medicine</topic><topic>Studies</topic><topic>Substance Abuse Detection - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Appenzeller, Brice M.R</creatorcontrib><creatorcontrib>Agirman, Resmi</creatorcontrib><creatorcontrib>Neuberg, Paul</creatorcontrib><creatorcontrib>Yegles, Michel</creatorcontrib><creatorcontrib>Wennig, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Appenzeller, Brice M.R</au><au>Agirman, Resmi</au><au>Neuberg, Paul</au><au>Yegles, Michel</au><au>Wennig, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Segmental determination of ethyl glucuronide in hair: A pilot study</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2007-12-20</date><risdate>2007</risdate><volume>173</volume><issue>2</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><coden>FSINDR</coden><abstract>Abstract Ethyl glucuronide (EtG) is a minor metabolite of ethanol. Its detection in hair is more and more studied in both clinical and forensic context for the purpose of alcohol abuse monitoring. In this pilot study, hair specimens from 15 patients included in a treatment program after alcohol abuse cessation, were segmented and analyzed for EtG. The results were then compared to their self-reported past alcohol consumption and to their blood biomarkers values (GGT, MCV, ASAT, ALAT). EtG concentrations measured in hair varied from 8 to 261 pg/mg. The pattern of EtG concentration detected in the different hair segments matched with the drinking history of patients, displaying variations (increase and decrease) in alcohol consumption and also time of cessation. Results also demonstrated the existence of a significant correlation ( rp = 0.5357; p = 0.0390) between EtG concentration in hair and the amount of alcohol intake. Variations in the EtG concentrations with respect to hair segments may provide an overview of the drinking history of patients. Moreover, EtG concentration in hair may help to estimate the daily alcohol intake.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>17337139</pmid><doi>10.1016/j.forsciint.2007.01.025</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Alanine Transaminase - blood Alcohol consumption Alcohol use Alcoholism - diagnosis Alcoholism - metabolism Aspartate Aminotransferases - blood Biological and medical sciences Biomarkers Biomarkers - metabolism Ethanol Ethyl glucuronide Female Forensic medicine Forensic sciences Forensic Toxicology gamma-Glutamyltransferase - blood Gas Chromatography-Mass Spectrometry General aspects Glucuronates - metabolism Hair Hair - metabolism Hair segmental analysis Hospitalization Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metabolites Middle Aged Pathology Pilot Projects Public health. Hygiene Public health. Hygiene-occupational medicine Studies Substance Abuse Detection - methods |
| title | Segmental determination of ethyl glucuronide in hair: A pilot study |
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