ChREBP mediates glucose-stimulated pancreatic [beta]-cell proliferation

Glucose stimulates rodent and human [beta]-cell replication, but the intracellular signaling mechanisms are poorly understood. Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic [beta]-cells. We tested the h...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-08, Vol.61 (8), p.2004
Hauptverfasser:	Metukuri, Mallikarjuna R, Zhang, Pili, Basantani, Mahesh K, Chin, Connie, Stamateris, Rachel E, Alonso, Laura C, Takane, Karen K, Gramignoli, Roberto, Strom, Stephen C, O'Doherty, Robert M, Stewart, Andrew F, Vasavada, Rupangi C, Garcia-Ocana, Adolfo, Scott, Donald K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Care and treatment Cell cycle Cell division Cell growth Cell proliferation Diabetes Diabetes mellitus Genes Genetic aspects Glucose Liver Metabolism Pancreatic beta cells Physiological aspects Proteins Transcription factors
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