Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study

Abstract Background: Rupatadine is an oral active antihistamine and platelet-activating factor antagonist indicated for the management of allergic rhinitis and chronic urticaria in Europe. Objective: The purpose of this study was to describe the effect of the concomitant administration of azithromyc...

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Veröffentlicht in:	Clinical therapeutics 2008-09, Vol.30 (9), p.1639-1650
Hauptverfasser:	Solans, Anna, PhD, Izquierdo, Iñaki, MD, PhD, Donado, Esther, MD, Antonijoan, Rosa, MD, PhD, Peña, Juana, ChemD, Nadal, Teresa, PharmD, Carbó, Marcel-lí, PhD, Merlos, Manuel, PhD, Barbanoj, Manel, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Allergies Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Area Under Curve azithromycin Azithromycin - administration & dosage Azithromycin - adverse effects Azithromycin - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Confidence Intervals Cross-Over Studies Cyproheptadine - administration & dosage Cyproheptadine - adverse effects Cyproheptadine - analogs & derivatives Cyproheptadine - pharmacokinetics Cytochrome Dose-Response Relationship, Drug Drug Interactions drug-drug interactions Female Glycoproteins Hay fever Histamine Histamine H1 Antagonists - administration & dosage Histamine H1 Antagonists - adverse effects Histamine H1 Antagonists - pharmacokinetics Humans Internal Medicine Loratadine - administration & dosage Loratadine - adverse effects Loratadine - analogs & derivatives Loratadine - blood Loratadine - pharmacokinetics Male Medical Education Medical sciences Pharmacokinetics Pharmacology. Drug treatments Rhinitis rupatadine Safety Therapeutic Equivalency
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