Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: A multicenter, randomized, double-blind, placebo-controlled trial

Background: Buprenorphine is a potent opioid analgesic that is available in sublingual and parenteral formulations. A new formulation, buprenorphine transdermal delivery system (TDS), has been developed. Objective: The aim of this study was to compare the analgesic efficacy and tolerability of the 3...

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Veröffentlicht in:	Clinical therapeutics 2003, Vol.25 (1), p.150-168
Hauptverfasser:	Sittl, Reinhard, Griessinger, Norbert, Likar, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Sublingual Adult Aged Aged, 80 and over Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Angina pectoris Arthritis Biological and medical sciences buprenorphine Buprenorphine - administration & dosage Buprenorphine - adverse effects Buprenorphine - therapeutic use cancer pain Cancer therapies Chronic Disease Chronic pain Dosage Forms Dose-Response Relationship, Drug Double-Blind Method Drug dosages Female Fentanyl Humans Male Medical research Medical sciences Middle Aged mixed agonist/antagonist Morphine Narcotics Neoplasms - complications Neuropharmacology Older people opioids Osteoarthritis Pain - drug therapy Pain - etiology Pain management Pain Measurement Pharmacokinetics Pharmacology. Drug treatments Quality of life Sleep - drug effects Statistical methods transdermal delivery system
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