Pharmacokinetic Properties of Rosuvastatin After Single-Dose, Oral Administration in Chinese Volunteers: A Randomized, Open-Label, Three-Way Crossover Study

Abstract Background: Rosuvastatin, a 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor (“statin”), has been marketed for the treatment of patients with dyslipidemia. Objectives: The objective of this study was to assess the dose proportionality and pharmacokinetic (PK) properties of rosuvas...

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Veröffentlicht in:	Clinical therapeutics 2007-10, Vol.29 (10), p.2194-2203
Hauptverfasser:	Li, Yunxia, PhD, Jiang, Xuehua, PhD, Lan, Ke, PhD, Zhang, Ruoqi, MS, Li, Xue, MS, Jiang, Qian, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Area Under Curve Asian Continental Ancestry Group Biological and medical sciences Biological Availability China Chinese Chromatography, High Pressure Liquid Cross-Over Studies Dose-Response Relationship, Drug Fasting Female Fluorobenzenes - administration & dosage Fluorobenzenes - adverse effects Fluorobenzenes - pharmacokinetics food effect Food-Drug Interactions Hospitals, University Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Internal Medicine Male Mass Spectrometry Medical Education Medical sciences pharmacokinetics Pharmacology. Drug treatments Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - pharmacokinetics rosuvastatin Rosuvastatin Calcium sex effect Sex Factors single dose Sulfonamides - administration & dosage Sulfonamides - adverse effects Sulfonamides - pharmacokinetics
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