Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

Toll‐like receptor‐4 (Tlr‐4), a key pattern recognition receptor involved in innate immune response, is activated by saturated fatty acids (SFAs). To investigate the involvement of this receptor in obesity caused by consumption of diets high in fat, we utilized male Tlr‐4‐deficient 10ScN mice and 10...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2008-06, Vol.16 (6), p.1248-1255
Hauptverfasser:	Davis, Jeremy E, Gabler, Nicholas K, Walker-Daniels, Jennifer, Spurlock, Michael E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes adipose tissue Adipose Tissue - cytology Adipose Tissue - metabolism Adiposity - drug effects Adiposity - physiology animal disease models Animals Blood Glucose - metabolism Body fat Chemokine CCL2 - metabolism Cytokines deficiency diseases Diet diet-related diseases Dietary Fats - adverse effects Dietary Fats - pharmacology Energy Intake - physiology epididymis Fatty acids Fatty Acids - pharmacology Gene expression high fat diet hypertrophy immune response inflammation Insulin - blood Insulin Resistance - physiology Interleukin-6 - metabolism macrophage activation Macrophages - cytology Male metabolic syndrome Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains NF-kappa B - metabolism Nutrition nutrition-genotype interaction Obesity Obesity - chemically induced Obesity - metabolism Obesity - prevention & control overweight Physiology Proteins Random Allocation receptors risk reduction saturated fatty acids Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - genetics Toll-like receptor-4 (Tlr-4) Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF
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