Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras^sup G12D-LSL^ mice

The role of PI3K and MAPK pathways in tumor initiation and progression is well established; hence, several inhibitors of these pathways are currently in different stages of clinical trials. Recent studies identified a PI3K/mTOR (PF-04691502) and a MEK inhibitor (PD-0325901) with strong potency and e...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-08, Vol.70 (2), p.213
Hauptverfasser:	Simmons, Brett H, Lee, Joseph H, Lalwani, Kush, Giddabasappa, Anand, Snider, Brittany A, Wong, Anthony, Lappin, Patrick B, Eswaraka, Jeetendra, Kan, Julie L, Christensen, James G, Shojaei, Farbod
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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