[11C]Flumazenil metabolite measurement in plasma is not necessary for accurate brain benzodiazepine receptor quantification

In this work, a mathematical correction for metabolites has been validated which estimates the relative amount of [11C]flumazenil ([11C]FMZ) in the total plasma curve from the tissue kinetic data without the need for direct metabolite measurement in blood plasma samples. Kinetic data were obtained u...

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Veröffentlicht in:	European journal of nuclear medicine 2000-11, Vol.27 (11), p.1674-1683
Hauptverfasser:	SANABRIA-BOHORQUEZ, Sandra M, LABAR, Daniel, LEVEQUE, Philippe, BOL, Anne, DE VOLDER, Anne G, MICHEL, Christian, VERAART, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain Chemistry Carbon Radioisotopes Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Flumazenil - metabolism Fundamental and applied biological sciences. Psychology GABA Modulators - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Models, Biological Nervous system Radionuclide investigations Receptors, GABA-A - analysis Vertebrates: nervous system and sense organs
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