Verbal fluency as a prefrontal activation probe : a validation study using 99mTc-ECD brain SPET
This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 2000-12, Vol.27 (12), p.1800-1808 |
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| container_title | European Journal of Nuclear Medicine |
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| creator | AUDENAERT, Kurt BRANS, Boudewijn VAN LAERE, Koen LAHORTE, Philippe VERSIJPT, Jan VAN HEERINGEN, Kees DIERCKX, Rudi |
| description | This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose paradigm (resting and activation condition). Statistical parametric mapping (SPM96) was used to determine voxelwise significant changes. The letter fluency and the category fluency activation paradigm had a differential brain activation pattern. The posterior part of the left inferior prefrontal cortex (LIPC) was activated in both paradigms, with the category fluency task having an extra activation in the anterior LIPC. In the category fluency task, but not the letter fluency task, an activation in the right inferior prefrontal cortex was found. These findings confirm to a large extent the results of previous functional magnetic resonance imaging and positron emission tomography studies in semantic and phonological activation paradigms. The choice and validity of various methodological characteristics of the experimental design leading to these results are critically discussed. It is concluded that brain SPET activation with the letter fluency and category fluency paradigm under standard neuropsychological conditions in healthy volunteers is both technically and practically feasible. |
| doi_str_mv | 10.1007/s002590000351 |
| format | Article |
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Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose paradigm (resting and activation condition). Statistical parametric mapping (SPM96) was used to determine voxelwise significant changes. The letter fluency and the category fluency activation paradigm had a differential brain activation pattern. The posterior part of the left inferior prefrontal cortex (LIPC) was activated in both paradigms, with the category fluency task having an extra activation in the anterior LIPC. In the category fluency task, but not the letter fluency task, an activation in the right inferior prefrontal cortex was found. These findings confirm to a large extent the results of previous functional magnetic resonance imaging and positron emission tomography studies in semantic and phonological activation paradigms. The choice and validity of various methodological characteristics of the experimental design leading to these results are critically discussed. It is concluded that brain SPET activation with the letter fluency and category fluency paradigm under standard neuropsychological conditions in healthy volunteers is both technically and practically feasible.</description><identifier>ISSN: 0340-6997</identifier><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s002590000351</identifier><identifier>PMID: 11189943</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Cerebrovascular Circulation - physiology ; Cysteine - analogs & derivatives ; Female ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Nervous system ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Organotechnetium Compounds ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - physiology ; Radionuclide investigations ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon ; Verbal Behavior - physiology ; Word Association Tests</subject><ispartof>European Journal of Nuclear Medicine, 2000-12, Vol.27 (12), p.1800-1808</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2583-7b6f500b898ce31761fd246cbcd7bc1ff24882940b75b31a00bdd809649f66b63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=861696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11189943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AUDENAERT, Kurt</creatorcontrib><creatorcontrib>BRANS, Boudewijn</creatorcontrib><creatorcontrib>VAN LAERE, Koen</creatorcontrib><creatorcontrib>LAHORTE, Philippe</creatorcontrib><creatorcontrib>VERSIJPT, Jan</creatorcontrib><creatorcontrib>VAN HEERINGEN, Kees</creatorcontrib><creatorcontrib>DIERCKX, Rudi</creatorcontrib><title>Verbal fluency as a prefrontal activation probe : a validation study using 99mTc-ECD brain SPET</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose paradigm (resting and activation condition). Statistical parametric mapping (SPM96) was used to determine voxelwise significant changes. The letter fluency and the category fluency activation paradigm had a differential brain activation pattern. The posterior part of the left inferior prefrontal cortex (LIPC) was activated in both paradigms, with the category fluency task having an extra activation in the anterior LIPC. In the category fluency task, but not the letter fluency task, an activation in the right inferior prefrontal cortex was found. These findings confirm to a large extent the results of previous functional magnetic resonance imaging and positron emission tomography studies in semantic and phonological activation paradigms. The choice and validity of various methodological characteristics of the experimental design leading to these results are critically discussed. It is concluded that brain SPET activation with the letter fluency and category fluency paradigm under standard neuropsychological conditions in healthy volunteers is both technically and practically feasible.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cysteine - analogs & derivatives</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Organotechnetium Compounds</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - physiology</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Verbal Behavior - physiology</subject><subject>Word Association Tests</subject><issn>0340-6997</issn><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0ElLAzEYBuAgiq3L0asEBG-jWWayeJNaFygoWL0OSSaRKTOZmswU-u9NaXHLJfDm4cvHC8AZRlcYIX4dESKFROnQAu-BMWZYZhwJuQ_GiOYoY1LyETiKcZFMntPiEIwwxkLKnI5B-W6DVg10zWC9WUMVoYLLYF3ofJ9yZfp6pfq68ynttIU36X2lmrrahrEfqjUcYu0_oJTt3GTTyR3UQdUevr5M5yfgwKkm2tPdfQze7qfzyWM2e354mtzOMkMKQTOumSsQ0kIKYynmDLuK5MxoU3FtsHMkF4LIHGleaIpVolUlkGS5dIxpRo_B5XZu2vJzsLEv2zoa2zTK226IJScFEQRt4MU_uOiG4NNuJUaEcSSpwEllW2VCF2Oqo1yGulVhnVC56b3803vy57upg25t9aN3Rf_6VkWjGheUN3X8doJhJhn9Avd1hyE</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>AUDENAERT, Kurt</creator><creator>BRANS, Boudewijn</creator><creator>VAN LAERE, Koen</creator><creator>LAHORTE, Philippe</creator><creator>VERSIJPT, Jan</creator><creator>VAN HEERINGEN, Kees</creator><creator>DIERCKX, Rudi</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200012</creationdate><title>Verbal fluency as a prefrontal activation probe : a validation study using 99mTc-ECD brain SPET</title><author>AUDENAERT, Kurt ; BRANS, Boudewijn ; VAN LAERE, Koen ; LAHORTE, Philippe ; VERSIJPT, Jan ; VAN HEERINGEN, Kees ; DIERCKX, Rudi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2583-7b6f500b898ce31761fd246cbcd7bc1ff24882940b75b31a00bdd809649f66b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cysteine - analogs & derivatives</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Organotechnetium Compounds</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Prefrontal Cortex - physiology</topic><topic>Radionuclide investigations</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Verbal Behavior - physiology</topic><topic>Word Association Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AUDENAERT, Kurt</creatorcontrib><creatorcontrib>BRANS, Boudewijn</creatorcontrib><creatorcontrib>VAN LAERE, Koen</creatorcontrib><creatorcontrib>LAHORTE, Philippe</creatorcontrib><creatorcontrib>VERSIJPT, Jan</creatorcontrib><creatorcontrib>VAN HEERINGEN, Kees</creatorcontrib><creatorcontrib>DIERCKX, Rudi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AUDENAERT, Kurt</au><au>BRANS, Boudewijn</au><au>VAN LAERE, Koen</au><au>LAHORTE, Philippe</au><au>VERSIJPT, Jan</au><au>VAN HEERINGEN, Kees</au><au>DIERCKX, Rudi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Verbal fluency as a prefrontal activation probe : a validation study using 99mTc-ECD brain SPET</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>2000-12</date><risdate>2000</risdate><volume>27</volume><issue>12</issue><spage>1800</spage><epage>1808</epage><pages>1800-1808</pages><issn>0340-6997</issn><issn>1619-7070</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose paradigm (resting and activation condition). Statistical parametric mapping (SPM96) was used to determine voxelwise significant changes. The letter fluency and the category fluency activation paradigm had a differential brain activation pattern. The posterior part of the left inferior prefrontal cortex (LIPC) was activated in both paradigms, with the category fluency task having an extra activation in the anterior LIPC. In the category fluency task, but not the letter fluency task, an activation in the right inferior prefrontal cortex was found. These findings confirm to a large extent the results of previous functional magnetic resonance imaging and positron emission tomography studies in semantic and phonological activation paradigms. The choice and validity of various methodological characteristics of the experimental design leading to these results are critically discussed. It is concluded that brain SPET activation with the letter fluency and category fluency paradigm under standard neuropsychological conditions in healthy volunteers is both technically and practically feasible.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11189943</pmid><doi>10.1007/s002590000351</doi><tpages>9</tpages></addata></record> |
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| ispartof | European Journal of Nuclear Medicine, 2000-12, Vol.27 (12), p.1800-1808 |
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| subjects | Adult Biological and medical sciences Cerebrovascular Circulation - physiology Cysteine - analogs & derivatives Female Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nervous system Nervous system involvement in other diseases. Miscellaneous Neurology Organotechnetium Compounds Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Radionuclide investigations Radiopharmaceuticals Tomography, Emission-Computed, Single-Photon Verbal Behavior - physiology Word Association Tests |
| title | Verbal fluency as a prefrontal activation probe : a validation study using 99mTc-ECD brain SPET |
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