Metabolism of [123I]epidepride may affect brain dopamine D2 receptor imaging with single-photon emission tomography

Iodine-123 labelled epidepride is a novel radiopharmaceutical for the study of cerebral dopamine D2 receptors using single-photon emission tomography (SPET). A lipophilic labelled metabolite of [123I]epidepride which may enter the brain and hamper the quantitation of receptors has been observed in h...

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Veröffentlicht in:	European journal of nuclear medicine 2000-02, Vol.27 (2), p.206-208
Hauptverfasser:	BERGSTRÖM, K. A, MEIXIANG YU, KUIKKA, J. T, AKERMAN, K. K, HILTUNEN, J, LEHTONEN, J, HALLDIN, C, TIIHONEN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzamides - pharmacokinetics Biological and medical sciences Blood-Brain Barrier Brain - diagnostic imaging Brain - metabolism Chromatography, High Pressure Liquid Contrast Media Dopamine Antagonists - pharmacokinetics Humans Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Male Medical sciences Nervous system Pyrrolidines - pharmacokinetics Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Receptors, Dopamine D2 - metabolism Salicylamides - pharmacokinetics Tomography, Emission-Computed, Single-Photon
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