Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression

Various radiotracers based on uracil nucleosides (e.g. [124I]2'-fluoro-2'-deoxy-5-iodo-1-beta-D-arabinofuranosyluracil, [124I]FIAU) and acycloguanosine derivatives (e.g. [18F]9-[(3-fluoro-1-hydroxy-2-propoxy) methyl] guanine, [18F]FHPG) have been proposed for the non-invasive imaging of he...

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Veröffentlicht in:	European Journal of Nuclear Medicine 2001-06, Vol.28 (6), p.721-729
Hauptverfasser:	BRUST, Peter, HAUBNER, Roland, SCHACKERT, Gabriele, SCHACKERT, Hans K, AVRIL, Norbert, JOHANNSEN, Bernd, FRIEDRICH, Anne, SCHEUNEMANN, Matthias, ANTON, Martina, KOUFAKI, Olga-Niki, HAUSES, Martin, NOLL, Steffi, NOLL, Bernhard, HABERKORN, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antiviral Agents - pharmacology Applied cell therapy and gene therapy Arabinofuranosyluracil - analogs & derivatives Arabinofuranosyluracil - pharmacokinetics Biological and medical sciences Cell Line Cells, Cultured Endocrine glands. Genital system. Mammary gland Enzyme Inhibitors - pharmacology Ganciclovir - analogs & derivatives Ganciclovir - pharmacokinetics Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Viral - genetics Genetic Vectors Herpesvirus 1, Human - enzymology Herpesvirus 1, Human - genetics Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred BALB C Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Thymidine Kinase - antagonists & inhibitors Thymidine Kinase - biosynthesis Thymidine Kinase - genetics Tissue Distribution Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes - genetics
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