Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model
Amiodarone (AD) is a very effective anti-arrhythmic drug, but its use is often associated with serious pulmonary complications such as pneumonitis and interstitial pulmonary disease. The aim of this study was to investigate the relationship between the amount of amiodarone intake (and the related de...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 2001-03, Vol.28 (3), p.346-350 |
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| creator | KAYA, G. Capa BEKIS, R KIRIMCA, F ERTAY, T KARGI, A GURE, A DURAK, H |
| description | Amiodarone (AD) is a very effective anti-arrhythmic drug, but its use is often associated with serious pulmonary complications such as pneumonitis and interstitial pulmonary disease. The aim of this study was to investigate the relationship between the amount of amiodarone intake (and the related development of lung toxicity) and the lung uptake of technetium-99m labelled D,L-hexamethylpropylene amine oxime (HMPAO). Eighteen white female New Zealand rabbits were divided into three groups and fed AD by gavage at doses of 10 (group A), 50 (group B) or 150 (group C) mg/kg daily. 99mTc-HMPAO scintigraphy was performed at baseline and after 1, 2, 3 and 4 weeks of drug intake. Anterior images of 1 min duration were acquired at 30 min after the injection of 37 MBq 99mTc-HMPAO. Regions of interest (ROIs) were drawn on the lungs (L) and the upper limb (B) as the background. L/B ratios were calculated using the mean counts. In groups A and B histopathological evaluation of the lungs of all rabbits was performed at the end of the 4 weeks of AD intake, while in group C it was performed at 2 weeks because of increased mortality. At baseline, mean L/B ratios for groups A, B and C were 2.8 +/- 0.3, 2.8 +/- 0.3 and 2.8 +/- 0.4, respectively. After 3 weeks of AD intake, L/B ratios increased to 4.1 +/- 0.6 and 4.8 +/- 0.6 in groups A and B, respectively. The L/B ratio was 3.6 +/- 0.2 after 1 week of AD intake in group C. The correlation coefficients between the lung uptake of 99mTc-HMPAO and AD doses for groups A, B and C were r = 0.51 (P = 0.037), r = 0.74 (P = 0.0002) and r = 0.96 (P = 0.0001), respectively. Histopathological findings related to AD lung toxicity, such as interstitial pneumonitis and foamy alveolar macrophages, were observed more frequently in groups B and C than in group A. According to our findings, 99mTc-HMPAO lung uptake is correlated with AD dose. 99mTc-HMPAO lung imaging can demonstrate AD-induced lung injury. |
| doi_str_mv | 10.1007/s002590000446 |
| format | Article |
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Capa ; BEKIS, R ; KIRIMCA, F ; ERTAY, T ; KARGI, A ; GURE, A ; DURAK, H</creator><creatorcontrib>KAYA, G. Capa ; BEKIS, R ; KIRIMCA, F ; ERTAY, T ; KARGI, A ; GURE, A ; DURAK, H</creatorcontrib><description>Amiodarone (AD) is a very effective anti-arrhythmic drug, but its use is often associated with serious pulmonary complications such as pneumonitis and interstitial pulmonary disease. The aim of this study was to investigate the relationship between the amount of amiodarone intake (and the related development of lung toxicity) and the lung uptake of technetium-99m labelled D,L-hexamethylpropylene amine oxime (HMPAO). Eighteen white female New Zealand rabbits were divided into three groups and fed AD by gavage at doses of 10 (group A), 50 (group B) or 150 (group C) mg/kg daily. 99mTc-HMPAO scintigraphy was performed at baseline and after 1, 2, 3 and 4 weeks of drug intake. Anterior images of 1 min duration were acquired at 30 min after the injection of 37 MBq 99mTc-HMPAO. Regions of interest (ROIs) were drawn on the lungs (L) and the upper limb (B) as the background. L/B ratios were calculated using the mean counts. In groups A and B histopathological evaluation of the lungs of all rabbits was performed at the end of the 4 weeks of AD intake, while in group C it was performed at 2 weeks because of increased mortality. At baseline, mean L/B ratios for groups A, B and C were 2.8 +/- 0.3, 2.8 +/- 0.3 and 2.8 +/- 0.4, respectively. After 3 weeks of AD intake, L/B ratios increased to 4.1 +/- 0.6 and 4.8 +/- 0.6 in groups A and B, respectively. The L/B ratio was 3.6 +/- 0.2 after 1 week of AD intake in group C. The correlation coefficients between the lung uptake of 99mTc-HMPAO and AD doses for groups A, B and C were r = 0.51 (P = 0.037), r = 0.74 (P = 0.0002) and r = 0.96 (P = 0.0001), respectively. Histopathological findings related to AD lung toxicity, such as interstitial pneumonitis and foamy alveolar macrophages, were observed more frequently in groups B and C than in group A. According to our findings, 99mTc-HMPAO lung uptake is correlated with AD dose. 99mTc-HMPAO lung imaging can demonstrate AD-induced lung injury.</description><identifier>ISSN: 0340-6997</identifier><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s002590000446</identifier><identifier>PMID: 11315603</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Amiodarone - toxicity ; Animals ; Biological and medical sciences ; Bronchiolitis Obliterans - chemically induced ; Bronchiolitis Obliterans - diagnostic imaging ; Bronchiolitis Obliterans - pathology ; Drug toxicity and drugs side effects treatment ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - pathology ; Lung - metabolism ; Lung - pathology ; Lung Diseases - chemically induced ; Lung Diseases - diagnostic imaging ; Lung Diseases - pathology ; Medical sciences ; Pharmacology. Drug treatments ; Rabbits ; Radionuclide Imaging ; Radionuclide investigations ; Radiopharmaceuticals - pharmacokinetics ; Respiratory system ; Technetium Tc 99m Exametazime - pharmacokinetics ; Toxicity: respiratory system, ent, stomatology ; Vasodilator Agents - toxicity</subject><ispartof>European Journal of Nuclear Medicine, 2001-03, Vol.28 (3), p.346-350</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-ab00b48e13762cb5943c0755ef7965e80b5200bc18adc8b04cf89ae113dba6c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=914737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11315603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAYA, G. Capa</creatorcontrib><creatorcontrib>BEKIS, R</creatorcontrib><creatorcontrib>KIRIMCA, F</creatorcontrib><creatorcontrib>ERTAY, T</creatorcontrib><creatorcontrib>KARGI, A</creatorcontrib><creatorcontrib>GURE, A</creatorcontrib><creatorcontrib>DURAK, H</creatorcontrib><title>Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>Amiodarone (AD) is a very effective anti-arrhythmic drug, but its use is often associated with serious pulmonary complications such as pneumonitis and interstitial pulmonary disease. The aim of this study was to investigate the relationship between the amount of amiodarone intake (and the related development of lung toxicity) and the lung uptake of technetium-99m labelled D,L-hexamethylpropylene amine oxime (HMPAO). Eighteen white female New Zealand rabbits were divided into three groups and fed AD by gavage at doses of 10 (group A), 50 (group B) or 150 (group C) mg/kg daily. 99mTc-HMPAO scintigraphy was performed at baseline and after 1, 2, 3 and 4 weeks of drug intake. Anterior images of 1 min duration were acquired at 30 min after the injection of 37 MBq 99mTc-HMPAO. Regions of interest (ROIs) were drawn on the lungs (L) and the upper limb (B) as the background. L/B ratios were calculated using the mean counts. In groups A and B histopathological evaluation of the lungs of all rabbits was performed at the end of the 4 weeks of AD intake, while in group C it was performed at 2 weeks because of increased mortality. At baseline, mean L/B ratios for groups A, B and C were 2.8 +/- 0.3, 2.8 +/- 0.3 and 2.8 +/- 0.4, respectively. After 3 weeks of AD intake, L/B ratios increased to 4.1 +/- 0.6 and 4.8 +/- 0.6 in groups A and B, respectively. The L/B ratio was 3.6 +/- 0.2 after 1 week of AD intake in group C. The correlation coefficients between the lung uptake of 99mTc-HMPAO and AD doses for groups A, B and C were r = 0.51 (P = 0.037), r = 0.74 (P = 0.0002) and r = 0.96 (P = 0.0001), respectively. Histopathological findings related to AD lung toxicity, such as interstitial pneumonitis and foamy alveolar macrophages, were observed more frequently in groups B and C than in group A. According to our findings, 99mTc-HMPAO lung uptake is correlated with AD dose. 99mTc-HMPAO lung imaging can demonstrate AD-induced lung injury.</description><subject>Amiodarone - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchiolitis Obliterans - chemically induced</subject><subject>Bronchiolitis Obliterans - diagnostic imaging</subject><subject>Bronchiolitis Obliterans - pathology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - pathology</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung Diseases - chemically induced</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Lung Diseases - pathology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Respiratory system</subject><subject>Technetium Tc 99m Exametazime - pharmacokinetics</subject><subject>Toxicity: respiratory system, ent, stomatology</subject><subject>Vasodilator Agents - toxicity</subject><issn>0340-6997</issn><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpV0D1PwzAQBmALgWgpjKzIEnPgXNtxPFYIKFJRGegc2Y7TumriYjsS_fektOLjllueu9O9CF0TuCMA4j4CjLmEvhjLT9CQ5ERmAgp5ioZAGWS5lGKALmJcfxvKz9GAEEp4DnSIVotosa9xsmbV2uS6JpOywdPXt8kcR-Pa5JZBbVc7XPuA08riyvY2Od_ux1TjfKWCby3edO0SJ__pjEs77FqscFBau4QbX9nNJTqr1Sbaq2MfocXT4_vDNJvNn18eJrPMMAYpUxpAs8ISKvKx0VwyakBwbmshc24L0HzcC0MKVZlCAzN1IZXtH6q0yg3QEbo97N0G_9HZmMq170LbnywJjHMBXPC9yg7KBB9jsHW5Da5RYdejcp9r-S_X3t8ct3a6sdWvPgb556yKRm3qoFrj4o-ThAkq6BfbVH5E</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>KAYA, G. Capa</creator><creator>BEKIS, R</creator><creator>KIRIMCA, F</creator><creator>ERTAY, T</creator><creator>KARGI, A</creator><creator>GURE, A</creator><creator>DURAK, H</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20010301</creationdate><title>Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model</title><author>KAYA, G. Capa ; BEKIS, R ; KIRIMCA, F ; ERTAY, T ; KARGI, A ; GURE, A ; DURAK, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-ab00b48e13762cb5943c0755ef7965e80b5200bc18adc8b04cf89ae113dba6c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amiodarone - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchiolitis Obliterans - chemically induced</topic><topic>Bronchiolitis Obliterans - diagnostic imaging</topic><topic>Bronchiolitis Obliterans - pathology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - pathology</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung Diseases - chemically induced</topic><topic>Lung Diseases - diagnostic imaging</topic><topic>Lung Diseases - pathology</topic><topic>Medical sciences</topic><topic>Pharmacology. 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Capa</au><au>BEKIS, R</au><au>KIRIMCA, F</au><au>ERTAY, T</au><au>KARGI, A</au><au>GURE, A</au><au>DURAK, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>28</volume><issue>3</issue><spage>346</spage><epage>350</epage><pages>346-350</pages><issn>0340-6997</issn><issn>1619-7070</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>Amiodarone (AD) is a very effective anti-arrhythmic drug, but its use is often associated with serious pulmonary complications such as pneumonitis and interstitial pulmonary disease. The aim of this study was to investigate the relationship between the amount of amiodarone intake (and the related development of lung toxicity) and the lung uptake of technetium-99m labelled D,L-hexamethylpropylene amine oxime (HMPAO). Eighteen white female New Zealand rabbits were divided into three groups and fed AD by gavage at doses of 10 (group A), 50 (group B) or 150 (group C) mg/kg daily. 99mTc-HMPAO scintigraphy was performed at baseline and after 1, 2, 3 and 4 weeks of drug intake. Anterior images of 1 min duration were acquired at 30 min after the injection of 37 MBq 99mTc-HMPAO. Regions of interest (ROIs) were drawn on the lungs (L) and the upper limb (B) as the background. L/B ratios were calculated using the mean counts. In groups A and B histopathological evaluation of the lungs of all rabbits was performed at the end of the 4 weeks of AD intake, while in group C it was performed at 2 weeks because of increased mortality. At baseline, mean L/B ratios for groups A, B and C were 2.8 +/- 0.3, 2.8 +/- 0.3 and 2.8 +/- 0.4, respectively. After 3 weeks of AD intake, L/B ratios increased to 4.1 +/- 0.6 and 4.8 +/- 0.6 in groups A and B, respectively. The L/B ratio was 3.6 +/- 0.2 after 1 week of AD intake in group C. The correlation coefficients between the lung uptake of 99mTc-HMPAO and AD doses for groups A, B and C were r = 0.51 (P = 0.037), r = 0.74 (P = 0.0002) and r = 0.96 (P = 0.0001), respectively. Histopathological findings related to AD lung toxicity, such as interstitial pneumonitis and foamy alveolar macrophages, were observed more frequently in groups B and C than in group A. According to our findings, 99mTc-HMPAO lung uptake is correlated with AD dose. 99mTc-HMPAO lung imaging can demonstrate AD-induced lung injury.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11315603</pmid><doi>10.1007/s002590000446</doi><tpages>5</tpages></addata></record> |
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| subjects | Amiodarone - toxicity Animals Biological and medical sciences Bronchiolitis Obliterans - chemically induced Bronchiolitis Obliterans - diagnostic imaging Bronchiolitis Obliterans - pathology Drug toxicity and drugs side effects treatment Investigative techniques, diagnostic techniques (general aspects) Liver - pathology Lung - metabolism Lung - pathology Lung Diseases - chemically induced Lung Diseases - diagnostic imaging Lung Diseases - pathology Medical sciences Pharmacology. Drug treatments Rabbits Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Respiratory system Technetium Tc 99m Exametazime - pharmacokinetics Toxicity: respiratory system, ent, stomatology Vasodilator Agents - toxicity |
| title | Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model |
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