High uptake of L-3-[123I]iodo-[alpha]-methyl tyrosine in pilocytic astrocytomas

High uptake of L-3-[123I]iodo-[alpha]-methyl tyrosine in pilocytic astrocytomas

Despite a favourable prognosis, pilocytic astrocytomas may exhibit signs of malignancy on various neuroimaging modalities. This retrospective analysis was conducted to determine whether scintigraphic features of malignancy are also found on single-photon emission tomography (SPET) using L-3-[^sup 12...

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Veröffentlicht in:European journal of nuclear medicine and molecular imaging 2001-03, Vol.28 (3), p.273
Hauptverfasser: Weckesser, Matthias, Matheja, Peter, Rickert, Christian H, Sträter, Ronald, Palkovic, Stefan, Löttgen, Jan, Kurlemann, Gerd, Paulus, Werner, Wassmann, Hansdetlef, Schober, Otmar
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container_title European journal of nuclear medicine and molecular imaging
container_volume 28
creator Weckesser, Matthias
Matheja, Peter
Rickert, Christian H
Sträter, Ronald
Palkovic, Stefan
Löttgen, Jan
Kurlemann, Gerd
Paulus, Werner
Wassmann, Hansdetlef
Schober, Otmar
description Despite a favourable prognosis, pilocytic astrocytomas may exhibit signs of malignancy on various neuroimaging modalities. This retrospective analysis was conducted to determine whether scintigraphic features of malignancy are also found on single-photon emission tomography (SPET) using L-3-[^sup 123^I]iodo-α-methyl tyrosine (IMT) as a tracer. Twenty patients with pilocytic astrocytomas were retrospectively selected from a large series of patients referred for the evaluation of primary or recurrent brain tumours. IMT SPET was performed in 16 patients, positron emission tomography (PET) using 2-[^sup 18^F]fluoro-2-deoxy-D-glucose (FDG) was available in 10 of the patients and SPET using technetium-99m tetrofosmin or thallium-201 had been performed in 11. Image analysis was performed using standard protocols to determine how many patients exceeded the respective thresholds of malignancy. Features of malignancy were found in 7/16 IMT SPET studies, in 7/10 FDG PET studies and in 7/11 of the residual SPET investigations. A significant correlation of tumour size and IMT uptake in primary pilocytic astrocytomas indicated partial volume effects to partly account for the differential uptake behaviour (n=10, r=0.87, P
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This retrospective analysis was conducted to determine whether scintigraphic features of malignancy are also found on single-photon emission tomography (SPET) using L-3-[^sup 123^I]iodo-α-methyl tyrosine (IMT) as a tracer. Twenty patients with pilocytic astrocytomas were retrospectively selected from a large series of patients referred for the evaluation of primary or recurrent brain tumours. IMT SPET was performed in 16 patients, positron emission tomography (PET) using 2-[^sup 18^F]fluoro-2-deoxy-D-glucose (FDG) was available in 10 of the patients and SPET using technetium-99m tetrofosmin or thallium-201 had been performed in 11. Image analysis was performed using standard protocols to determine how many patients exceeded the respective thresholds of malignancy. Features of malignancy were found in 7/16 IMT SPET studies, in 7/10 FDG PET studies and in 7/11 of the residual SPET investigations. A significant correlation of tumour size and IMT uptake in primary pilocytic astrocytomas indicated partial volume effects to partly account for the differential uptake behaviour (n=10, r=0.87, P&lt;0.05). Differences in IMT uptake in primaries (1.7±0.6, n=10) and in recurrent tumours (2.3±0.7, n=6) did not attain statistical significance. IMT SPET results indicative of malignancy are regularly found in pilocytic astrocytomas, despite their good prognosis. 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title High uptake of L-3-[123I]iodo-[alpha]-methyl tyrosine in pilocytic astrocytomas
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