Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism
Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowa...
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| Veröffentlicht in: | European journal of nuclear medicine 1999-02, Vol.26 (2), p.171-182 |
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| creator | BOOIJ, J TISSINGH, G WINOGRODZKA, A VAN ROYEN, E. A |
| description | Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. This review concentrates on findings of SPET and PET studies of the dopaminergic neurotransmitter system in various parkinsonian syndromes. |
| doi_str_mv | 10.1007/s002590050374 |
| format | Article |
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A</creatorcontrib><title>Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism</title><title>European journal of nuclear medicine</title><addtitle>Eur J Nucl Med</addtitle><description>Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. 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Prion diseases</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Plasma Membrane Transport Proteins</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins</subject><subject>Membrane Transport Proteins</subject><subject>Nerve Tissue Proteins</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease, Secondary - diagnostic imaging</subject><subject>Parkinson Disease, Secondary - metabolism</subject><subject>Parkinson Disease, Secondary - pathology</subject><subject>Radionuclide investigations</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Receptors, Presynaptic</subject><subject>Tomography, Emission-Computed</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0340-6997</issn><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU-LFDEQxYMo67h69CgEFG-tlaTT3TnK4p-FBS96btLp6pms3UmbSrPMZ_HLmmFHRcFLFcX71aOKx9hzAW8EQPuWAKQ2ABpUWz9gO9EIU7XQmYdsB6qGqjGmfcyeEN0CQF0rfcEujFFKabljP64Xu_dhz-PE8wH5GFe7-IBp7x0PuKWYkw20eCIfA6cjZVz4RqeVU5mxWg8xFwl_MTkucZ_sejhyG0a-RvI5_Qfwga82ewyZ-J3PhzKlbz5QDJ6Wp-zRZGfCZ-d-yb5-eP_l6lN18_nj9dW7m8qpWucKlbSDkGqyZnKITozdMEnlnO6slg7bydZatXIYDeIABtyIUkspxsHC2Gp1yV7f-64pft-Qcl8udTjPNmDcqG-MbjoNXQFf_gPexi2FclsvQDYtCCnrQlX3lEuRKOHUr8kvNh0L1J8i6_-KrPAvzq7bsOD4mz5nVPRXZ92Ss_NU8nCe_pg2XflFqZ8UAaOr</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>BOOIJ, J</creator><creator>TISSINGH, G</creator><creator>WINOGRODZKA, A</creator><creator>VAN ROYEN, E. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-e32ab123fa9fceec1d8bf23cc58a52ce7fa45372bd9eeb090cde25221dba0d753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Carrier Proteins - metabolism</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism</atitle><jtitle>European journal of nuclear medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>26</volume><issue>2</issue><spage>171</spage><epage>182</epage><pages>171-182</pages><issn>0340-6997</issn><issn>1619-7070</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. This review concentrates on findings of SPET and PET studies of the dopaminergic neurotransmitter system in various parkinsonian syndromes.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9933352</pmid><doi>10.1007/s002590050374</doi><tpages>12</tpages></addata></record> |
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| ispartof | European journal of nuclear medicine, 1999-02, Vol.26 (2), p.171-182 |
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| subjects | Biological and medical sciences Carrier Proteins - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Nervous system Neurology Neurons - metabolism Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease, Secondary - diagnostic imaging Parkinson Disease, Secondary - metabolism Parkinson Disease, Secondary - pathology Radionuclide investigations Receptors, Dopamine D2 - metabolism Receptors, Presynaptic Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon |
| title | Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism |
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