Testicular function after radioiodine therapy for thyroid carcinoma

Radiotherapy can cause infertility in both men and women. However, few data are available concerning the effects of radioiodine therapy for thyroid carcinoma on testicular function. We investigated 25 men (age 23-73 years) with differentiated thyroid carcinoma in a longitudinal prospective trial. Fo...

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Veröffentlicht in:	European journal of nuclear medicine 2000-05, Vol.27 (5), p.503-507
Hauptverfasser:	WICHERS, M, BENZ, E, PALMEDO, H, BIERSACK, H. J, GRÜNWALD, F, KLINGMÜLLER, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Carcinoma - pathology Carcinoma - radiotherapy Carcinoma, Papillary - pathology Carcinoma, Papillary - radiotherapy Carcinoma, Papillary, Follicular - pathology Carcinoma, Papillary, Follicular - radiotherapy Endocrine glands Endocrinopathies Follicle Stimulating Hormone - blood Humans Inhibins - blood Iodine Radioisotopes - adverse effects Iodine Radioisotopes - therapeutic use Leydig Cells - radiation effects Luteinizing Hormone - blood Male Malignant tumors Medical sciences Middle Aged Organ Size - radiation effects Radiotherapy - adverse effects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Spermatogenesis - radiation effects Spermatozoa - radiation effects Testis - metabolism Testis - physiology Testis - radiation effects Testosterone - blood Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy Thyroid. Thyroid axis (diseases) Time Factors
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Zusammenfassung:	Radiotherapy can cause infertility in both men and women. However, few data are available concerning the effects of radioiodine therapy for thyroid carcinoma on testicular function. We investigated 25 men (age 23-73 years) with differentiated thyroid carcinoma in a longitudinal prospective trial. Follicle-stimulating hormone (FSH), inhibin B, luteinising hormone (LH) and testosterone were measured before (n = 25) and 3 months (n = 11), 6 months (n = 18), 12 months (n = 22), and 18 months (n = 18) after radioiodine therapy [radioiodine dose (mean +/- SEM): 9.8+/-0.89 GBq]. Before therapy, FSH was 5.4+/-0.77 IU/l; it increased significantly (P
ISSN:	0340-6997 1619-7070 1619-7089
DOI:	10.1007/s002590050535