P-391: High sensitivity C-reactive protein as a marker of changes in microcirculation
Introduction: C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome and of endothelial dysfunction (ED) as well as a good predictor of acute events, all of which are related to “atherosclerosis”. However, it is not known if it could also be an indicator of abnormal...
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| Veröffentlicht in: | American journal of hypertension 2005-05, Vol.18 (S4), p.147A-147A |
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| creator | Marquez, Judith Coca-Robinot, David Fabregate, Rosa Sanchez, Olivia Ugalde, Arturo Haurie, Jorge Monge, Begonia Fernandez, Eva Saban-Ruiz, Jose |
| description | Introduction: C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome and of endothelial dysfunction (ED) as well as a good predictor of acute events, all of which are related to “atherosclerosis”. However, it is not known if it could also be an indicator of abnormal elasticity and/or dysfunction at the microcirculatory level. AIMS: 1. To determine the prevalence of stiffness in small arteries. 2. To evaluate the forearm microcirculatory function. 3. To correlate the dysfunction and vascular stiffness with serum CRPhs levels. Methods: N=69, aged 31–81 (61,29+-1,57), 36 males, 33 females, 49 hypertensive, 41 with hyperglycemia and 10 smokers. CRPhs (mg/L) assessed by ELISA DRG Instruments. Endothelial and non-endothelial vasodilation: evaluation of antebrachial microcirculatory function using laser Doppler (Moor, DRT4). Peak-flow relative variation. Small artery elasticity index (C2)(ml/mmHgx100), systemic vascular resistance (dyne.sec.cm5), total vascular impedance (dyne.sec.cm5), estimated stroke volume (ml/beat), and cardiac output (L/min) and index (ESVI: ml/beat/m2 and ECOI: L/min/m2): HDI/PulseWave CR-2000. Normal values according to age and sex (standard tables by Hypertension Diagnostics Inc. CVProfilor). Statistical analysis: t-Student and Mann-Whitney U test. Pearson correlation, One-way ANOVA and multivariate linear regression. Results: 1. Small artery elasticity index was abnormal in 31 patients (44,9%). There was a correlation with age: 67,93+-1,76 vs 55,87+-2,10; p |
| doi_str_mv | 10.1016/j.amjhyper.2005.03.409 |
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However, it is not known if it could also be an indicator of abnormal elasticity and/or dysfunction at the microcirculatory level. AIMS: 1. To determine the prevalence of stiffness in small arteries. 2. To evaluate the forearm microcirculatory function. 3. To correlate the dysfunction and vascular stiffness with serum CRPhs levels. Methods: N=69, aged 31–81 (61,29+-1,57), 36 males, 33 females, 49 hypertensive, 41 with hyperglycemia and 10 smokers. CRPhs (mg/L) assessed by ELISA DRG Instruments. Endothelial and non-endothelial vasodilation: evaluation of antebrachial microcirculatory function using laser Doppler (Moor, DRT4). Peak-flow relative variation. Small artery elasticity index (C2)(ml/mmHgx100), systemic vascular resistance (dyne.sec.cm5), total vascular impedance (dyne.sec.cm5), estimated stroke volume (ml/beat), and cardiac output (L/min) and index (ESVI: ml/beat/m2 and ECOI: L/min/m2): HDI/PulseWave CR-2000. Normal values according to age and sex (standard tables by Hypertension Diagnostics Inc. CVProfilor). Statistical analysis: t-Student and Mann-Whitney U test. Pearson correlation, One-way ANOVA and multivariate linear regression. Results: 1. Small artery elasticity index was abnormal in 31 patients (44,9%). There was a correlation with age: 67,93+-1,76 vs 55,87+-2,10; p<0,001. In patients with abnormal C2 the CRPhs was 5,60+-0,51 vs 3,94+-0,60 (p=0,021 U-M-W) in those with normal C1. There was a linear correlation between CRPhs and C2 (r=0,245; α=1,662; CI 95% (0,06; 3,27), p=0,043) and between CRPhs and age (r=0,446; α=0,116; CI 95% (0,06; 0,173), p<0,001). If we correct the linear relation between CRP and C2 in terms of age, considered a the confounding factor, the significant relation in both variables is lost. 2. DRT4: N=20 (29 %) had an abnormal response. There was a correlation with age (66,00+-2,45 vs 58,79+-2,10; p=0,044). No significant correlation was found with CRP. Conclusions: 1- CRPhs could be an indicator of abnormal elasticity but not of microcirculatory dysfunction. 2- Age acts as a confounding factor for the CRP/C2 correlation.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1016/j.amjhyper.2005.03.409</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Endothelial Dysfunction ; High Sensitivity C-Reactive Protein ; Microcirculation</subject><ispartof>American journal of hypertension, 2005-05, Vol.18 (S4), p.147A-147A</ispartof><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Marquez, Judith</creatorcontrib><creatorcontrib>Coca-Robinot, David</creatorcontrib><creatorcontrib>Fabregate, Rosa</creatorcontrib><creatorcontrib>Sanchez, Olivia</creatorcontrib><creatorcontrib>Ugalde, Arturo</creatorcontrib><creatorcontrib>Haurie, Jorge</creatorcontrib><creatorcontrib>Monge, Begonia</creatorcontrib><creatorcontrib>Fernandez, Eva</creatorcontrib><creatorcontrib>Saban-Ruiz, Jose</creatorcontrib><title>P-391: High sensitivity C-reactive protein as a marker of changes in microcirculation</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Introduction: C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome and of endothelial dysfunction (ED) as well as a good predictor of acute events, all of which are related to “atherosclerosis”. However, it is not known if it could also be an indicator of abnormal elasticity and/or dysfunction at the microcirculatory level. AIMS: 1. To determine the prevalence of stiffness in small arteries. 2. To evaluate the forearm microcirculatory function. 3. To correlate the dysfunction and vascular stiffness with serum CRPhs levels. Methods: N=69, aged 31–81 (61,29+-1,57), 36 males, 33 females, 49 hypertensive, 41 with hyperglycemia and 10 smokers. CRPhs (mg/L) assessed by ELISA DRG Instruments. Endothelial and non-endothelial vasodilation: evaluation of antebrachial microcirculatory function using laser Doppler (Moor, DRT4). Peak-flow relative variation. Small artery elasticity index (C2)(ml/mmHgx100), systemic vascular resistance (dyne.sec.cm5), total vascular impedance (dyne.sec.cm5), estimated stroke volume (ml/beat), and cardiac output (L/min) and index (ESVI: ml/beat/m2 and ECOI: L/min/m2): HDI/PulseWave CR-2000. Normal values according to age and sex (standard tables by Hypertension Diagnostics Inc. CVProfilor). Statistical analysis: t-Student and Mann-Whitney U test. Pearson correlation, One-way ANOVA and multivariate linear regression. Results: 1. Small artery elasticity index was abnormal in 31 patients (44,9%). There was a correlation with age: 67,93+-1,76 vs 55,87+-2,10; p<0,001. In patients with abnormal C2 the CRPhs was 5,60+-0,51 vs 3,94+-0,60 (p=0,021 U-M-W) in those with normal C1. There was a linear correlation between CRPhs and C2 (r=0,245; α=1,662; CI 95% (0,06; 3,27), p=0,043) and between CRPhs and age (r=0,446; α=0,116; CI 95% (0,06; 0,173), p<0,001). If we correct the linear relation between CRP and C2 in terms of age, considered a the confounding factor, the significant relation in both variables is lost. 2. DRT4: N=20 (29 %) had an abnormal response. There was a correlation with age (66,00+-2,45 vs 58,79+-2,10; p=0,044). No significant correlation was found with CRP. Conclusions: 1- CRPhs could be an indicator of abnormal elasticity but not of microcirculatory dysfunction. 2- Age acts as a confounding factor for the CRP/C2 correlation.</description><subject>Endothelial Dysfunction</subject><subject>High Sensitivity C-Reactive Protein</subject><subject>Microcirculation</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkFFLwzAUhYMoOKd_QQI-t-a2TdL4JkOtOHCMieJLydLbLZ1rZ9KK-_dGJvh0OdyPe865hFwCi4GBuG5ivW3W-x26OGGMxyyNM6aOyAhUBpFMEn5MRixXPJJMwCk5875hjGVCwIi8zKJUwQ0t7GpNPbbe9vbL9ns6iRxqEwTSnet6tC3Vnmq61W6DjnY1NWvdrtDTsNla4zpjnRk-dG-79pyc1PrD48XfHJPF_d1iUkTT54fHye00sgp4hMj1sjLp0pjEqCzL0YgclkFjiKuZwBqkEHWNWZWyKk9AY8bzSqVgamlUOiZXh7Mh4eeAvi-bbnBtcCyBJUIoAMkDRQ9Uq_vBYblzNpTYl7pZ__5LAgtIdECs7_H7n3CbUshU8rJ4ey-n8_lTUcjXcpb-AOUeb8Y</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Marquez, Judith</creator><creator>Coca-Robinot, David</creator><creator>Fabregate, Rosa</creator><creator>Sanchez, Olivia</creator><creator>Ugalde, Arturo</creator><creator>Haurie, Jorge</creator><creator>Monge, Begonia</creator><creator>Fernandez, Eva</creator><creator>Saban-Ruiz, Jose</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200505</creationdate><title>P-391: High sensitivity C-reactive protein as a marker of changes in microcirculation</title><author>Marquez, Judith ; Coca-Robinot, David ; Fabregate, Rosa ; Sanchez, Olivia ; Ugalde, Arturo ; Haurie, Jorge ; Monge, Begonia ; Fernandez, Eva ; Saban-Ruiz, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i915-ee5abdc3bcc2c9448ec681b3bce089a06ef1766ffe4d30d821ae458d931cf7c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Endothelial Dysfunction</topic><topic>High Sensitivity C-Reactive Protein</topic><topic>Microcirculation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marquez, Judith</creatorcontrib><creatorcontrib>Coca-Robinot, David</creatorcontrib><creatorcontrib>Fabregate, Rosa</creatorcontrib><creatorcontrib>Sanchez, Olivia</creatorcontrib><creatorcontrib>Ugalde, Arturo</creatorcontrib><creatorcontrib>Haurie, Jorge</creatorcontrib><creatorcontrib>Monge, Begonia</creatorcontrib><creatorcontrib>Fernandez, Eva</creatorcontrib><creatorcontrib>Saban-Ruiz, Jose</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marquez, Judith</au><au>Coca-Robinot, David</au><au>Fabregate, Rosa</au><au>Sanchez, Olivia</au><au>Ugalde, Arturo</au><au>Haurie, Jorge</au><au>Monge, Begonia</au><au>Fernandez, Eva</au><au>Saban-Ruiz, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-391: High sensitivity C-reactive protein as a marker of changes in microcirculation</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2005-05</date><risdate>2005</risdate><volume>18</volume><issue>S4</issue><spage>147A</spage><epage>147A</epage><pages>147A-147A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Introduction: C-reactive protein (CRP) has behaved as a marker of the insulin resistance (IR) syndrome and of endothelial dysfunction (ED) as well as a good predictor of acute events, all of which are related to “atherosclerosis”. However, it is not known if it could also be an indicator of abnormal elasticity and/or dysfunction at the microcirculatory level. AIMS: 1. To determine the prevalence of stiffness in small arteries. 2. To evaluate the forearm microcirculatory function. 3. To correlate the dysfunction and vascular stiffness with serum CRPhs levels. Methods: N=69, aged 31–81 (61,29+-1,57), 36 males, 33 females, 49 hypertensive, 41 with hyperglycemia and 10 smokers. CRPhs (mg/L) assessed by ELISA DRG Instruments. Endothelial and non-endothelial vasodilation: evaluation of antebrachial microcirculatory function using laser Doppler (Moor, DRT4). Peak-flow relative variation. Small artery elasticity index (C2)(ml/mmHgx100), systemic vascular resistance (dyne.sec.cm5), total vascular impedance (dyne.sec.cm5), estimated stroke volume (ml/beat), and cardiac output (L/min) and index (ESVI: ml/beat/m2 and ECOI: L/min/m2): HDI/PulseWave CR-2000. Normal values according to age and sex (standard tables by Hypertension Diagnostics Inc. CVProfilor). Statistical analysis: t-Student and Mann-Whitney U test. Pearson correlation, One-way ANOVA and multivariate linear regression. Results: 1. Small artery elasticity index was abnormal in 31 patients (44,9%). There was a correlation with age: 67,93+-1,76 vs 55,87+-2,10; p<0,001. In patients with abnormal C2 the CRPhs was 5,60+-0,51 vs 3,94+-0,60 (p=0,021 U-M-W) in those with normal C1. There was a linear correlation between CRPhs and C2 (r=0,245; α=1,662; CI 95% (0,06; 3,27), p=0,043) and between CRPhs and age (r=0,446; α=0,116; CI 95% (0,06; 0,173), p<0,001). If we correct the linear relation between CRP and C2 in terms of age, considered a the confounding factor, the significant relation in both variables is lost. 2. DRT4: N=20 (29 %) had an abnormal response. There was a correlation with age (66,00+-2,45 vs 58,79+-2,10; p=0,044). No significant correlation was found with CRP. Conclusions: 1- CRPhs could be an indicator of abnormal elasticity but not of microcirculatory dysfunction. 2- Age acts as a confounding factor for the CRP/C2 correlation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/j.amjhyper.2005.03.409</doi></addata></record> |
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| subjects | Endothelial Dysfunction High Sensitivity C-Reactive Protein Microcirculation |
| title | P-391: High sensitivity C-reactive protein as a marker of changes in microcirculation |
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