Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells

Purpose TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The pre...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2012-08, Vol.138 (8), p.1279-1289
Hauptverfasser:	Yan, Shunchao, Qu, Xiujuan, Xu, Chong’an, Zhu, Zhitu, Zhang, Lingyun, Xu, Ling, Song, Na, Teng, Yuee, Liu, Yunpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Bufanolides - pharmacology Cancer Research Cell Line, Tumor Cell Proliferation - drug effects Cellular biology Down-Regulation - drug effects Drug resistance Drug Synergism Drug therapy Enzyme Inhibitors - pharmacology Female Gynecology. Andrology. Obstetrics Hematology Humans Internal Medicine Mammary gland diseases Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Oncology Original Paper Pharmacology. Drug treatments Proto-Oncogene Proteins c-cbl - genetics Proto-Oncogene Proteins c-cbl - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA Interference TNF-Related Apoptosis-Inducing Ligand - pharmacology Tumors Up-Regulation - drug effects Xenograft Model Antitumor Assays
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