Influence of lead on rat thoracic aorta contraction and relaxation

Low levels of lead, but not high levels, produce hypertension. This mystery has not yet been resolved. In this study we compared the in vitro vasoresponsiveness in rat thoracic aorta to low dose (10 −8 mol/L) and high dose (10 −5 mol/L and 10 −4 mol/L) lead acetate. In addition to the direct respons...

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Veröffentlicht in:	American journal of hypertension 2001-09, Vol.14 (9), p.873-878
Hauptverfasser:	Shelkovnikov, Stanislav A, Gonick, Harvey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - administration & dosage Animals aorta Aorta, Thoracic - drug effects Biological and medical sciences Calcium - administration & dosage Chemical and industrial products toxicology. Toxic occupational diseases Disease Models, Animal Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Female Hypertension - chemically induced Lead Lead - administration & dosage Lead - adverse effects Male Medical sciences Metals and various inorganic compounds Models, Cardiovascular Myocardial Contraction - drug effects Norepinephrine - administration & dosage Phorbol Esters - administration & dosage Potassium Chloride - administration & dosage Rats Rats, Sprague-Dawley Toxicology vascular reactivity Vasoconstrictor Agents - administration & dosage Vasodilation - drug effects Vasodilator Agents - administration & dosage
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