Influence of lead on rat thoracic aorta contraction and relaxation
Low levels of lead, but not high levels, produce hypertension. This mystery has not yet been resolved. In this study we compared the in vitro vasoresponsiveness in rat thoracic aorta to low dose (10 −8 mol/L) and high dose (10 −5 mol/L and 10 −4 mol/L) lead acetate. In addition to the direct respons...
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| Veröffentlicht in: | American journal of hypertension 2001-09, Vol.14 (9), p.873-878 |
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| creator | Shelkovnikov, Stanislav A Gonick, Harvey C |
| description | Low levels of lead, but not high levels, produce hypertension. This mystery has not yet been resolved. In this study we compared the in vitro vasoresponsiveness in rat thoracic aorta to low dose (10
−8 mol/L) and high dose (10
−5 mol/L and 10
−4 mol/L) lead acetate. In addition to the direct response to lead, we examined reactivity to norepinephrine, acetylcholine, isoproterenol, phorbol ester, and calcium in the presence and absence of lead. Neither low-dose nor high-dose lead directly affected aortic contractile or relaxant responses. However, lead, only at the highest concentration (10
−4 mol/L), increased the contractions to calcium at all submaximal calcium concentrations. We conclude that low-dose lead must increase blood pressure indirectly through a humoral effect. The reasons for the failure of high-dose lead to influence blood pressure remain to be explored. |
| doi_str_mv | 10.1016/S0895-7061(01)02149-5 |
| format | Article |
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−8 mol/L) and high dose (10
−5 mol/L and 10
−4 mol/L) lead acetate. In addition to the direct response to lead, we examined reactivity to norepinephrine, acetylcholine, isoproterenol, phorbol ester, and calcium in the presence and absence of lead. Neither low-dose nor high-dose lead directly affected aortic contractile or relaxant responses. However, lead, only at the highest concentration (10
−4 mol/L), increased the contractions to calcium at all submaximal calcium concentrations. We conclude that low-dose lead must increase blood pressure indirectly through a humoral effect. The reasons for the failure of high-dose lead to influence blood pressure remain to be explored.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/S0895-7061(01)02149-5</identifier><identifier>PMID: 11587152</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Acetylcholine - administration & dosage ; Animals ; aorta ; Aorta, Thoracic - drug effects ; Biological and medical sciences ; Calcium - administration & dosage ; Chemical and industrial products toxicology. Toxic occupational diseases ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Endothelium, Vascular - drug effects ; Female ; Hypertension - chemically induced ; Lead ; Lead - administration & dosage ; Lead - adverse effects ; Male ; Medical sciences ; Metals and various inorganic compounds ; Models, Cardiovascular ; Myocardial Contraction - drug effects ; Norepinephrine - administration & dosage ; Phorbol Esters - administration & dosage ; Potassium Chloride - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Toxicology ; vascular reactivity ; Vasoconstrictor Agents - administration & dosage ; Vasodilation - drug effects ; Vasodilator Agents - administration & dosage]]></subject><ispartof>American journal of hypertension, 2001-09, Vol.14 (9), p.873-878</ispartof><rights>2001 American Journal of Hypertension, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-124317345bc07b1e5863e0ab2c0af0868a86de9cb819ec20f53a2d7fb9ec9b0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14065147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11587152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shelkovnikov, Stanislav A</creatorcontrib><creatorcontrib>Gonick, Harvey C</creatorcontrib><title>Influence of lead on rat thoracic aorta contraction and relaxation</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Low levels of lead, but not high levels, produce hypertension. This mystery has not yet been resolved. In this study we compared the in vitro vasoresponsiveness in rat thoracic aorta to low dose (10
−8 mol/L) and high dose (10
−5 mol/L and 10
−4 mol/L) lead acetate. In addition to the direct response to lead, we examined reactivity to norepinephrine, acetylcholine, isoproterenol, phorbol ester, and calcium in the presence and absence of lead. Neither low-dose nor high-dose lead directly affected aortic contractile or relaxant responses. However, lead, only at the highest concentration (10
−4 mol/L), increased the contractions to calcium at all submaximal calcium concentrations. We conclude that low-dose lead must increase blood pressure indirectly through a humoral effect. The reasons for the failure of high-dose lead to influence blood pressure remain to be explored.</description><subject>Acetylcholine - administration & dosage</subject><subject>Animals</subject><subject>aorta</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Biological and medical sciences</subject><subject>Calcium - administration & dosage</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Female</subject><subject>Hypertension - chemically induced</subject><subject>Lead</subject><subject>Lead - administration & dosage</subject><subject>Lead - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Models, Cardiovascular</subject><subject>Myocardial Contraction - drug effects</subject><subject>Norepinephrine - administration & dosage</subject><subject>Phorbol Esters - administration & dosage</subject><subject>Potassium Chloride - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicology</subject><subject>vascular reactivity</subject><subject>Vasoconstrictor Agents - administration & dosage</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - administration & dosage</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0d9r1TAUB_AgirtO_wSlIMJ8qJ6kza8ncfPHHU58mIL4Ek7TlOXaNTNJZf73pvay-ygEwiGfc0K-IeQphVcUqHh9CUrzWoKgJ0BfAqOtrvk9sqFK6ppq4PfJ5o4ckUcp7QCgFYI-JEeUciUpZxtyej4N4-wm66owVKPDvgpTFTFX-SpEtN5WGGLGyoYplzr7coxTX0U34i0u5WPyYMAxuSf7_Zh8-_D-69m2vvjy8fzs7UVtOdO5pqxtqGxa3lmQHXVcicYBdswCDqCEQiV6p22nqHaWwcAbZL0culLpDlxzTJ6vc29i-DW7lM0uzHEqVxoKTIhGMQ1F8VXZGFKKbjA30V9j_FOQWZIz_5IzSywGylqSM7z0PdtPn7tr1x-69lEV8GIPMFkch4iT9engWhCctrK4anUT5jm6O4C7KwZQxrWF1CvxKbvbg4g_jZCN5Gb7_YdR-vLzVr9j5lPxb1bvSry_vYsmWb_8We-js9n0wf_ndX8B3VKjUw</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Shelkovnikov, Stanislav A</creator><creator>Gonick, Harvey C</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20010901</creationdate><title>Influence of lead on rat thoracic aorta contraction and relaxation</title><author>Shelkovnikov, Stanislav A ; Gonick, Harvey C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-124317345bc07b1e5863e0ab2c0af0868a86de9cb819ec20f53a2d7fb9ec9b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acetylcholine - administration & dosage</topic><topic>Animals</topic><topic>aorta</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Biological and medical sciences</topic><topic>Calcium - administration & dosage</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Female</topic><topic>Hypertension - chemically induced</topic><topic>Lead</topic><topic>Lead - administration & dosage</topic><topic>Lead - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Models, Cardiovascular</topic><topic>Myocardial Contraction - drug effects</topic><topic>Norepinephrine - administration & dosage</topic><topic>Phorbol Esters - administration & dosage</topic><topic>Potassium Chloride - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Toxicology</topic><topic>vascular reactivity</topic><topic>Vasoconstrictor Agents - administration & dosage</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shelkovnikov, Stanislav A</creatorcontrib><creatorcontrib>Gonick, Harvey C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shelkovnikov, Stanislav A</au><au>Gonick, Harvey C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of lead on rat thoracic aorta contraction and relaxation</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>14</volume><issue>9</issue><spage>873</spage><epage>878</epage><pages>873-878</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>Low levels of lead, but not high levels, produce hypertension. This mystery has not yet been resolved. In this study we compared the in vitro vasoresponsiveness in rat thoracic aorta to low dose (10
−8 mol/L) and high dose (10
−5 mol/L and 10
−4 mol/L) lead acetate. In addition to the direct response to lead, we examined reactivity to norepinephrine, acetylcholine, isoproterenol, phorbol ester, and calcium in the presence and absence of lead. Neither low-dose nor high-dose lead directly affected aortic contractile or relaxant responses. However, lead, only at the highest concentration (10
−4 mol/L), increased the contractions to calcium at all submaximal calcium concentrations. We conclude that low-dose lead must increase blood pressure indirectly through a humoral effect. The reasons for the failure of high-dose lead to influence blood pressure remain to be explored.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11587152</pmid><doi>10.1016/S0895-7061(01)02149-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Acetylcholine - administration & dosage Animals aorta Aorta, Thoracic - drug effects Biological and medical sciences Calcium - administration & dosage Chemical and industrial products toxicology. Toxic occupational diseases Disease Models, Animal Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Female Hypertension - chemically induced Lead Lead - administration & dosage Lead - adverse effects Male Medical sciences Metals and various inorganic compounds Models, Cardiovascular Myocardial Contraction - drug effects Norepinephrine - administration & dosage Phorbol Esters - administration & dosage Potassium Chloride - administration & dosage Rats Rats, Sprague-Dawley Toxicology vascular reactivity Vasoconstrictor Agents - administration & dosage Vasodilation - drug effects Vasodilator Agents - administration & dosage |
| title | Influence of lead on rat thoracic aorta contraction and relaxation |
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