Association of increased pulse pressure with the development of heart failure in shep
The aim of this study was to assess the relationship between pulse pressure (PP) and the occurrence of heart failure (HF) in older persons with isolated systolic hypertension. Data from a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial were analyzed. A total of...
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| Veröffentlicht in: | American journal of hypertension 2001-08, Vol.14 (8), p.798-803 |
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| creator | Kostis, John B Lawrence-Nelson, Janet Ranjan, Rajiv Wilson, Alan C Kostis, William J Lacy, Clifton R |
| description | The aim of this study was to assess the relationship between pulse pressure (PP) and the occurrence of heart failure (HF) in older persons with isolated systolic hypertension. Data from a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial were analyzed. A total of 4736 persons aged ≥ 60 years with systolic blood pressure (SBP) between 160 and 219 mm Hg and diastolic blood pressure (DBP) < 90 mm Hg who participated in the Systolic Hypertension in the Elderly Program (SHEP) were studied. The main outcome measures were fatal and nonfatal HF. During 4.5 years average follow-up, fatal or nonfatal HF occurred in 160 of 4736 patients. The SBP, PP, and mean arterial pressure (MAP) were strong predictors of the development of HF (
P < .0002). Cox proportional hazards regression using time-dependent covariates and controlling for MAP indicated that HF was inversely related to DBP (
P = 0.002) and was directly related to pulse pressure (
P = 0.002). Data were similar when patients who developed myocardial infarction during follow up were excluded. These data indicate that, in older persons with isolated systolic hypertension, high pulse pressure is associated with increased risk of heart failure independently of MAP and of the occurrence of acute myocardial infarction during follow-up. |
| doi_str_mv | 10.1016/S0895-7061(01)02044-1 |
| format | Article |
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P < .0002). Cox proportional hazards regression using time-dependent covariates and controlling for MAP indicated that HF was inversely related to DBP (
P = 0.002) and was directly related to pulse pressure (
P = 0.002). Data were similar when patients who developed myocardial infarction during follow up were excluded. These data indicate that, in older persons with isolated systolic hypertension, high pulse pressure is associated with increased risk of heart failure independently of MAP and of the occurrence of acute myocardial infarction during follow-up.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/S0895-7061(01)02044-1</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; heart failure ; isolated systolic hypertension ; Medical sciences ; Pulse pressure</subject><ispartof>American journal of hypertension, 2001-08, Vol.14 (8), p.798-803</ispartof><rights>2001 American Journal of Hypertension, Ltd.</rights><rights>American Journal of Hypertension, Ltd. © 2001 by the American Journal of Hypertension, Ltd. 2001</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-20ab785f62a29eb5e6ee17f5f13f5a39f19997463dcfc76f08e9a89feee697a03</citedby><cites>FETCH-LOGICAL-c515t-20ab785f62a29eb5e6ee17f5f13f5a39f19997463dcfc76f08e9a89feee697a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1106159$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kostis, John B</creatorcontrib><creatorcontrib>Lawrence-Nelson, Janet</creatorcontrib><creatorcontrib>Ranjan, Rajiv</creatorcontrib><creatorcontrib>Wilson, Alan C</creatorcontrib><creatorcontrib>Kostis, William J</creatorcontrib><creatorcontrib>Lacy, Clifton R</creatorcontrib><creatorcontrib>for the Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group</creatorcontrib><title>Association of increased pulse pressure with the development of heart failure in shep</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>The aim of this study was to assess the relationship between pulse pressure (PP) and the occurrence of heart failure (HF) in older persons with isolated systolic hypertension. Data from a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial were analyzed. A total of 4736 persons aged ≥ 60 years with systolic blood pressure (SBP) between 160 and 219 mm Hg and diastolic blood pressure (DBP) < 90 mm Hg who participated in the Systolic Hypertension in the Elderly Program (SHEP) were studied. The main outcome measures were fatal and nonfatal HF. During 4.5 years average follow-up, fatal or nonfatal HF occurred in 160 of 4736 patients. The SBP, PP, and mean arterial pressure (MAP) were strong predictors of the development of HF (
P < .0002). Cox proportional hazards regression using time-dependent covariates and controlling for MAP indicated that HF was inversely related to DBP (
P = 0.002) and was directly related to pulse pressure (
P = 0.002). Data were similar when patients who developed myocardial infarction during follow up were excluded. These data indicate that, in older persons with isolated systolic hypertension, high pulse pressure is associated with increased risk of heart failure independently of MAP and of the occurrence of acute myocardial infarction during follow-up.</description><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>heart failure</subject><subject>isolated systolic hypertension</subject><subject>Medical sciences</subject><subject>Pulse pressure</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0F9r1TAYBvAgCh6nH0EI6IVeVN-0TdJcyZh_jrCxCzcRb0KWvqE5njU1Sad--6V2bAjCIJCb3_OEPIQ8Z_CGARNvv0CneCVBsFfAXkMNbVuxB2TDOqkqpoA_JJtb8pg8SWkHAK0QbEPOD1MK1pvsw0iDo360EU3Cnk7zPiGdIqY0R6S_fB5oHpD2eIX7MF3imJfAgCZm6ozfL8qPNA04PSWPnCnxZzf3ATn_-OHsaFsdn376fHR4XFnOeK5qMBey407UplZ4wVEgMum4Y43jplGOKaVkK5reOiuFgw6V6ZRDRKGkgeaAvFh7pxh-zpiy3oU5juVJzaAWounquimKr8rGkFJEp6foL038U5BeFtR_F9TLPBrKWRbUrORe3rSbZM3eRTNan-7CrHiuCoOVhXn6f3P1T3O1NNM1MppcZrtNmd1QAzDWLqRaiU8Zf9-J-EML2Uiut9--61Zuv_L36kSfFf9u9Vj2vvIYdbIeR4u9j2iz7oO_57vXUoWsyw</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Kostis, John B</creator><creator>Lawrence-Nelson, Janet</creator><creator>Ranjan, Rajiv</creator><creator>Wilson, Alan C</creator><creator>Kostis, William J</creator><creator>Lacy, Clifton R</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20010801</creationdate><title>Association of increased pulse pressure with the development of heart failure in shep</title><author>Kostis, John B ; Lawrence-Nelson, Janet ; Ranjan, Rajiv ; Wilson, Alan C ; Kostis, William J ; Lacy, Clifton R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-20ab785f62a29eb5e6ee17f5f13f5a39f19997463dcfc76f08e9a89feee697a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>heart failure</topic><topic>isolated systolic hypertension</topic><topic>Medical sciences</topic><topic>Pulse pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kostis, John B</creatorcontrib><creatorcontrib>Lawrence-Nelson, Janet</creatorcontrib><creatorcontrib>Ranjan, Rajiv</creatorcontrib><creatorcontrib>Wilson, Alan C</creatorcontrib><creatorcontrib>Kostis, William J</creatorcontrib><creatorcontrib>Lacy, Clifton R</creatorcontrib><creatorcontrib>for the Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kostis, John B</au><au>Lawrence-Nelson, Janet</au><au>Ranjan, Rajiv</au><au>Wilson, Alan C</au><au>Kostis, William J</au><au>Lacy, Clifton R</au><aucorp>for the Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of increased pulse pressure with the development of heart failure in shep</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>14</volume><issue>8</issue><spage>798</spage><epage>803</epage><pages>798-803</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>The aim of this study was to assess the relationship between pulse pressure (PP) and the occurrence of heart failure (HF) in older persons with isolated systolic hypertension. 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P < .0002). Cox proportional hazards regression using time-dependent covariates and controlling for MAP indicated that HF was inversely related to DBP (
P = 0.002) and was directly related to pulse pressure (
P = 0.002). Data were similar when patients who developed myocardial infarction during follow up were excluded. These data indicate that, in older persons with isolated systolic hypertension, high pulse pressure is associated with increased risk of heart failure independently of MAP and of the occurrence of acute myocardial infarction during follow-up.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><doi>10.1016/S0895-7061(01)02044-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology heart failure isolated systolic hypertension Medical sciences Pulse pressure |
| title | Association of increased pulse pressure with the development of heart failure in shep |
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