P-539: Is the regression of left ventricular hypertrophy accompanied by the decrease of ventricular arrhythmias?

The increase of arrhythmia of hypertensive left ventricular hypertrophy is correlated with the risk of sudden death. In antihypertensive treatment it is possible to achieve regression LVH, but it has not been proved what impact regression LVH has on arrhythmia markers. Methods: 75 patients with II-III stage hypertension (43 male) average age 55.9 ± 8 and LVH determinated by echocardiography have been treated for a year. Arrhythmia parameters were the following: ventricular arrhythmias have been registered after 24 hour Holter monitoring and graded according to Lown; QT dispersion and heart rate variability (HRV) have been determined by time analysis from Holter monitoring. Results: After a year treatment a significant LV mass reduction (A) has been achieved in 37 patients (51%). (See Table) Variable Before Th After Th LVMI (A) (g/m2) 172 ± 35.6 142.1 ± 25* LVMI (B) (g/m2) 152.6 ± 21.3 158.7 ± 25.8 VES (Lown) (A) 2.88 ± 1.37 2 ± 1.4* VES (Lown) (B) 2.21 ± 1.7 2.1 ± 1.48 VT and couplets (A) 15 (20.5%) 6 (8.2%)* VT and couplets (B) 9 (12.3%) 7 (9,6%) QTc dispersion (A) 61.7 ± 22.4 48.3 ± 17.7* QTc dispersion (B) 48.5 ± 21.7 50.8 ± 21.2 SDNN (A) 123.3 ± 26 129.3 ± 29.1 SDNN (B) 116.5 ± 22.2± 118.4 ± 23.4 *p