Microvascular responses to endothelin in deoxycorticosterone acetate-salt hypertensive rats

The objective of the present study was to determine if endothelin-1 played a role in the elevated peripheral resistance in deoxycorticosterone-acetate (DOCA)-salt hypertension. Radioimmunoassay showed that the concentration of endothelin-1 was higher in thoracic aorta of the DOCA-salt group than tha...

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Veröffentlicht in:	American journal of hypertension 2000-07, Vol.13 (7), p.819-826
Hauptverfasser:	Zhao, Hongli, Joshua, Irving G, Porter, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Desoxycorticosterone DOCA-salt hypertension Dose-Response Relationship, Drug endothelin antagonist Endothelin Receptor Antagonists Endothelin-1 Endothelin-1 - blood Endothelin-1 - pharmacology Experimental diseases Hypertension - chemically induced Hypertension - physiopathology Male Medical sciences microcirculation Microcirculation - drug effects Muscle, Skeletal - blood supply Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Piperidines - pharmacology rat Rats Rats, Sprague-Dawley Receptor, Endothelin A Receptor, Endothelin B Sodium Chloride
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