P-391: Prognostic significance of the left ventricular contractility index in patients with essential hypertension
The aim of the study was to assess the relationship between the left ventricular (LV) contractility index, cardiac function and extracardiac organ damage in essential hypertension (EH). We have studied 142 patients (pts) with EH, age 43–52 years, free of signs of heart failure, normal values of the...
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| Veröffentlicht in: | American journal of hypertension 2003-05, Vol.16 (S1), p.178A-178A |
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| creator | Sahakyan, Karine R. Vatinyan, Susanna Kh Nikogosyan, Karine G. Gurgenyan, Svetlana V. |
| description | The aim of the study was to assess the relationship between the left ventricular (LV) contractility index, cardiac function and extracardiac organ damage in essential hypertension (EH). We have studied 142 patients (pts) with EH, age 43–52 years, free of signs of heart failure, normal values of the LV ejection fraction and fractional shortening. From M-mode Echo midwall fractional shortening (mFS)(de Simone method), end-systolic stress ESS (Reichek method) were calculated. LV contractility index was assessed as mFS in relation to ESS(mFS/ESS). Early filling velocity (E), late filling velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT) were determined by Doppler-Echo. Albuminuria was measured as albumin to creatinine ratio (ACR). Retinal vascular changes were evaluated by direct ophthalmoscopy (Keith-Wagener classification). The prevalence of LV hypertrophy and depressed LV contractility were 68.0 and 43.0%, respectively. The pts with depressed LV contractility index showed high prevalence of LV hypertrophy (86.7% vs 32.3%, p |
| doi_str_mv | 10.1016/S0895-7061(03)00556-9 |
| format | Article |
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We have studied 142 patients (pts) with EH, age 43–52 years, free of signs of heart failure, normal values of the LV ejection fraction and fractional shortening. From M-mode Echo midwall fractional shortening (mFS)(de Simone method), end-systolic stress ESS (Reichek method) were calculated. LV contractility index was assessed as mFS in relation to ESS(mFS/ESS). Early filling velocity (E), late filling velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT) were determined by Doppler-Echo. Albuminuria was measured as albumin to creatinine ratio (ACR). Retinal vascular changes were evaluated by direct ophthalmoscopy (Keith-Wagener classification). The prevalence of LV hypertrophy and depressed LV contractility were 68.0 and 43.0%, respectively. The pts with depressed LV contractility index showed high prevalence of LV hypertrophy (86.7% vs 32.3%, p<0.001), especially eccentric hypertrophy (58.0% vs 14.2%, p<0.001). Pts with depressed mFS/ESS had longer IVRT and DT with significant difference in peak E-, A-wave and E/A ratio (IVRT-157.5±9.40 vs 120.0±10.0 ms; 292.5 ±23.4 vs 214.0±6.1 ms; E-60.5±2.43 vs 70.2±1.28 cm/s; A-71.2±2.70 vs 52.0±1.64 cm/s; E/A-0.96 ±0.04 vs 1.20 ±0.08, p<0.01 for all). IVRT and DT showed a strong relation to mFS/ESS (r=−0.67 and r=−0.69, respectively, p<0.01 for both). Moreover hypertensives with depressed mFS/ESS showed early signs of extracardiac damage namely increased ACR (3.2±0.6 vs 1.2 ±0.08, p<0.01) and serum creatinine (3.6±1.2 vs 1.0±0.06 mg%, p<0.05), a higher prevalence of retinopathy (fundoscopy grade II or beyond) compared with subjects with preserved contractility (89.0% vs 40.0%, p<0.001). Furthermore, mFS/ESS was strongly associated with ACR and serum creatinine level in an univariate analysis (r=−0.59 and r=−0.62, respectively, p<0.01 for both) and these associations were still present after stepwise multivariate analysis. Conclusion: Pts with depressed contractility show a higher prevalence of LV hypertrophy, diastolic dysfunction and early signs of extracardiac vascular damage. The evaluation of LV contractility index might improve the prognostic stratification of hypertensive pts and it might be suitable to recognize subset of pts at higher risk.]]></description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1016/S0895-7061(03)00556-9</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>cardiac function ; extracardiac organ damage ; left ventricular contractility index</subject><ispartof>American journal of hypertension, 2003-05, Vol.16 (S1), p.178A-178A</ispartof><rights>Copyright Nature Publishing Group May 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sahakyan, Karine R.</creatorcontrib><creatorcontrib>Vatinyan, Susanna Kh</creatorcontrib><creatorcontrib>Nikogosyan, Karine G.</creatorcontrib><creatorcontrib>Gurgenyan, Svetlana V.</creatorcontrib><title>P-391: Prognostic significance of the left ventricular contractility index in patients with essential hypertension</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description><![CDATA[The aim of the study was to assess the relationship between the left ventricular (LV) contractility index, cardiac function and extracardiac organ damage in essential hypertension (EH). We have studied 142 patients (pts) with EH, age 43–52 years, free of signs of heart failure, normal values of the LV ejection fraction and fractional shortening. From M-mode Echo midwall fractional shortening (mFS)(de Simone method), end-systolic stress ESS (Reichek method) were calculated. LV contractility index was assessed as mFS in relation to ESS(mFS/ESS). Early filling velocity (E), late filling velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT) were determined by Doppler-Echo. Albuminuria was measured as albumin to creatinine ratio (ACR). Retinal vascular changes were evaluated by direct ophthalmoscopy (Keith-Wagener classification). The prevalence of LV hypertrophy and depressed LV contractility were 68.0 and 43.0%, respectively. The pts with depressed LV contractility index showed high prevalence of LV hypertrophy (86.7% vs 32.3%, p<0.001), especially eccentric hypertrophy (58.0% vs 14.2%, p<0.001). Pts with depressed mFS/ESS had longer IVRT and DT with significant difference in peak E-, A-wave and E/A ratio (IVRT-157.5±9.40 vs 120.0±10.0 ms; 292.5 ±23.4 vs 214.0±6.1 ms; E-60.5±2.43 vs 70.2±1.28 cm/s; A-71.2±2.70 vs 52.0±1.64 cm/s; E/A-0.96 ±0.04 vs 1.20 ±0.08, p<0.01 for all). IVRT and DT showed a strong relation to mFS/ESS (r=−0.67 and r=−0.69, respectively, p<0.01 for both). Moreover hypertensives with depressed mFS/ESS showed early signs of extracardiac damage namely increased ACR (3.2±0.6 vs 1.2 ±0.08, p<0.01) and serum creatinine (3.6±1.2 vs 1.0±0.06 mg%, p<0.05), a higher prevalence of retinopathy (fundoscopy grade II or beyond) compared with subjects with preserved contractility (89.0% vs 40.0%, p<0.001). Furthermore, mFS/ESS was strongly associated with ACR and serum creatinine level in an univariate analysis (r=−0.59 and r=−0.62, respectively, p<0.01 for both) and these associations were still present after stepwise multivariate analysis. Conclusion: Pts with depressed contractility show a higher prevalence of LV hypertrophy, diastolic dysfunction and early signs of extracardiac vascular damage. The evaluation of LV contractility index might improve the prognostic stratification of hypertensive pts and it might be suitable to recognize subset of pts at higher risk.]]></description><subject>cardiac function</subject><subject>extracardiac organ damage</subject><subject>left ventricular contractility index</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFzUtLAzEQAOAgCtbHTxACXvSwOnnuxpuIWqH4QA_iZUmTrE1dszVJ1f57AxWdgXnAxwxCBwROCBB5-giNElUNkhwBOwYQQlZqA42I4qSqKRWbaPRHttFOSnMA4FKSEYr3FVPkDN_H4TUMKXuDk38NvvNGB-Pw0OE8c7h3XcafLuTozbLXEZuhzNpk3_u8wj5Y910qXujsi0r4y-cZdimVxesez1YLF7MLyQ9hD211uk9u_7fvoqery6eLcTW5u765OJ9UXhGotLBTKznjliszbUpYy5spN52RtFHUUiO6qeioEo7xrmbG1hY0LdlwaijbRYfrs4s4fCxdyu18WMZQPrYEqJRAuIKi8FoFnZfRtYvo33VctXo-owBM1ryQak18yu77X8S3VtasFu34-aV9YbcPk_HVpH1gP0VteYI</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Sahakyan, Karine R.</creator><creator>Vatinyan, Susanna Kh</creator><creator>Nikogosyan, Karine G.</creator><creator>Gurgenyan, Svetlana V.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200305</creationdate><title>P-391: Prognostic significance of the left ventricular contractility index in patients with essential hypertension</title><author>Sahakyan, Karine R. ; Vatinyan, Susanna Kh ; Nikogosyan, Karine G. ; Gurgenyan, Svetlana V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i910-a5dbd6434d49cb8888dd48b4cfc62892d2c5fb5f295e34f73cd7d0a2a2a842c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>cardiac function</topic><topic>extracardiac organ damage</topic><topic>left ventricular contractility index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahakyan, Karine R.</creatorcontrib><creatorcontrib>Vatinyan, Susanna Kh</creatorcontrib><creatorcontrib>Nikogosyan, Karine G.</creatorcontrib><creatorcontrib>Gurgenyan, Svetlana V.</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahakyan, Karine R.</au><au>Vatinyan, Susanna Kh</au><au>Nikogosyan, Karine G.</au><au>Gurgenyan, Svetlana V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-391: Prognostic significance of the left ventricular contractility index in patients with essential hypertension</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2003-05</date><risdate>2003</risdate><volume>16</volume><issue>S1</issue><spage>178A</spage><epage>178A</epage><pages>178A-178A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract><![CDATA[The aim of the study was to assess the relationship between the left ventricular (LV) contractility index, cardiac function and extracardiac organ damage in essential hypertension (EH). We have studied 142 patients (pts) with EH, age 43–52 years, free of signs of heart failure, normal values of the LV ejection fraction and fractional shortening. From M-mode Echo midwall fractional shortening (mFS)(de Simone method), end-systolic stress ESS (Reichek method) were calculated. LV contractility index was assessed as mFS in relation to ESS(mFS/ESS). Early filling velocity (E), late filling velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT) were determined by Doppler-Echo. Albuminuria was measured as albumin to creatinine ratio (ACR). Retinal vascular changes were evaluated by direct ophthalmoscopy (Keith-Wagener classification). The prevalence of LV hypertrophy and depressed LV contractility were 68.0 and 43.0%, respectively. The pts with depressed LV contractility index showed high prevalence of LV hypertrophy (86.7% vs 32.3%, p<0.001), especially eccentric hypertrophy (58.0% vs 14.2%, p<0.001). Pts with depressed mFS/ESS had longer IVRT and DT with significant difference in peak E-, A-wave and E/A ratio (IVRT-157.5±9.40 vs 120.0±10.0 ms; 292.5 ±23.4 vs 214.0±6.1 ms; E-60.5±2.43 vs 70.2±1.28 cm/s; A-71.2±2.70 vs 52.0±1.64 cm/s; E/A-0.96 ±0.04 vs 1.20 ±0.08, p<0.01 for all). IVRT and DT showed a strong relation to mFS/ESS (r=−0.67 and r=−0.69, respectively, p<0.01 for both). Moreover hypertensives with depressed mFS/ESS showed early signs of extracardiac damage namely increased ACR (3.2±0.6 vs 1.2 ±0.08, p<0.01) and serum creatinine (3.6±1.2 vs 1.0±0.06 mg%, p<0.05), a higher prevalence of retinopathy (fundoscopy grade II or beyond) compared with subjects with preserved contractility (89.0% vs 40.0%, p<0.001). Furthermore, mFS/ESS was strongly associated with ACR and serum creatinine level in an univariate analysis (r=−0.59 and r=−0.62, respectively, p<0.01 for both) and these associations were still present after stepwise multivariate analysis. Conclusion: Pts with depressed contractility show a higher prevalence of LV hypertrophy, diastolic dysfunction and early signs of extracardiac vascular damage. The evaluation of LV contractility index might improve the prognostic stratification of hypertensive pts and it might be suitable to recognize subset of pts at higher risk.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/S0895-7061(03)00556-9</doi></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | cardiac function extracardiac organ damage left ventricular contractility index |
| title | P-391: Prognostic significance of the left ventricular contractility index in patients with essential hypertension |
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