P-367: Influence of long-term of carvedilol and metoprolol therapy on R-R variability in younger and older adults with chronic heart failure
Recent evidence shows that beta-blockers help in preventing sudden death during chronic heart failure (CHF). Our aim in this study was to examine the effect of metoprolol and carvedilol on heart rate variability in younger and older subjects with CHF. We subdivided subjects with CHF for age (younger...
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| Veröffentlicht in: | American journal of hypertension 2002-04, Vol.15 (S3), p.164A-164A |
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| container_title | American journal of hypertension |
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| creator | Piccirillo, Gianfranco Nocco, Marialuce Naso, Camilla Moisè, Antonio Lionetti, Marco Di Carlo, Silvia Marigliano, Vincenzo |
| description | Recent evidence shows that beta-blockers help in preventing sudden death during chronic heart failure (CHF). Our aim in this study was to examine the effect of metoprolol and carvedilol on heart rate variability in younger and older subjects with CHF. We subdivided subjects with CHF for age (younger than 65 years and 65 years or older) and submitted them to a short placebo run-in followed by they were then assigned to a 12-month course of therapy with metoprolol or carvedilol. All subjects underwent short time resting recording of RR and then power spectral analysis and calculation of the power law (PL), a measure of heart rate variability. A total 53 subjects completed the study, 32 in the younger group (15 assigned to metoprolol and 17 to carvedilol) and 22 in the older group (10 assigned to metoprolol and 11 to carvedilol). Both treatments significantly increased the PL. In older subjects both treatments induced a similar increase (metoprolol group from -1.61±0.1 to -0.99±0.1, p |
| doi_str_mv | 10.1016/S0895-7061(02)02718-8 |
| format | Article |
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Our aim in this study was to examine the effect of metoprolol and carvedilol on heart rate variability in younger and older subjects with CHF. We subdivided subjects with CHF for age (younger than 65 years and 65 years or older) and submitted them to a short placebo run-in followed by they were then assigned to a 12-month course of therapy with metoprolol or carvedilol. All subjects underwent short time resting recording of RR and then power spectral analysis and calculation of the power law (PL), a measure of heart rate variability. A total 53 subjects completed the study, 32 in the younger group (15 assigned to metoprolol and 17 to carvedilol) and 22 in the older group (10 assigned to metoprolol and 11 to carvedilol). Both treatments significantly increased the PL. In older subjects both treatments induced a similar increase (metoprolol group from -1.61±0.1 to -0.99±0.1, p<0.05; carvedilol group from -1.49±0.1 to -0.94±0.1, p<0.001); in younger subjects carvedilol (from -1.34±0.07 to -0.99±0.04, p<0.05) induced a significantly higher increase (p<0.001) than metoprolol (from -1.37±0.05 to -1.27±0.05, p<0.05). Notably, both beta-blockers significantly increased heart rate variability, the PL increasing by almost 40%. Even though no specific data exist for mortality during treatment with beta-blockers in elderly patients with CHF, our data indicate that these subjects increment heart rate variability, which along with the improvement in other hemodynamic indexes induced us to retain that the treatment with both beta-blockers is advantageous. 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Our aim in this study was to examine the effect of metoprolol and carvedilol on heart rate variability in younger and older subjects with CHF. We subdivided subjects with CHF for age (younger than 65 years and 65 years or older) and submitted them to a short placebo run-in followed by they were then assigned to a 12-month course of therapy with metoprolol or carvedilol. All subjects underwent short time resting recording of RR and then power spectral analysis and calculation of the power law (PL), a measure of heart rate variability. A total 53 subjects completed the study, 32 in the younger group (15 assigned to metoprolol and 17 to carvedilol) and 22 in the older group (10 assigned to metoprolol and 11 to carvedilol). Both treatments significantly increased the PL. 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Our aim in this study was to examine the effect of metoprolol and carvedilol on heart rate variability in younger and older subjects with CHF. We subdivided subjects with CHF for age (younger than 65 years and 65 years or older) and submitted them to a short placebo run-in followed by they were then assigned to a 12-month course of therapy with metoprolol or carvedilol. All subjects underwent short time resting recording of RR and then power spectral analysis and calculation of the power law (PL), a measure of heart rate variability. A total 53 subjects completed the study, 32 in the younger group (15 assigned to metoprolol and 17 to carvedilol) and 22 in the older group (10 assigned to metoprolol and 11 to carvedilol). Both treatments significantly increased the PL. In older subjects both treatments induced a similar increase (metoprolol group from -1.61±0.1 to -0.99±0.1, p<0.05; carvedilol group from -1.49±0.1 to -0.94±0.1, p<0.001); in younger subjects carvedilol (from -1.34±0.07 to -0.99±0.04, p<0.05) induced a significantly higher increase (p<0.001) than metoprolol (from -1.37±0.05 to -1.27±0.05, p<0.05). Notably, both beta-blockers significantly increased heart rate variability, the PL increasing by almost 40%. Even though no specific data exist for mortality during treatment with beta-blockers in elderly patients with CHF, our data indicate that these subjects increment heart rate variability, which along with the improvement in other hemodynamic indexes induced us to retain that the treatment with both beta-blockers is advantageous. 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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Beta-Blocker Chronic Heart Failure Sudden Death |
| title | P-367: Influence of long-term of carvedilol and metoprolol therapy on R-R variability in younger and older adults with chronic heart failure |
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