Regulation of Connexin Expression After Balloon Injury: Possible Mechanisms for Antiproliferative Effect of Statins

Statins, the 3-hydroxy-3-methylglutaryl-cooenzyme A (HMG-CoA) reductase inhibitors, have been shown to inhibit the migration of macrophages and smooth muscle cell proliferation leading to an antiproliferative effect. Although this beneficial effect of statins has been suggested to be independent of...

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Veröffentlicht in:	American journal of hypertension 2005-09, Vol.18 (9), p.1146-1153
Hauptverfasser:	Wang, Lihong, Chen, Junzhu, Sun, Yilan, Zhang, Furong, Zhu, Jianhua, Hu, Shenjiang, Wang, Donna H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive agents Arterial hypertension. Arterial hypotension balloon angioplasty Biological and medical sciences Blood and lymphatic vessels Blotting, Western Body Weight - drug effects Cardiology. Vascular system Cardiovascular system Catheterization - methods Cell Proliferation - drug effects Cholesterol - blood Clinical manifestations. Epidemiology. Investigative techniques. Etiology Connexin 43 - genetics Connexin 43 - metabolism connexins Connexins - genetics Connexins - metabolism Fatty Acids, Monounsaturated - pharmacology Fluvastatin gap junction Gap Junction alpha-5 Protein Gene Expression Regulation - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Iliac Artery - drug effects Iliac Artery - injuries Iliac Artery - metabolism Indoles - pharmacology Lovastatin - pharmacology Male Medical sciences Microscopy, Electron, Transmission Pharmacology. Drug treatments Rabbits Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism statins Tunica Intima - metabolism Tunica Intima - pathology Tunica Intima - ultrastructure Tunica Media - metabolism Tunica Media - pathology Tunica Media - ultrastructure Vascular proliferation
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