P-96: Association of homocysteine levels with salt sensitivity in non-diabetic hypertensives
Hyperhomocysteinemia comprises a well-established independent risk factor for cardiovascular atherosclerotic disease. Although it is a common feature in diabetic hypertensives, the incidence of hyperhomocysteinemia and its correlation with salt sensitivity has not been thoroughly investigated in non...
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| Veröffentlicht in: | American journal of hypertension 2004-05, Vol.17 (S1), p.67A-67A |
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| creator | Aznaouridis, K.A. Vyssoulis, G.P. Karpanou, E.A. Arapogianni, A.N. Chrysohoou, C.A. Zervoudaki, A.I. Cokkinos, D.V. Stefanadis, C.I. |
| description | Hyperhomocysteinemia comprises a well-established independent risk factor for cardiovascular atherosclerotic disease. Although it is a common feature in diabetic hypertensives, the incidence of hyperhomocysteinemia and its correlation with salt sensitivity has not been thoroughly investigated in non-diabetic, essential hypertensive patients (pts). We studied 942 consecutive non-diabetic pts with uncomplicated essential hypertension, after a 2-week wash-out period. Pts with primary hyperhomocysteinemia were excluded. Plasma homocysteine was measured in the same day with 24-hour urine collection for determination of urine sodium concentration (NaC) and total urine sodium excretion (NaT). When classified to quartiles according to plasma homocysteine values, a progressive significant increase mainly for NaC (114.0, 122.5, 126.6 and 141.4 mEq/L, F=22.63, p15 μmol/L, thus considered as suffering from mild hyperhomocysteinemia. Inversely, grouping of pts in NaC quartiles was accompanied by a significant increase in plasma homocysteine levels (11.36, 12.96, 12.40 and 14.57 μmol/L, F=13.65, p |
| doi_str_mv | 10.1016/j.amjhyper.2004.03.170 |
| format | Article |
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Although it is a common feature in diabetic hypertensives, the incidence of hyperhomocysteinemia and its correlation with salt sensitivity has not been thoroughly investigated in non-diabetic, essential hypertensive patients (pts). We studied 942 consecutive non-diabetic pts with uncomplicated essential hypertension, after a 2-week wash-out period. Pts with primary hyperhomocysteinemia were excluded. Plasma homocysteine was measured in the same day with 24-hour urine collection for determination of urine sodium concentration (NaC) and total urine sodium excretion (NaT). When classified to quartiles according to plasma homocysteine values, a progressive significant increase mainly for NaC (114.0, 122.5, 126.6 and 141.4 mEq/L, F=22.63, p<0.001), but also for NaT (199.7, 224.3, 215.7and 233.0 mEq/24h, F=3.96, p=0.02) was observed. It is noteworthy that pts of the uppermost quartile had a mean homocysteine value >15 μmol/L, thus considered as suffering from mild hyperhomocysteinemia. Inversely, grouping of pts in NaC quartiles was accompanied by a significant increase in plasma homocysteine levels (11.36, 12.96, 12.40 and 14.57 μmol/L, F=13.65, p<0.00001). Overall, homocysteine levels correlated with NaC (r=0.252, p<0.00001). In conclusion, increased dietary salt ingestion as expressed by 24-h urine Na measurements, is associated with higher plasma homocysteine levels in non-diabetic hypertensives. Am J Hypertens (2004) 17, 67A–67A; doi: 10.1016/j.amjhyper.2004.03.170</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2004.03.170</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Homocysteine ; Hyperhomocysteinemia ; Salt Sensitivity</subject><ispartof>American journal of hypertension, 2004-05, Vol.17 (S1), p.67A-67A</ispartof><rights>Copyright Nature Publishing Group May 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Aznaouridis, K.A.</creatorcontrib><creatorcontrib>Vyssoulis, G.P.</creatorcontrib><creatorcontrib>Karpanou, E.A.</creatorcontrib><creatorcontrib>Arapogianni, A.N.</creatorcontrib><creatorcontrib>Chrysohoou, C.A.</creatorcontrib><creatorcontrib>Zervoudaki, A.I.</creatorcontrib><creatorcontrib>Cokkinos, D.V.</creatorcontrib><creatorcontrib>Stefanadis, C.I.</creatorcontrib><title>P-96: Association of homocysteine levels with salt sensitivity in non-diabetic hypertensives</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Hyperhomocysteinemia comprises a well-established independent risk factor for cardiovascular atherosclerotic disease. Although it is a common feature in diabetic hypertensives, the incidence of hyperhomocysteinemia and its correlation with salt sensitivity has not been thoroughly investigated in non-diabetic, essential hypertensive patients (pts). We studied 942 consecutive non-diabetic pts with uncomplicated essential hypertension, after a 2-week wash-out period. Pts with primary hyperhomocysteinemia were excluded. Plasma homocysteine was measured in the same day with 24-hour urine collection for determination of urine sodium concentration (NaC) and total urine sodium excretion (NaT). When classified to quartiles according to plasma homocysteine values, a progressive significant increase mainly for NaC (114.0, 122.5, 126.6 and 141.4 mEq/L, F=22.63, p<0.001), but also for NaT (199.7, 224.3, 215.7and 233.0 mEq/24h, F=3.96, p=0.02) was observed. It is noteworthy that pts of the uppermost quartile had a mean homocysteine value >15 μmol/L, thus considered as suffering from mild hyperhomocysteinemia. Inversely, grouping of pts in NaC quartiles was accompanied by a significant increase in plasma homocysteine levels (11.36, 12.96, 12.40 and 14.57 μmol/L, F=13.65, p<0.00001). Overall, homocysteine levels correlated with NaC (r=0.252, p<0.00001). In conclusion, increased dietary salt ingestion as expressed by 24-h urine Na measurements, is associated with higher plasma homocysteine levels in non-diabetic hypertensives. Am J Hypertens (2004) 17, 67A–67A; doi: 10.1016/j.amjhyper.2004.03.170</description><subject>Homocysteine</subject><subject>Hyperhomocysteinemia</subject><subject>Salt Sensitivity</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNotz1FLwzAUBeAgCs7pX5CAz6lJk9yuvo1NnTjQhz0MEUrW3LDUrZ1NNu2_tzqf7svHOecSci14IriA2yox22rd7bBNUs5VwmUiMn5CBiJXgmVpqk_JgI9yzTIO4pxchFDxHgKIAXl_ZTnc0XEITelN9E1NG0fXzbYpuxDR10g3eMBNoF8-rmkwm0gD1sFHf_Cxo76mdVMz680Koy_p3474Cw4YLsmZM5uAV_93SBYP94vJjM1fHp8m4znzAJppWFksJXc2d46XaAABpLWIygIYrVbSlRacGGmVOkDMtZR5qVTKrVN5Jofk5hi7a5vPPYZYVM2-rfvGQvAUtBIi1b1iR-X7v76LXeu3pu0K034UkMlMF7PlWzHRo-fpcqoKKX8A3XtoWw</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Aznaouridis, K.A.</creator><creator>Vyssoulis, G.P.</creator><creator>Karpanou, E.A.</creator><creator>Arapogianni, A.N.</creator><creator>Chrysohoou, C.A.</creator><creator>Zervoudaki, A.I.</creator><creator>Cokkinos, D.V.</creator><creator>Stefanadis, C.I.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200405</creationdate><title>P-96: Association of homocysteine levels with salt sensitivity in non-diabetic hypertensives</title><author>Aznaouridis, K.A. ; Vyssoulis, G.P. ; Karpanou, E.A. ; Arapogianni, A.N. ; Chrysohoou, C.A. ; Zervoudaki, A.I. ; Cokkinos, D.V. ; Stefanadis, C.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i665-56bdec30fd9ff0cea6e663ddee4d66a54b3fcd6f18542f6ee95339c4420df4973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Homocysteine</topic><topic>Hyperhomocysteinemia</topic><topic>Salt Sensitivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aznaouridis, K.A.</creatorcontrib><creatorcontrib>Vyssoulis, G.P.</creatorcontrib><creatorcontrib>Karpanou, E.A.</creatorcontrib><creatorcontrib>Arapogianni, A.N.</creatorcontrib><creatorcontrib>Chrysohoou, C.A.</creatorcontrib><creatorcontrib>Zervoudaki, A.I.</creatorcontrib><creatorcontrib>Cokkinos, D.V.</creatorcontrib><creatorcontrib>Stefanadis, C.I.</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aznaouridis, K.A.</au><au>Vyssoulis, G.P.</au><au>Karpanou, E.A.</au><au>Arapogianni, A.N.</au><au>Chrysohoou, C.A.</au><au>Zervoudaki, A.I.</au><au>Cokkinos, D.V.</au><au>Stefanadis, C.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-96: Association of homocysteine levels with salt sensitivity in non-diabetic hypertensives</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2004-05</date><risdate>2004</risdate><volume>17</volume><issue>S1</issue><spage>67A</spage><epage>67A</epage><pages>67A-67A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>Hyperhomocysteinemia comprises a well-established independent risk factor for cardiovascular atherosclerotic disease. Although it is a common feature in diabetic hypertensives, the incidence of hyperhomocysteinemia and its correlation with salt sensitivity has not been thoroughly investigated in non-diabetic, essential hypertensive patients (pts). We studied 942 consecutive non-diabetic pts with uncomplicated essential hypertension, after a 2-week wash-out period. Pts with primary hyperhomocysteinemia were excluded. Plasma homocysteine was measured in the same day with 24-hour urine collection for determination of urine sodium concentration (NaC) and total urine sodium excretion (NaT). When classified to quartiles according to plasma homocysteine values, a progressive significant increase mainly for NaC (114.0, 122.5, 126.6 and 141.4 mEq/L, F=22.63, p<0.001), but also for NaT (199.7, 224.3, 215.7and 233.0 mEq/24h, F=3.96, p=0.02) was observed. It is noteworthy that pts of the uppermost quartile had a mean homocysteine value >15 μmol/L, thus considered as suffering from mild hyperhomocysteinemia. Inversely, grouping of pts in NaC quartiles was accompanied by a significant increase in plasma homocysteine levels (11.36, 12.96, 12.40 and 14.57 μmol/L, F=13.65, p<0.00001). Overall, homocysteine levels correlated with NaC (r=0.252, p<0.00001). In conclusion, increased dietary salt ingestion as expressed by 24-h urine Na measurements, is associated with higher plasma homocysteine levels in non-diabetic hypertensives. Am J Hypertens (2004) 17, 67A–67A; doi: 10.1016/j.amjhyper.2004.03.170</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/j.amjhyper.2004.03.170</doi></addata></record> |
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| subjects | Homocysteine Hyperhomocysteinemia Salt Sensitivity |
| title | P-96: Association of homocysteine levels with salt sensitivity in non-diabetic hypertensives |
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