OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension
The effect of centrally or peripherally acting antihypertensive agents on cardiac autonomic balance has not been evaluated. Assessment of heart rate variability (HRV) is a useful non-invasive way to evaluate cardiac autonomic balance. The aim of this study was to compare the effect of a central symp...
Gespeichert in:
| Veröffentlicht in: | American journal of hypertension 2004-05, Vol.17 (S1), p.14A-14A |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14A |
|---|---|
| container_issue | S1 |
| container_start_page | 14A |
| container_title | American journal of hypertension |
| container_volume | 17 |
| creator | Nicopoulos, Christos Fountoulaki, Aikaterini Giannakoulis, John Demopoulos, Vasilis Skoularigis, John Triposkiadis, Fillipos |
| description | The effect of centrally or peripherally acting antihypertensive agents on cardiac autonomic balance has not been evaluated. Assessment of heart rate variability (HRV) is a useful non-invasive way to evaluate cardiac autonomic balance. The aim of this study was to compare the effect of a central sympathetic inhibitor (moxonidine) against that of a peripheral inhibitor (nebivolol - a b1-blocker), on arterial blood pressure (BP) and HRV in patients with mild to moderate essential hypertension. Twenty-seven patients were randomized to receive either moxonidine 0.4–0.6 mg once daily (7 men and 5 women, mean age 50±6 years) or nebivolol 2.5–5 mg once daily (9 men and 6 women, mean age 53±6 years) for one month, to achieve a target diastolic BP |
| doi_str_mv | 10.1016/j.amjhyper.2004.03.030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_istex</sourceid><recordid>TN_cdi_proquest_journals_1026537626</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2712429701</sourcerecordid><originalsourceid>FETCH-LOGICAL-i666-8270a0e0ca7dc6224934e3ea92d9edc69851a3b9eabaffc3b9750a36cbb719053</originalsourceid><addsrcrecordid>eNotjt1Kw0AQhRdRsFZfQRa8Tt2fZLfxztafioWC9KJ4EybJlGxsk7i7KeYJfG23KgzMcOabc4aQa84mnHF1W09gX1dDh3YiGIsnTIZiJ2TE05hHWojklIzYNE0izRQ_JxfO1SyASvER-V69Ucnv6Bwbb2FHD2hd72gwM12FR8UN-w58hd4U1DSVyY03bUNDgfUBC0i-a9uSdhad6y1SaEpaYdhSCx7pAQKUm53xQzCgAQpZx7Pfnz02LvhdkrMt7Bxe_fcxWT89rueLaLl6fpnfLyOjlIqmQjNgyArQZaGEiFMZo0RIRZliUNJpwkHmKUIO220RJp0wkKrIc81Tlsgxufmz7Wz72aPzWd32tgmJGWdCJVIroQIV_VHGefzKOmv2YIcM7EemtNRJtti8Zw9qEyez2Ws2lz9EPnhO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1026537626</pqid></control><display><type>article</type><title>OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension</title><source>Oxford University Press Journals Current</source><creator>Nicopoulos, Christos ; Fountoulaki, Aikaterini ; Giannakoulis, John ; Demopoulos, Vasilis ; Skoularigis, John ; Triposkiadis, Fillipos</creator><creatorcontrib>Nicopoulos, Christos ; Fountoulaki, Aikaterini ; Giannakoulis, John ; Demopoulos, Vasilis ; Skoularigis, John ; Triposkiadis, Fillipos</creatorcontrib><description><![CDATA[The effect of centrally or peripherally acting antihypertensive agents on cardiac autonomic balance has not been evaluated. Assessment of heart rate variability (HRV) is a useful non-invasive way to evaluate cardiac autonomic balance. The aim of this study was to compare the effect of a central sympathetic inhibitor (moxonidine) against that of a peripheral inhibitor (nebivolol - a b1-blocker), on arterial blood pressure (BP) and HRV in patients with mild to moderate essential hypertension. Twenty-seven patients were randomized to receive either moxonidine 0.4–0.6 mg once daily (7 men and 5 women, mean age 50±6 years) or nebivolol 2.5–5 mg once daily (9 men and 6 women, mean age 53±6 years) for one month, to achieve a target diastolic BP <90 mmHg. BP was measured with sphygmomanometry and HRV parameters, in the time and frequency domain, were estimated from 24-hour Holter recordings. Two independent investigators blinded to treatment assignment performed data analysis. Results are summarized in the Table: DBP=diastolic BP, HR=heart rate, M=morning hours (07:00–13:00), N=night hours (24:00–07:00), SBP=systolic BP. Moxonidine (n = 12) Nebivolol (n = 15) Baseline Follow-up P-value Baseline Follow-up P-value SBP (mmHg) 156 ± 7 129 ± 10 <0.01 155 ± 10 130 ± 10 <0.01 DBP (mmHg) 97 ± 3 83 ± 4 <0.01 99 ± 6 84 ± 5 <0.01 HR (b/m) 81 ± 6 82 ± 9 NS 74 ± 5 65 ± 8 <0.01 Log HF M 2.05 ± 0.32 2.22 ± 0.28 NS 2.16 ± 0.27 2.45 ± 0.47 <0.05 Log HF N 2 ± 0.3 2.29 ± 0.33 <0.05 2.32 ± 0.34 2.5 ± 0.37 NS Log LF/HF M 0.64 ± 0.19 0.5 ± 0.23 NS 0.57 ± 0.26 0.4 ± 0.18 NS Log LF/HF N 0.65 ± 0.1 0.4 ± 0.22 <0.05 0.48 ± 0.29 0.4 ± 0.28 NS In conclusion, both agents significantly reduced arterial BP to the same extent. However, moxonidine had a favorable effect on cardiac autonomic balance during night hours, whereas nebivolol during morning hours. Thus, the effect of antihypertensive agents on cardiac autonomic balance differs greatly and the clinical significance of it needs further investigation.]]></description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2004.03.030</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antihypertensive Treatment ; Heart Rate Variability ; Sympathetic Inhibition</subject><ispartof>American journal of hypertension, 2004-05, Vol.17 (S1), p.14A-14A</ispartof><rights>Copyright Nature Publishing Group May 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Nicopoulos, Christos</creatorcontrib><creatorcontrib>Fountoulaki, Aikaterini</creatorcontrib><creatorcontrib>Giannakoulis, John</creatorcontrib><creatorcontrib>Demopoulos, Vasilis</creatorcontrib><creatorcontrib>Skoularigis, John</creatorcontrib><creatorcontrib>Triposkiadis, Fillipos</creatorcontrib><title>OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description><![CDATA[The effect of centrally or peripherally acting antihypertensive agents on cardiac autonomic balance has not been evaluated. Assessment of heart rate variability (HRV) is a useful non-invasive way to evaluate cardiac autonomic balance. The aim of this study was to compare the effect of a central sympathetic inhibitor (moxonidine) against that of a peripheral inhibitor (nebivolol - a b1-blocker), on arterial blood pressure (BP) and HRV in patients with mild to moderate essential hypertension. Twenty-seven patients were randomized to receive either moxonidine 0.4–0.6 mg once daily (7 men and 5 women, mean age 50±6 years) or nebivolol 2.5–5 mg once daily (9 men and 6 women, mean age 53±6 years) for one month, to achieve a target diastolic BP <90 mmHg. BP was measured with sphygmomanometry and HRV parameters, in the time and frequency domain, were estimated from 24-hour Holter recordings. Two independent investigators blinded to treatment assignment performed data analysis. Results are summarized in the Table: DBP=diastolic BP, HR=heart rate, M=morning hours (07:00–13:00), N=night hours (24:00–07:00), SBP=systolic BP. Moxonidine (n = 12) Nebivolol (n = 15) Baseline Follow-up P-value Baseline Follow-up P-value SBP (mmHg) 156 ± 7 129 ± 10 <0.01 155 ± 10 130 ± 10 <0.01 DBP (mmHg) 97 ± 3 83 ± 4 <0.01 99 ± 6 84 ± 5 <0.01 HR (b/m) 81 ± 6 82 ± 9 NS 74 ± 5 65 ± 8 <0.01 Log HF M 2.05 ± 0.32 2.22 ± 0.28 NS 2.16 ± 0.27 2.45 ± 0.47 <0.05 Log HF N 2 ± 0.3 2.29 ± 0.33 <0.05 2.32 ± 0.34 2.5 ± 0.37 NS Log LF/HF M 0.64 ± 0.19 0.5 ± 0.23 NS 0.57 ± 0.26 0.4 ± 0.18 NS Log LF/HF N 0.65 ± 0.1 0.4 ± 0.22 <0.05 0.48 ± 0.29 0.4 ± 0.28 NS In conclusion, both agents significantly reduced arterial BP to the same extent. However, moxonidine had a favorable effect on cardiac autonomic balance during night hours, whereas nebivolol during morning hours. Thus, the effect of antihypertensive agents on cardiac autonomic balance differs greatly and the clinical significance of it needs further investigation.]]></description><subject>Antihypertensive Treatment</subject><subject>Heart Rate Variability</subject><subject>Sympathetic Inhibition</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNotjt1Kw0AQhRdRsFZfQRa8Tt2fZLfxztafioWC9KJ4EybJlGxsk7i7KeYJfG23KgzMcOabc4aQa84mnHF1W09gX1dDh3YiGIsnTIZiJ2TE05hHWojklIzYNE0izRQ_JxfO1SyASvER-V69Ucnv6Bwbb2FHD2hd72gwM12FR8UN-w58hd4U1DSVyY03bUNDgfUBC0i-a9uSdhad6y1SaEpaYdhSCx7pAQKUm53xQzCgAQpZx7Pfnz02LvhdkrMt7Bxe_fcxWT89rueLaLl6fpnfLyOjlIqmQjNgyArQZaGEiFMZo0RIRZliUNJpwkHmKUIO220RJp0wkKrIc81Tlsgxufmz7Wz72aPzWd32tgmJGWdCJVIroQIV_VHGefzKOmv2YIcM7EemtNRJtti8Zw9qEyez2Ws2lz9EPnhO</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Nicopoulos, Christos</creator><creator>Fountoulaki, Aikaterini</creator><creator>Giannakoulis, John</creator><creator>Demopoulos, Vasilis</creator><creator>Skoularigis, John</creator><creator>Triposkiadis, Fillipos</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200405</creationdate><title>OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension</title><author>Nicopoulos, Christos ; Fountoulaki, Aikaterini ; Giannakoulis, John ; Demopoulos, Vasilis ; Skoularigis, John ; Triposkiadis, Fillipos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i666-8270a0e0ca7dc6224934e3ea92d9edc69851a3b9eabaffc3b9750a36cbb719053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antihypertensive Treatment</topic><topic>Heart Rate Variability</topic><topic>Sympathetic Inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicopoulos, Christos</creatorcontrib><creatorcontrib>Fountoulaki, Aikaterini</creatorcontrib><creatorcontrib>Giannakoulis, John</creatorcontrib><creatorcontrib>Demopoulos, Vasilis</creatorcontrib><creatorcontrib>Skoularigis, John</creatorcontrib><creatorcontrib>Triposkiadis, Fillipos</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicopoulos, Christos</au><au>Fountoulaki, Aikaterini</au><au>Giannakoulis, John</au><au>Demopoulos, Vasilis</au><au>Skoularigis, John</au><au>Triposkiadis, Fillipos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2004-05</date><risdate>2004</risdate><volume>17</volume><issue>S1</issue><spage>14A</spage><epage>14A</epage><pages>14A-14A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract><![CDATA[The effect of centrally or peripherally acting antihypertensive agents on cardiac autonomic balance has not been evaluated. Assessment of heart rate variability (HRV) is a useful non-invasive way to evaluate cardiac autonomic balance. The aim of this study was to compare the effect of a central sympathetic inhibitor (moxonidine) against that of a peripheral inhibitor (nebivolol - a b1-blocker), on arterial blood pressure (BP) and HRV in patients with mild to moderate essential hypertension. Twenty-seven patients were randomized to receive either moxonidine 0.4–0.6 mg once daily (7 men and 5 women, mean age 50±6 years) or nebivolol 2.5–5 mg once daily (9 men and 6 women, mean age 53±6 years) for one month, to achieve a target diastolic BP <90 mmHg. BP was measured with sphygmomanometry and HRV parameters, in the time and frequency domain, were estimated from 24-hour Holter recordings. Two independent investigators blinded to treatment assignment performed data analysis. Results are summarized in the Table: DBP=diastolic BP, HR=heart rate, M=morning hours (07:00–13:00), N=night hours (24:00–07:00), SBP=systolic BP. Moxonidine (n = 12) Nebivolol (n = 15) Baseline Follow-up P-value Baseline Follow-up P-value SBP (mmHg) 156 ± 7 129 ± 10 <0.01 155 ± 10 130 ± 10 <0.01 DBP (mmHg) 97 ± 3 83 ± 4 <0.01 99 ± 6 84 ± 5 <0.01 HR (b/m) 81 ± 6 82 ± 9 NS 74 ± 5 65 ± 8 <0.01 Log HF M 2.05 ± 0.32 2.22 ± 0.28 NS 2.16 ± 0.27 2.45 ± 0.47 <0.05 Log HF N 2 ± 0.3 2.29 ± 0.33 <0.05 2.32 ± 0.34 2.5 ± 0.37 NS Log LF/HF M 0.64 ± 0.19 0.5 ± 0.23 NS 0.57 ± 0.26 0.4 ± 0.18 NS Log LF/HF N 0.65 ± 0.1 0.4 ± 0.22 <0.05 0.48 ± 0.29 0.4 ± 0.28 NS In conclusion, both agents significantly reduced arterial BP to the same extent. However, moxonidine had a favorable effect on cardiac autonomic balance during night hours, whereas nebivolol during morning hours. Thus, the effect of antihypertensive agents on cardiac autonomic balance differs greatly and the clinical significance of it needs further investigation.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/j.amjhyper.2004.03.030</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2004-05, Vol.17 (S1), p.14A-14A |
| issn | 0895-7061 1941-7225 |
| language | eng |
| recordid | cdi_proquest_journals_1026537626 |
| source | Oxford University Press Journals Current |
| subjects | Antihypertensive Treatment Heart Rate Variability Sympathetic Inhibition |
| title | OR 31: Central versus peripheral sympathetic inhibition on arterial blood pressure and heart rate variability in essential hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T13%3A14%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_istex&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=OR%2031:%20Central%20versus%20peripheral%20sympathetic%20inhibition%20on%20arterial%20blood%20pressure%20and%20heart%20rate%20variability%20in%20essential%20hypertension&rft.jtitle=American%20journal%20of%20hypertension&rft.au=Nicopoulos,%20Christos&rft.date=2004-05&rft.volume=17&rft.issue=S1&rft.spage=14A&rft.epage=14A&rft.pages=14A-14A&rft.issn=0895-7061&rft.eissn=1941-7225&rft.coden=AJHYE6&rft_id=info:doi/10.1016/j.amjhyper.2004.03.030&rft_dat=%3Cproquest_istex%3E2712429701%3C/proquest_istex%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1026537626&rft_id=info:pmid/&rfr_iscdi=true |