In vivo role of focal adhesion kinase in regulating pancreatic [beta]-cell mass and function through insulin signaling, actin dynamics, and granule trafficking

Focal adhesion kinase (FAK) acts as an adaptor at the focal contacts serving as a junction between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a determinant step in insulin secretion. Additionally, FAK has been shown to regulate insulin signaling. To investigate the e...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-07, Vol.61 (7), p.1708
Hauptverfasser:	Cai, Erica P, Casimir, Marina, Schroer, Stephanie A, Luk, Cynthia T, Shi, Sally Yu, Choi, Diana, Dai, Xiao Qing, Hajmrle, Catherine, Spigelman, Aliya F, Zhu, Dan, Gaisano, Herbert Y, MacDonald, Patrick E, Woo, Minna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Analysis Apoptosis Cyclin-dependent kinases Extracellular matrix Glucagon Glucose Homeostasis Insulin resistance Kinases Microscopy Pancreas Pancreatic beta cells Phosphorylation Physiological aspects Protein tyrosine kinase Proteins
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