GSTP1 and CYP1A1 Gene Polymorphisms and Non-Hodgkin Lymphoma

To determine the association between genetic variants of GSTP1 and CYP1A1 enzymes and individual susceptibility to diffuse large B-cell lymphoma (DLBCL), as well as correlations with tobacco smoking. Fifty patients with DLBCL and 50 apparently healthy volunteers were genotyped for detection of GSTP1 and CYP1A1 polymorphisms by the restriction fragment length polymorphism (RFLP) technique. For GSTP1 313 A[arrow right]G polymorphism, statistically significant differences were observed between the DLBCL and control groups for the AA, AG, and GG genotypes, as well as the G allele. For CYP1A1 4889 A[arrow right]G (M2) polymorphism, statistically significant differences were observed for the AA and AG genotypes and the G allele. The relationship of smoking status to susceptibility to DLBCL in the presence of these genetic polymorphisms revealed that smoking status had no effect. GSTP1 313 A[arrow right]G polymorphism is associated with a decreased risk of lymphoma, whereas CYP1A1 4889 A[arrow right]G (M2) polymorphism is associated with an increased risk of lymphoma regardless of smoking status.