Toxicity in Chemotherapy — When Less Is More
Normal cells and cancer cells respond differently to fasting: normal cells switch to maintenance pathways, but cancer cells do not and are thus sensitized to oxidative stress. A recent study suggests that fasting also renders cancer cells more susceptible to chemotherapy. Food is a potent inducer of...
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| Veröffentlicht in: | The New England journal of medicine 2012-06, Vol.366 (24), p.2319-2320 |
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| container_title | The New England journal of medicine |
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| creator | Laviano, Alessandro Rossi Fanelli, Filippo |
| description | Normal cells and cancer cells respond differently to fasting: normal cells switch to maintenance pathways, but cancer cells do not and are thus sensitized to oxidative stress. A recent study suggests that fasting also renders cancer cells more susceptible to chemotherapy.
Food is a potent inducer of metabolic responses. Specific nutrients enhance muscle accretion, while others modulate the inflammatory response or boost appetite. On the other hand, caloric restriction under normal conditions (i.e., the prolonged intake of approximately 20 to 40% fewer calories than are required) has been shown to protect against the development of chronic diseases.
1
Exploiting the differential effects of food and its absence on metabolic pathways during disease may be one strategy to enhance the efficacy of drug therapies.
Significant improvements in the field of oncology have enhanced prevention, screening, early diagnosis, and treatment. Nevertheless, the prevalence of . . . |
| doi_str_mv | 10.1056/NEJMcibr1202395 |
| format | Article |
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Food is a potent inducer of metabolic responses. Specific nutrients enhance muscle accretion, while others modulate the inflammatory response or boost appetite. On the other hand, caloric restriction under normal conditions (i.e., the prolonged intake of approximately 20 to 40% fewer calories than are required) has been shown to protect against the development of chronic diseases.
1
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Food is a potent inducer of metabolic responses. Specific nutrients enhance muscle accretion, while others modulate the inflammatory response or boost appetite. On the other hand, caloric restriction under normal conditions (i.e., the prolonged intake of approximately 20 to 40% fewer calories than are required) has been shown to protect against the development of chronic diseases.
1
Exploiting the differential effects of food and its absence on metabolic pathways during disease may be one strategy to enhance the efficacy of drug therapies.
Significant improvements in the field of oncology have enhanced prevention, screening, early diagnosis, and treatment. 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A recent study suggests that fasting also renders cancer cells more susceptible to chemotherapy.
Food is a potent inducer of metabolic responses. Specific nutrients enhance muscle accretion, while others modulate the inflammatory response or boost appetite. On the other hand, caloric restriction under normal conditions (i.e., the prolonged intake of approximately 20 to 40% fewer calories than are required) has been shown to protect against the development of chronic diseases.
1
Exploiting the differential effects of food and its absence on metabolic pathways during disease may be one strategy to enhance the efficacy of drug therapies.
Significant improvements in the field of oncology have enhanced prevention, screening, early diagnosis, and treatment. Nevertheless, the prevalence of . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>22694004</pmid><doi>10.1056/NEJMcibr1202395</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Cancer Cancer therapies Chemotherapy Combined Modality Therapy Fasting Humans Mice Mortality Neoplasms - diet therapy Neoplasms - drug therapy Oxidative stress Toxicity |
| title | Toxicity in Chemotherapy — When Less Is More |
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