Targeting mitochondria by [alpha]-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression

Amplification of the MycN oncogene characterizes a subset of highly aggressive neuroblastomas, the most common extracranial solid tumor of childhood. However, the significance of MycN amplification for tumor cell survival is controversial, since down-regulation of MycN was found to decrease markedly...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2012-06, Vol.69 (12), p.2091
Hauptverfasser:	Kruspig, Björn, Nilchian, Azadeh, Bejarano, Ignacio, Orrenius, Sten, Zhivotovsky, Boris, Gogvadze, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Chelation Gene expression Mitochondria Oncology Tumors
Online-Zugang:	Volltext
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