Model for MLL translocations in therapy-related leukemia involving topoisomerase II[Beta]-mediated DNA strand breaks and gene proximity

Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective cytotoxic anticancer agents. However, they are associated with the development of therapy-related acute myeloid leukemias (t-AMLs), which display characteristic balanced chromosome translocations, most often inv...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-06, Vol.109 (23), p.8989
Hauptverfasser:	Cowell, Ian G, Sondka, Zbyslaw, Smith, Kayleigh, Lee, Ka Cheong, Manville, Catriona M, Sidorczuk-Lesthuruge, Malgorzata, Rance, Holly Ashlene, Padget, Kay, Jackson, Graham Hunter, Adachi, Noritaka, Austin, Caroline A
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes Deoxyribonucleic acid DNA Genes Toxicity
Online-Zugang:	Volltext
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