Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

BMP7 has been previously shown to protect against renal fibrosis. Raghu Kalluri and his colleagues have now identified activin-like kinase 3 (Alk3) as the key co-receptor for BMP7 in the kidney and have identified an orally available, small-peptide agonist of Alk3 that reduces established fibrosis i...

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Veröffentlicht in:	Nature medicine 2012-03, Vol.18 (3), p.396-404
Hauptverfasser:	Sugimoto, Hikaru, LeBleu, Valerie S, Bosukonda, Dattatreyamurty, Keck, Peter, Taduri, Gangadhar, Bechtel, Wibke, Okada, Hirokazu, Carlson, William, Bey, Philippe, Rusckowski, Mary, Tampe, Björn, Tampe, Desiree, Kanasaki, Keizo, Zeisberg, Michael, Kalluri, Raghu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/86 692/308/153 692/699/1585 692/700/565 Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Apoptosis - genetics Biomedical and Life Sciences Biomedicine Bone Morphogenetic Protein Receptors - genetics Bone Morphogenetic Protein Receptors - metabolism Bone Morphogenetic Protein Receptors, Type I - genetics Bone Morphogenetic Protein Receptors, Type I - metabolism Bone Morphogenetic Protein Receptors, Type II - genetics Bone Morphogenetic Protein Receptors, Type II - metabolism Bone Morphogenetic Proteins - agonists Bone Morphogenetic Proteins - metabolism Cancer Research Captopril - pharmacology Cellular signal transduction Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Enzyme inhibitors Epithelial-Mesenchymal Transition Fibrosis - metabolism Gene expression Infectious Diseases Inflammation - genetics Inflammation - metabolism Kidney - injuries Kidney - metabolism Kidney diseases Kidney Tubules - metabolism Kidneys Kinases Metabolic Diseases Mice Molecular Medicine Neurosciences Peptide Library Peptides - chemical synthesis Peptides - metabolism Peptides - pharmacokinetics Pharmacology Physiological aspects Protein kinases Rats Rats, Sprague-Dawley Regeneration - genetics Risk factors Rodents Signal Transduction Smad3 Protein - genetics Smad3 Protein - metabolism Structure-Activity Relationship Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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