The effect of berberine administration to rats on the functional state of liver after common bile duct ligation
On day 8 after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol, bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the hepatic microsomal fraction there was a marked decrease in the content and act...
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| Veröffentlicht in: | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2012-04, Vol.6 (2), p.159-163 |
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| container_title | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry |
| container_volume | 6 |
| creator | Zverinsky, I. V. Melnichenko, N. G. Poplavsky, V. A. Sutsko, I. P. Telegin, P. G. Shlyahtun, A. G. |
| description | On day 8 after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol, bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the hepatic microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injections of berberine (10 mg/kg) for 6 days caused a partial normalization of hepatocyte plasma permeability and activity of microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. The membrane-stabilizing effect of berberine is probably realized at the level of inhibition of the prooxidant status of liver cells. |
| doi_str_mv | 10.1134/S1990750812020163 |
| format | Article |
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Introperitoneal injections of berberine (10 mg/kg) for 6 days caused a partial normalization of hepatocyte plasma permeability and activity of microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. 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| ispartof | Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry, 2012-04, Vol.6 (2), p.159-163 |
| issn | 1990-7508 1990-7516 |
| language | eng |
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| source | Springer Online Journals Complete |
| subjects | Bile Biochemistry Bioorganic Chemistry Chemistry Chemistry and Materials Science Enzymes Lipids Liver Medical disorders Medicinal Chemistry Rodents |
| title | The effect of berberine administration to rats on the functional state of liver after common bile duct ligation |
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