Oral field cancerization: current evidence and future perspectives
Introduction Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen...
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| Veröffentlicht in: | Oral and maxillofacial surgery 2012-06, Vol.16 (2), p.171-180 |
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| creator | Angadi, Punnya V. Savitha, J. K. Rao, Sanjay S. Sivaranjini, Y. |
| description | Introduction
Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.
Discussion
This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed. |
| doi_str_mv | 10.1007/s10006-012-0317-x |
| format | Article |
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Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.
Discussion
This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed.</description><identifier>ISSN: 1865-1550</identifier><identifier>EISSN: 1865-1569</identifier><identifier>DOI: 10.1007/s10006-012-0317-x</identifier><identifier>PMID: 22354325</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Alcohol Drinking - adverse effects ; Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Carcinoma, Verrucous - genetics ; Carcinoma, Verrucous - pathology ; Carcinoma, Verrucous - surgery ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Clone Cells - pathology ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; Leukoplakia, Oral - genetics ; Leukoplakia, Oral - pathology ; Leukoplakia, Oral - surgery ; Lip Neoplasms - genetics ; Lip Neoplasms - pathology ; Lip Neoplasms - surgery ; Medicine ; Medicine & Public Health ; Mouth Mucosa - pathology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neoplasms, Multiple Primary - genetics ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - surgery ; Oral and Maxillofacial Surgery ; Precancerous Conditions - genetics ; Precancerous Conditions - pathology ; Precancerous Conditions - surgery ; Prognosis ; Review Article ; Risk Factors ; Smoking - adverse effects</subject><ispartof>Oral and maxillofacial surgery, 2012-06, Vol.16 (2), p.171-180</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-743377fe97b9cf8b0a15e2ad65ff2c2463aa0695523a6f74a7eedb981eb39213</citedby><cites>FETCH-LOGICAL-c438t-743377fe97b9cf8b0a15e2ad65ff2c2463aa0695523a6f74a7eedb981eb39213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10006-012-0317-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10006-012-0317-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22354325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Angadi, Punnya V.</creatorcontrib><creatorcontrib>Savitha, J. K.</creatorcontrib><creatorcontrib>Rao, Sanjay S.</creatorcontrib><creatorcontrib>Sivaranjini, Y.</creatorcontrib><title>Oral field cancerization: current evidence and future perspectives</title><title>Oral and maxillofacial surgery</title><addtitle>Oral Maxillofac Surg</addtitle><addtitle>Oral Maxillofac Surg</addtitle><description>Introduction
Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.
Discussion
This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed.</description><subject>Alcohol Drinking - adverse effects</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carcinoma, Verrucous - genetics</subject><subject>Carcinoma, Verrucous - pathology</subject><subject>Carcinoma, Verrucous - surgery</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Clone Cells - pathology</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Leukoplakia, Oral - genetics</subject><subject>Leukoplakia, Oral - pathology</subject><subject>Leukoplakia, Oral - surgery</subject><subject>Lip Neoplasms - genetics</subject><subject>Lip Neoplasms - pathology</subject><subject>Lip Neoplasms - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasms, Multiple Primary - genetics</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - pathology</subject><subject>Precancerous Conditions - surgery</subject><subject>Prognosis</subject><subject>Review Article</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><issn>1865-1550</issn><issn>1865-1569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC8S8Ly6H9ndxJsWv6DQS-_LZjMrKWkSd5NS_fVuSS1evMwMzDPvwIPQNSV3lBB1H2IlEhPKMOFU4d0JmtJMCkyFzE-PsyATdBHCOrKMCnKOJoxxkXImpuhp6U2duArqMrGmseCrb9NXbfOQ2MF7aPoEtlUJcZOYpkzc0A8ekg586MD21RbCJTpzpg5wdegztHp5Xs3f8GL5-j5_XGCb8qzHKuVcKQe5KnLrsoIYKoCZUgrnmGWp5MYQmQvBuJFOpUYBlEWeUSh4ziifodsxtvPt5wCh1-t28E38qCmhSlIusyxSdKSsb0Pw4HTnq43xXxHSe2l6lKajNL2Xpnfx5uaQPBQbKI8Xv5YiwEYgxFXzAf7v6_9SfwB8Dnd3</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Angadi, Punnya V.</creator><creator>Savitha, J. 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K.</au><au>Rao, Sanjay S.</au><au>Sivaranjini, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral field cancerization: current evidence and future perspectives</atitle><jtitle>Oral and maxillofacial surgery</jtitle><stitle>Oral Maxillofac Surg</stitle><addtitle>Oral Maxillofac Surg</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>16</volume><issue>2</issue><spage>171</spage><epage>180</epage><pages>171-180</pages><issn>1865-1550</issn><eissn>1865-1569</eissn><abstract>Introduction
Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.
Discussion
This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22354325</pmid><doi>10.1007/s10006-012-0317-x</doi><tpages>10</tpages></addata></record> |
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| subjects | Alcohol Drinking - adverse effects Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Carcinoma, Verrucous - genetics Carcinoma, Verrucous - pathology Carcinoma, Verrucous - surgery Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Clone Cells - pathology Gene Expression Regulation, Neoplastic - genetics Humans Leukoplakia, Oral - genetics Leukoplakia, Oral - pathology Leukoplakia, Oral - surgery Lip Neoplasms - genetics Lip Neoplasms - pathology Lip Neoplasms - surgery Medicine Medicine & Public Health Mouth Mucosa - pathology Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - surgery Oral and Maxillofacial Surgery Precancerous Conditions - genetics Precancerous Conditions - pathology Precancerous Conditions - surgery Prognosis Review Article Risk Factors Smoking - adverse effects |
| title | Oral field cancerization: current evidence and future perspectives |
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