Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells

CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with the anti-DNA H-chain transgenic mouse lines 3H9 and 56R, well-characterized models for studying B-ce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-05, Vol.109 (20), p.7811-7816
Hauptverfasser:	Kishi, Yusuke, Higuchi, Tetsuya, Phoon, Shirly, Sakamaki, Yasuo, Kamiya, Koki, Riemekasten, Gabriela, Akiyoshi, Kazunari, Weigert, Martin G., Tsubata, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anergy Animals Antibodies Antibodies, Antinuclear Antibodies, Antinuclear - immunology Antibodies, Antinuclear - metabolism Antigens Apoptosis Apoptosis - immunology Autoantibodies Autoantibodies - biosynthesis Autoantibodies - immunology B lymphocytes B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological Sciences biosynthesis Bone marrow CD40 Ligand CD40 Ligand - genetics CD40 Ligand - immunology CD40L protein Cell migration Cells Clodronic Acid Crosses, Genetic Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Gene expression genetics Hybridomas Immune Tolerance Immune Tolerance - immunology Immunoglobulins Immunohistochemistry Immunological tolerance immunology Indoles Liposomes Lupus Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - physiopathology Lymphocytes B metabolism Mice Mice, Transgenic nuclear antigens pathogenesis physiopathology Proteins Receptors Ribonucleoproteins Rodents Spleen Spleen cells Transgenic mice
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