Negative modulation of GABA^sub A^ [alpha]5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats

A growing body of evidence suggests that negative modulation of γ-aminobutyric acid (GABA) GABA^sub A^ α5 receptors may be a promising strategy for the treatment of certain facets of cognitive impairment; however, selective modulators of GABA^sub A^ α5 receptors have not yet been tested in "sch...

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Veröffentlicht in:	Psychopharmacology 2012-06, Vol.221 (3), p.451
Hauptverfasser:	Redrobe, John P, Elster, Lisbeth, Frederiksen, Kristen, Bundgaard, Christoffer, de Jong, Inge E, M, Smith, Garrick P, Bruun, Anne Techau, Larsen, Peter H, Didriksen, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Cognitive ability Psychopharmacology Schizophrenia
Online-Zugang:	Volltext
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