Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci

Chromosomal loci jiggle in place between segregation events in prokaryotic cells and during interphase in eukaryotic nuclei. This motion seems random and is often attributed to Brownian motion. However, we show here that locus dynamics in live bacteria and yeast are sensitive to metabolic activity....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-05, Vol.109 (19), p.7338-7343
Hauptverfasser:	Weber, Stephanie C, Spakowitz, Andrew J, Theriot, Julie A
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol 2,4-Dinitrophenol - pharmacology Adenosine triphosphatase adenosine triphosphate Adenosine Triphosphate - metabolism Algorithms Antimetabolites Antimetabolites - pharmacology Azides bacteria Biological Sciences Brownian motion Cell walls Cells Chromosomes Chromosomes, Bacterial Chromosomes, Bacterial - genetics Chromosomes, Bacterial - metabolism Chromosomes, Fungal Chromosomes, Fungal - genetics Chromosomes, Fungal - metabolism Cytoplasm Deoxyglucose Deoxyglucose - pharmacology Diffusion diffusivity DNA drug effects enzyme activity Enzyme Inhibitors Enzyme Inhibitors - pharmacology Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Gene loci Genetic Loci genetics heat interphase Kinetics loci Metabolism Microscopy, Video Motion Nucleic Acid Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors - pharmacology pharmacology Prokaryotic cells Rifampin Rifampin - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Sodium Sodium Azide Sodium Azide - pharmacology Temperature Time-Lapse Imaging Uncoupling Agents Uncoupling Agents - pharmacology Viscosity Yeasts
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