Oxidative Eustress in Exercise Physiology

This book unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e., it may be possible to maximize the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration, and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Key Features Defines essential redox biology reactions and concepts in exercise physiology Assesses key redox parameters in an in vivo human exercise context Identifies the challenges, opportunities, and boundaries of current knowledge Includes a critique of the underlying mechanisms Summarizes examples of translationally important research relating to disease states