The LEF1/β-Catenin Complex Activates movo1, A Mouse Homolog of Drosophila ovo Required for Epidermal Appendage Differentiation
Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evide...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.6064-6069 |
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| creator | Li, Baoan Mackay, Douglas R. Dai, Qian Tony W. H. Li Nair, Mahalakshmi Fallahi, Magid Schonbaum, Christopher P. Fantes, Judith Mahowald, Anthony P. Waterman, Marian L. Fuchs, Elaine Dai, Xing |
| description | Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evidence that movo1 encodes a nuclear DNA binding protein (mOvo1a) that binds to DNA sequences similar to those that dOvo binds to, further supporting the notion that mOvo1a and dOvo are genetically and biochemically homologous proteins. Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/β-catenin complex, a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during hair morphogenesis in mice, and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies. |
| doi_str_mv | 10.1073/pnas.092137099 |
| format | Article |
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H. Li ; Nair, Mahalakshmi ; Fallahi, Magid ; Schonbaum, Christopher P. ; Fantes, Judith ; Mahowald, Anthony P. ; Waterman, Marian L. ; Fuchs, Elaine ; Dai, Xing</creator><creatorcontrib>Li, Baoan ; Mackay, Douglas R. ; Dai, Qian ; Tony W. H. Li ; Nair, Mahalakshmi ; Fallahi, Magid ; Schonbaum, Christopher P. ; Fantes, Judith ; Mahowald, Anthony P. ; Waterman, Marian L. ; Fuchs, Elaine ; Dai, Xing</creatorcontrib><description>Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evidence that movo1 encodes a nuclear DNA binding protein (mOvo1a) that binds to DNA sequences similar to those that dOvo binds to, further supporting the notion that mOvo1a and dOvo are genetically and biochemically homologous proteins. Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/β-catenin complex, a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during hair morphogenesis in mice, and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.092137099</identifier><identifier>PMID: 11983900</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies ; Appendages ; b-catenin ; Base Sequence ; beta Catenin ; Binding Sites ; Biological Sciences ; Cell Differentiation ; Cell Nucleus - metabolism ; Chromosomes - metabolism ; Cloning, Molecular ; Cytoskeletal Proteins - metabolism ; Deoxyribonuclease I - metabolism ; DNA, Complementary - metabolism ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Epidermal Cells ; Epidermis ; Epidermis - embryology ; Genes ; Hair ; Hair follicles ; Immunoblotting ; Immunohistochemistry ; LEF1 protein ; Lymphoid Enhancer-Binding Factor 1 ; Mice ; Microscopy, Fluorescence ; Molecular Sequence Data ; Morphogenesis ; movo1 gene ; Promoter Regions, Genetic ; Protein Binding ; Proteins ; Recombinant Proteins - metabolism ; Rodents ; Sequence Homology, Amino Acid ; Trans-Activators ; Transcription Factors - metabolism ; Transcription Factors - physiology ; Transfection ; wnt gene ; Zinc</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2002-04, Vol.99 (9), p.6064-6069</ispartof><rights>Copyright 1993-2002 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Apr 30, 2002</rights><rights>Copyright © 2002, The National Academy of Sciences 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/99/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3058625$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3058625$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11983900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Baoan</creatorcontrib><creatorcontrib>Mackay, Douglas R.</creatorcontrib><creatorcontrib>Dai, Qian</creatorcontrib><creatorcontrib>Tony W. H. Li</creatorcontrib><creatorcontrib>Nair, Mahalakshmi</creatorcontrib><creatorcontrib>Fallahi, Magid</creatorcontrib><creatorcontrib>Schonbaum, Christopher P.</creatorcontrib><creatorcontrib>Fantes, Judith</creatorcontrib><creatorcontrib>Mahowald, Anthony P.</creatorcontrib><creatorcontrib>Waterman, Marian L.</creatorcontrib><creatorcontrib>Fuchs, Elaine</creatorcontrib><creatorcontrib>Dai, Xing</creatorcontrib><title>The LEF1/β-Catenin Complex Activates movo1, A Mouse Homolog of Drosophila ovo Required for Epidermal Appendage Differentiation</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evidence that movo1 encodes a nuclear DNA binding protein (mOvo1a) that binds to DNA sequences similar to those that dOvo binds to, further supporting the notion that mOvo1a and dOvo are genetically and biochemically homologous proteins. Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/β-catenin complex, a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during hair morphogenesis in mice, and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Appendages</subject><subject>b-catenin</subject><subject>Base Sequence</subject><subject>beta Catenin</subject><subject>Binding Sites</subject><subject>Biological Sciences</subject><subject>Cell Differentiation</subject><subject>Cell Nucleus - metabolism</subject><subject>Chromosomes - metabolism</subject><subject>Cloning, Molecular</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Deoxyribonuclease I - metabolism</subject><subject>DNA, Complementary - metabolism</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Epidermal Cells</subject><subject>Epidermis</subject><subject>Epidermis - embryology</subject><subject>Genes</subject><subject>Hair</subject><subject>Hair follicles</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>LEF1 protein</subject><subject>Lymphoid Enhancer-Binding Factor 1</subject><subject>Mice</subject><subject>Microscopy, Fluorescence</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis</subject><subject>movo1 gene</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Recombinant Proteins - metabolism</subject><subject>Rodents</subject><subject>Sequence Homology, Amino Acid</subject><subject>Trans-Activators</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - physiology</subject><subject>Transfection</subject><subject>wnt gene</subject><subject>Zinc</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFuEzEQhi0EoqFw5QTI4sCJbcf22msfOERpSpGCkFA5W86uN3HkXW_t3aiceCcehGfCqCEqCInTSPN_M_rntxF6TuCMQMXOh96kM1CUsAqUeoBmBBQpRKngIZoB0KqQJS1P0JOUdgCguITH6IQQJZkCmKFv11uLV8tLcv7je7Ewo-1djxehG7y9xfN6dPvcS7gL-0De4jn-GKZk8VXogg8bHFp8EUMKw9Z5gzODP9ubyUXb4DZEvBxcY2NnPJ4Pg-0bs7H4wrWtjbYfnRld6J-iR63xyT471FP05XJ5vbgqVp_ef1jMV8WOKT4WEsqGSrFuKLB8AhG8bdZEClFXFOracGNLAC4omJo3RFFlKS_pmtPagGSCnaJ3d3uHad3Zps4GovF6iK4z8asOxuk_ld5t9SbsNaFUAc3zbw7zMdxMNo26c6m23pve5kh0RUTOWcF_QSIZpZT_2vj6L3AXptjnEDQFwlQpVZmhV_dtH_3-fsAMvDwA-SMcZaW00gJEec_OP3XdTt6P9nbM4Is7cJfGEI8kAy4F5ewnwwq-cA</recordid><startdate>20020430</startdate><enddate>20020430</enddate><creator>Li, Baoan</creator><creator>Mackay, Douglas R.</creator><creator>Dai, Qian</creator><creator>Tony W. 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Li</creator><creator>Nair, Mahalakshmi</creator><creator>Fallahi, Magid</creator><creator>Schonbaum, Christopher P.</creator><creator>Fantes, Judith</creator><creator>Mahowald, Anthony P.</creator><creator>Waterman, Marian L.</creator><creator>Fuchs, Elaine</creator><creator>Dai, Xing</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20020430</creationdate><title>The LEF1/β-Catenin Complex Activates movo1, A Mouse Homolog of Drosophila ovo Required for Epidermal Appendage Differentiation</title><author>Li, Baoan ; Mackay, Douglas R. ; Dai, Qian ; Tony W. 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H. Li</au><au>Nair, Mahalakshmi</au><au>Fallahi, Magid</au><au>Schonbaum, Christopher P.</au><au>Fantes, Judith</au><au>Mahowald, Anthony P.</au><au>Waterman, Marian L.</au><au>Fuchs, Elaine</au><au>Dai, Xing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The LEF1/β-Catenin Complex Activates movo1, A Mouse Homolog of Drosophila ovo Required for Epidermal Appendage Differentiation</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2002-04-30</date><risdate>2002</risdate><volume>99</volume><issue>9</issue><spage>6064</spage><epage>6069</epage><pages>6064-6069</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Drosophila ovo/svb (dovo) is required for epidermal cuticle/denticle differentiation and is genetically downstream of the wg signaling pathway. Similarly, a mouse homolog of dovo, movo1, is required for the proper formation of hair, a mammalian epidermal appendage. Here, we provide biochemical evidence that movo1 encodes a nuclear DNA binding protein (mOvo1a) that binds to DNA sequences similar to those that dOvo binds to, further supporting the notion that mOvo1a and dOvo are genetically and biochemically homologous proteins. Additionally, we show that the movo1 promoter is activated by the lymphoid enhancer factor 1 (LEF1)/β-catenin complex, a transducer of wnt signaling. Collectively, our findings suggest that movo1 is a developmental target of wnt signaling during hair morphogenesis in mice, and that the wg/wnt-ovo link in epidermal appendage regulatory pathways has been conserved between mice and flies.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>11983900</pmid><doi>10.1073/pnas.092137099</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Antibodies Appendages b-catenin Base Sequence beta Catenin Binding Sites Biological Sciences Cell Differentiation Cell Nucleus - metabolism Chromosomes - metabolism Cloning, Molecular Cytoskeletal Proteins - metabolism Deoxyribonuclease I - metabolism DNA, Complementary - metabolism DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Epidermal Cells Epidermis Epidermis - embryology Genes Hair Hair follicles Immunoblotting Immunohistochemistry LEF1 protein Lymphoid Enhancer-Binding Factor 1 Mice Microscopy, Fluorescence Molecular Sequence Data Morphogenesis movo1 gene Promoter Regions, Genetic Protein Binding Proteins Recombinant Proteins - metabolism Rodents Sequence Homology, Amino Acid Trans-Activators Transcription Factors - metabolism Transcription Factors - physiology Transfection wnt gene Zinc |
| title | The LEF1/β-Catenin Complex Activates movo1, A Mouse Homolog of Drosophila ovo Required for Epidermal Appendage Differentiation |
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