Heterologous Regulation of Trafficking and Signaling of G Protein-Coupled Receptors: β-Arrestin-Dependent Interactions between Neurokinin Receptors

Cells express multiple G protein-coupled receptors that are simultaneously or sequentially activated by agonists. The consequences of activating one receptor on signaling and trafficking of another receptor are unknown. We examined the effects of selective activation of the neurokinin 1 receptor (NK...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (5), p.3324-3329
Hauptverfasser:	Schmidlin, Fabien, Déry, Olivier, Bunnett, Nigel W., Grady, Eileen F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals arrestin Arrestins - genetics Arrestins - metabolism beta-Arrestin 1 beta-Arrestins Biological Sciences Biological Transport Cell Line, Transformed Cell lines Cell membranes Cellular biology Cytosol Endocytosis Endosomes Endosomes - metabolism GTP-Binding Proteins - metabolism Inurement Mice Neurons Neurotransmitters Physiological regulation Proteins Rats Receptors Receptors, Neurokinin-1 - agonists Receptors, Neurokinin-1 - genetics Receptors, Neurokinin-1 - metabolism Receptors, Neurokinin-3 - agonists Receptors, Neurokinin-3 - genetics Receptors, Neurokinin-3 - metabolism Signal Transduction
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